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The map label for this gene is waaD [H]

Identifier: 57238026

GI number: 57238026

Start: 1204539

End: 1205492

Strand: Reverse

Name: waaD [H]

Synonym: CJE1287

Alternate gene names: 57238026

Gene position: 1205492-1204539 (Counterclockwise)

Preceding gene: 57238027

Following gene: 57238025

Centisome position: 67.81

GC content: 30.29

Gene sequence:

>954_bases
ATGAGAGTAGCAATCACAGGTGGTGCAGGATTTATAGGTTCGCAACTGGCTTTAAATTTGCAAGAAAAACATGAAATTTT
AATCATTGATAAAATGCGTAGCAGTGCGACTTTTGAAAATGGAAATTTACAAAGTTTTGGACATTTTAAAAATTTACTTG
AATTTGATGGAGAACTTTTTGCAGGTGATATTAACGATGAAAAAGTTTTAAAAAAGATTGAAGATTTTAAGCCAGAGATT
ATTTTTCATCAAGCAGCAATTTCAGACACTACAGTTTTTGATCAAACTAAGGTTTTACAAACCAATTTAAATACTTTTAA
AGATTTTATAGAACTTAGCATAGATCTTAATGCAAAGCTTATTTATGCAAGTTCAGCTTCGGTTTATGGTGATGCAAAAA
GTCCACAAACTGTAGGTAAAGATGAAGAGCCAAAAAATCCTTATGCTTTTTCAAAATTGATGATGGATAAGTTAGCGAAA
AAATATTACGATAAAGCTCATTTGGTAGGACTTAGATATTTTAATGTTTATGGAAAAGGCGAATTTTATAAAAACAAAAC
CGCTTCTATGGTTTTGCAATTTGGCCATCAAATTTTAGCAGGAAAAAATCCACGATTGTTTGAAGGAAGTGATCAAATTT
ATAGAGATTTTACTTATATTAAAGATGTTATTAATGCCAATTTAATCGCCCTTGATTCAAAATGCGGGGTTTATAATGTA
GGCAGTGGTAAAGCAAGAACCTTTCAAGATATAGTTGATATTTTGCAAAAAGAGTTAAAGACTGATTTGCCTTGTGAATA
TATCCCAAATCCTTATGTAAAATCTTATCAATTCCATACTGAAGCAAAACTAGATCAAACTTGGGATTATCAGCCAAAAT
TTAGTCTTGAAGAGGGGATTAAAGATTATTTAGATGAGATAAAAAGACTTTTTGAAAAGGAAGTAAATGCTTGA

Upstream 100 bases:

>100_bases
TTTGGTTTTAGTAAATGAAGAAAAAAAAGAAGGCGATTTTTTTAGACAATTTAAAAATTTAAAAGAAATTTTGAGTTTTT
TTAAAGAAAAGGACATTTAA

Downstream 100 bases:

>100_bases
GTTTTTAAGCCAGCAAAAACCTAAAATTTTAATTATAGGGGATTTTATGGTGGATAATTACACTTGGTGTGATTGTTCGC
GTATCAGTCCTGAAGCCCCT

Product: ADP-L-glycero-D-mannoheptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MRVAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVGKDEEPKNPYAFSKLMMDKLAK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPRLFEGSDQIYRDFTYIKDVINANLIALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLDEIKRLFEKEVNA

Sequences:

>Translated_317_residues
MRVAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVGKDEEPKNPYAFSKLMMDKLAK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPRLFEGSDQIYRDFTYIKDVINANLIALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLDEIKRLFEKEVNA
>Mature_317_residues
MRVAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVGKDEEPKNPYAFSKLMMDKLAK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPRLFEGSDQIYRDFTYIKDVINANLIALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLDEIKRLFEKEVNA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=341, Percent_Identity=25.2199413489736, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790049, Length=319, Percent_Identity=32.6018808777429, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786974, Length=331, Percent_Identity=25.0755287009063, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=334, Percent_Identity=26.3473053892216, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=336, Percent_Identity=26.7857142857143, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=297, Percent_Identity=26.5993265993266, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19923002, Length=290, Percent_Identity=26.2068965517241, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356223, Length=268, Percent_Identity=25.7462686567164, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36137; Mature: 36137

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELF
CEEEEECCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AGDINDEKVLKKIEDFKPEIIFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKL
ECCCCHHHHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEE
IYASSASVYGDAKSPQTVGKDEEPKNPYAFSKLMMDKLAKKYYDKAHLVGLRYFNVYGKG
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEEEEEEECCC
EFYKNKTASMVLQFGHQILAGKNPRLFEGSDQIYRDFTYIKDVINANLIALDSKCGVYNV
CHHCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEC
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCCCCCCCCCCCCCCCHHHHH
KDYLDEIKRLFEKEVNA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELF
CEEEEECCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AGDINDEKVLKKIEDFKPEIIFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKL
ECCCCHHHHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEE
IYASSASVYGDAKSPQTVGKDEEPKNPYAFSKLMMDKLAKKYYDKAHLVGLRYFNVYGKG
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEEEEEEECCC
EFYKNKTASMVLQFGHQILAGKNPRLFEGSDQIYRDFTYIKDVINANLIALDSKCGVYNV
CHHCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEC
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCCCCCCCCCCCCCCCHHHHH
KDYLDEIKRLFEKEVNA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA