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The map label for this gene is hemD

Identifier: 57237962

GI number: 57237962

Start: 1138494

End: 1139123

Strand: Reverse

Name: hemD

Synonym: CJE1223

Alternate gene names: NA

Gene position: 1139123-1138494 (Counterclockwise)

Preceding gene: 57237963

Following gene: 57237956

Centisome position: 64.07

GC content: 26.98

Gene sequence:

>630_bases
ATGAAAATTTATCTCTTAAATGAAACTCCTTTTGAAGGGGTGGAAAATCTTATTTTAAATGAGATTGTTTTTTATGATTT
TAGTGTGGATTTGAGTTTGTATGATGCTTTAATCTGCACTTCAAAAAATGCTTTAAAAGCTTTACAACATGCAAAAATCA
CTTTAAATTTCAAACTCAATTTATACGCTGTGGGACAAAGTACAGCTCAATACGCTAAAAATTTAGGTTTTAAAAAGATT
AAAATTCCATCAAAGGCTTATGGAAAAGATCTTTTTCTTGAATTTAAAGAGGAGTTAAAAATGCAAAAATGTTTGTATTT
AAGGGCTAAAAATATTGTTTCAACTTTAAATTTGGATCTTAAAAATGTAGGTGTGGATTTAGATGAAATGATTGTTTATG
AAAATGTTTTTAAAAAAGGCGACAAAAAGCTTATCTATCCTGCTATTTTTATATTCACCTCTCCTTTAAGTGTAGAAAAT
TTTTTAAAATTTTATAGCTTAAAAGAAGAAGATAAGGTTGTAGTTATAGGGCAAAGCACAGCAAAGAAGCTTTTAAATTT
TAAAAATCTTTATATATGCGAAAATCAAAGTCTTTTAGACTGTGTTAAGCTCGCTAAGACTTTGGTTTAA

Upstream 100 bases:

>100_bases
GAGTTAAAGGGTATAAATTTAAGCGGTGTGGCTGTGGTTAGGGCGATCATGGATGCTAAAGATGCTTTTTTGGCAGCTAA
AGAGCTAAAGCGTAAAATCT

Downstream 100 bases:

>100_bases
TTTTTTAAATTCCAAAAATTTTCTTTGGGATAAATAATAATGCTTTTTGTGAGTAAAATTTCATCATTGACGTTTTTATC
ACGATTTAAAGCAATACTAA

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase HemD; Uroporphyrinogen III Cosynthase HemD; Uroporphyrinogen-III Synthetase; Uroporphyrinogen III Cosynthase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLNLYAVGQSTAQYAKNLGFKKI
KIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDLKNVGVDLDEMIVYENVFKKGDKKLIYPAIFIFTSPLSVEN
FLKFYSLKEEDKVVVIGQSTAKKLLNFKNLYICENQSLLDCVKLAKTLV

Sequences:

>Translated_209_residues
MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLNLYAVGQSTAQYAKNLGFKKI
KIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDLKNVGVDLDEMIVYENVFKKGDKKLIYPAIFIFTSPLSVEN
FLKFYSLKEEDKVVVIGQSTAKKLLNFKNLYICENQSLLDCVKLAKTLV
>Mature_209_residues
MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLNLYAVGQSTAQYAKNLGFKKI
KIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDLKNVGVDLDEMIVYENVFKKGDKKLIYPAIFIFTSPLSVEN
FLKFYSLKEEDKVVVIGQSTAKKLLNFKNLYICENQSLLDCVKLAKTLV

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 23938; Mature: 23938

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLN
CEEEEECCCCHHHHHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHHHHCEEEEEEEEE
LYAVGQSTAQYAKNLGFKKIKIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDL
EEEECCHHHHHHHCCCCEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KNVGVDLDEMIVYENVFKKGDKKLIYPAIFIFTSPLSVENFLKFYSLKEEDKVVVIGQST
HHCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECHH
AKKLLNFKNLYICENQSLLDCVKLAKTLV
HHHHHCCCCEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKIYLLNETPFEGVENLILNEIVFYDFSVDLSLYDALICTSKNALKALQHAKITLNFKLN
CEEEEECCCCHHHHHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHHHHCEEEEEEEEE
LYAVGQSTAQYAKNLGFKKIKIPSKAYGKDLFLEFKEELKMQKCLYLRAKNIVSTLNLDL
EEEECCHHHHHHHCCCCEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KNVGVDLDEMIVYENVFKKGDKKLIYPAIFIFTSPLSVENFLKFYSLKEEDKVVVIGQST
HHCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECHH
AKKLLNFKNLYICENQSLLDCVKLAKTLV
HHHHHCCCCEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA