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The map label for this gene is guaB [H]

Identifier: 57237943

GI number: 57237943

Start: 1120198

End: 1121655

Strand: Reverse

Name: guaB [H]

Synonym: CJE1201

Alternate gene names: 57237943

Gene position: 1121655-1120198 (Counterclockwise)

Preceding gene: 57237944

Following gene: 57237942

Centisome position: 63.09

GC content: 38.68

Gene sequence:

>1458_bases
ATGAAAATTGTAAAAAGAGCTTTAACTTTTGAAGATGTATTATTGCGTCCTGGGTATTCTGAAGTTCTACCTAAGGAAGT
AAAAATTCATACTAAACTGACAAAAAATATCACTTTAAATATGCCTTTAATCTCTGCGGCTATGGATACAGTTACTGAAC
ACAGGGCTGCTATTATGATGGCAAGACTTGGAGGGCTTGGAGTGATTCATAAAAACATGGATATAACCTCACAGGTTAGA
GAAGTAAAAAGAGTGAAAAAAAGCGAAAGCGGGGTGATTATCGATCCTATTTTTGTAAGTCCTAAGGCAAGTGTTGCGGA
AGCTTTAGAAATTATGGCAGAGTATAGAATTTCAGGTGTTCCTGTAGTAGATGAAGATAAGAAACTAATAGGCATACTCA
CCAATCGTGATTTAAGATTTGAGAGTGATTTTTCAAATTTGGTTGAAAATGTTATGACTAAAATGCCTTTAATCACTGCT
CCAAAGGGTTGTACTTTAGATGATGCGGAAAAAATTTTCAGTACCAACAAAGTAGAAAAACTTCCTATAGTGGATGAACA
AGGACGCTTGGAAGGACTTATCACTATAAAAGATCTTAAAAAACGCAAAGAATATCCTGATGCCAATAAAGATAATTTTG
GAAGATTACGTGTGGGTGCGGCTATAGGAGTAGGACAAATGGATCGTGTGGATGCTTTAGTTGAAGCGGGCGTTGATGTT
GTTGTGCTTGATTCTGCGCATGGACATTCTAAGGGTATTATTGATACAGTAAAAGCGATTAAAGCTAAATATCCAAATTT
AGATCTTATCGCAGGAAATATCGCCACTGCAGCTGCAGCAAAAGCACTTTGTGAAGCAGGAGTAGATGCGGTTAAAGTAG
GTATTGGGCCAGGAAGTATTTGTACCACACGTATTGTTTCAGGTGTGGGTGTGCCTCAAATTTCGGCCATTGATGAGTGC
GTGGAAGAAGCAAATAAATTTGGCATTCCTGTGATAGCTGATGGCGGGATTAAATATTCAGGTGATATTGCAAAAGCTTT
AGCCGTAGGTGCGAGTTCTGTTATGATAGGATCGCTTTTAGCTGGAACAGATGAGAGTCCAGGAGAGCTTTTTACTTATC
AAGGAAGACAATATAAGTCTTATCGTGGTATGGGCTCGCTTGGGGCTATGCAAAAGGGAAGTTCGGATAGATATTTTCAG
CAAGGTACCGCTCAAGATAAACTCGTTCCTGAAGGTATAGAAGGGCGTGTTCCTTATGTGGGAAGTATAAGAAGTGTGGT
TCACCAACTTTTAGGAGGTTTGCGTTCTTCTATGGGTTATGTTGGGGCTAAAGATATAGAAGATTTTCAAAAAAGAGCCG
AATTTGTTGAAATTACCACTGCAGGACTTAAAGAAAGTCACGTGCATGATGTTACTATCACTCATGAAGCACCAAACTAC
AAGGTTAATCATCAATGA

Upstream 100 bases:

>100_bases
TAATATATCAGCACAACTGATTTGCAAAGCTTATGATGAACAAACCTTGTTAGACGGGGCTTTAAGTTTAGAACAAATGA
TTAAAAATTAAGGATGAAAG

Downstream 100 bases:

>100_bases
GTTTTGAAGAAAATTTAAAACACGCTAATGAATCTTTGGAAAAATTAAATAATCAAGAGCTTGCCTTAGATGAAAGTGTA
AAAATTTATAAAGAAGGTTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDITSQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
VVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGVGVPQISAIDEC
VEEANKFGIPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ

Sequences:

>Translated_485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDITSQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
VVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGVGVPQISAIDEC
VEEANKFGIPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ
>Mature_485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDITSQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
VVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGVGVPQISAIDEC
VEEANKFGIPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=45.8333333333333, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI217035146, Length=450, Percent_Identity=46, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI34328930, Length=450, Percent_Identity=46, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=450, Percent_Identity=46, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=450, Percent_Identity=46, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI217035152, Length=457, Percent_Identity=45.5142231947484, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI217035148, Length=450, Percent_Identity=45.3333333333333, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI217035150, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI50541956, Length=371, Percent_Identity=31.8059299191375, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI50541954, Length=263, Percent_Identity=36.5019011406844, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI50541952, Length=263, Percent_Identity=36.5019011406844, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI50541948, Length=263, Percent_Identity=36.5019011406844, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI156104880, Length=376, Percent_Identity=31.9148936170213, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=57.5257731958763, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.6515837104072, Blast_Score=158, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=36, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.5342789598109, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=273, Percent_Identity=35.1648351648352, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=42.0618556701031, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=44.0748440748441, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=42.2037422037422, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=42.8152492668622, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=129, Percent_Identity=41.0852713178295, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=42.7974947807933, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=42.7974947807933, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=42.8246013667426, Blast_Score=311, Evalue=9e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52196; Mature: 52196

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMM
CCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHH
ARLGGLGVIHKNMDITSQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGV
HHHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCC
PVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITAPKGCTLDDAEKIFSTNKVEK
CEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCC
LPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCE
VVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSI
EEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHH
CTTRIVSGVGVPQISAIDECVEEANKFGIPVIADGGIKYSGDIAKALAVGASSVMIGSLL
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHH
AGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQDKLVPEGIEGRVPYV
CCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
GSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCE
KVNHQ
ECCCC
>Mature Secondary Structure
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMM
CCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHH
ARLGGLGVIHKNMDITSQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGV
HHHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCC
PVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITAPKGCTLDDAEKIFSTNKVEK
CEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCC
LPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCE
VVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSI
EEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHH
CTTRIVSGVGVPQISAIDECVEEANKFGIPVIADGGIKYSGDIAKALAVGASSVMIGSLL
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHH
AGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQDKLVPEGIEGRVPYV
CCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
GSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCE
KVNHQ
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]