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The map label for this gene is murC [H]

Identifier: 57237940

GI number: 57237940

Start: 1117834

End: 1119129

Strand: Reverse

Name: murC [H]

Synonym: CJE1198

Alternate gene names: 57237940

Gene position: 1119129-1117834 (Counterclockwise)

Preceding gene: 57237941

Following gene: 57237939

Centisome position: 62.95

GC content: 33.95

Gene sequence:

>1296_bases
ATGCAAAATATCCATTTTATCGGCATAGGCGGTATAGGAATTTCCGCTTTAGCAAGATTTTTAAAAGAAAAAGGTTTTAA
AATTAGCGGAAGTGATCTTAAAGAGAGTAAAATCACTAAAGAACTAGAAAAAGAAGGGGTTAAGGTCAGTATCCCTCATC
ATAAAGACAATATTTTAAACAAAGATTTAGTTATTTATTCTGCTGCTATCAAAGAAGAAAATCCTGAATTTAAACACGCT
AAAGAATTAGGCATTAAATGCCTTTCACGCAAGGAGGCCTTACCTCTTATCTTAGAAGATAAGCGCGTTTTTGCAGTTGC
AGGAGCACATGGAAAAAGCACAACTTCAAGTATTTTGGCTTCTTTGCTTGATGATGCTTCTGTGATCATCGGAGCGATTT
TAAAAGAATTTGGTTCAAATATGATTTATAAAGAAAGCCAAAACCTTGTTTTTGAAGCTGATGAGAGCGATAGTTCTTTT
TTAAATTCAAATCCTTATTTGGCTATAGTTACTAATGCAGAAGCAGAGCATTTAGATCATTATGGTAATGAAGTTTCAAA
ACTCCATCATGCTTATGCGGAGTTTTTAGATACGGCTAAAATTCGCGTGATTAATGCTGAAGATGAGTTTTTGAAAAATT
ATAAAAATGAGTCAACCAAGCTTTATCCGAGCAAAGATATCAAAAACTGCACCATGCGTATAGAAAATTTCAAACCTTTT
ACAAGCTTTGAGTTGAAAGATTTAGGTGAATTTAAGGTTTTTGGCATGGGATATCATTTAGCCCTTGATGCGTCTTTGGC
GATTTTGGCGGCTTTAAATTTCTTAGATATAGAAACGATAAGAACTAGGCTTAAAAATTATCAAGGTATTAAAAAGCGTT
TTGATATTTTATATGCTGATGAAAATTTGGTTTTAATCGATGATTATGGTCATCATCCTACCGAAATAAAAGCGACTTTA
AGCGCAGCACAAGAATACGCAAAATTAGGCGGATATAAAAAAATTACAGCCATTTTTGAACCCCACCGCTACACGCGTTT
GGCTGCAAATTTAAAGGAATTTGCAAAGGCTTTTGAGAGTATTGATGAGCTTGTAATTTTACCTGTTTATGCTGCAGGAG
AAGAGCCTATAGAACTTGATTTAAAAGCGGTTTTTCCTAAGGCTTTATTTGTAGAAGATATCAAAAGAGAGGGTAGATTT
TTAGTAGCTTCTAAGGGGCAAGTTTTTGAAGAAGGGCTTATTATAGGTTTTGGTGCAGGAGATATTAGTAATAAATTAAG
GCAAAAAGATGAGTAG

Upstream 100 bases:

>100_bases
TTTATAAAAGTTATCTAGAGCTGATAGAAGCTAAGGTTTATATTTTCTTTTTAGTAAAAAAGTGCTAAAATTTAGCCTTT
AAGGTATAAAGGTTTAAATG

Downstream 100 bases:

>100_bases
GTTTTTTTTATATTTTTTAATTATTTTAATTTTAGCCTTAATCACTTTTGCTTTGCGTGAAAAATTAGGCAAAAAAACTA
AACCTTTTTTTGGTATTTTA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILNKDLVIYSAAIKEENPEFKHA
KELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILASLLDDASVIIGAILKEFGSNMIYKESQNLVFEADESDSSF
LNSNPYLAIVTNAEAEHLDHYGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESTKLYPSKDIKNCTMRIENFKPF
TSFELKDLGEFKVFGMGYHLALDASLAILAALNFLDIETIRTRLKNYQGIKKRFDILYADENLVLIDDYGHHPTEIKATL
SAAQEYAKLGGYKKITAIFEPHRYTRLAANLKEFAKAFESIDELVILPVYAAGEEPIELDLKAVFPKALFVEDIKREGRF
LVASKGQVFEEGLIIGFGAGDISNKLRQKDE

Sequences:

>Translated_431_residues
MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILNKDLVIYSAAIKEENPEFKHA
KELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILASLLDDASVIIGAILKEFGSNMIYKESQNLVFEADESDSSF
LNSNPYLAIVTNAEAEHLDHYGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESTKLYPSKDIKNCTMRIENFKPF
TSFELKDLGEFKVFGMGYHLALDASLAILAALNFLDIETIRTRLKNYQGIKKRFDILYADENLVLIDDYGHHPTEIKATL
SAAQEYAKLGGYKKITAIFEPHRYTRLAANLKEFAKAFESIDELVILPVYAAGEEPIELDLKAVFPKALFVEDIKREGRF
LVASKGQVFEEGLIIGFGAGDISNKLRQKDE
>Mature_431_residues
MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILNKDLVIYSAAIKEENPEFKHA
KELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILASLLDDASVIIGAILKEFGSNMIYKESQNLVFEADESDSSF
LNSNPYLAIVTNAEAEHLDHYGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESTKLYPSKDIKNCTMRIENFKPF
TSFELKDLGEFKVFGMGYHLALDASLAILAALNFLDIETIRTRLKNYQGIKKRFDILYADENLVLIDDYGHHPTEIKATL
SAAQEYAKLGGYKKITAIFEPHRYTRLAANLKEFAKAFESIDELVILPVYAAGEEPIELDLKAVFPKALFVEDIKREGRF
LVASKGQVFEEGLIIGFGAGDISNKLRQKDE

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=407, Percent_Identity=33.6609336609337, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790680, Length=392, Percent_Identity=25.765306122449, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 48242; Mature: 48242

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00936 RIBOSOMAL_L35

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILN
CCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCC
KDLVIYSAAIKEENPEFKHAKELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILA
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEEEECCCCCCHHHHHHH
SLLDDASVIIGAILKEFGSNMIYKESQNLVFEADESDSSFLNSNPYLAIVTNAEAEHLDH
HHHCCHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHH
YGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESTKLYPSKDIKNCTMRIENFKPF
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCEECCCCCCCHHHEEECCCCCC
TSFELKDLGEFKVFGMGYHLALDASLAILAALNFLDIETIRTRLKNYQGIKKRFDILYAD
CCCCCCCCCCEEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ENLVLIDDYGHHPTEIKATLSAAQEYAKLGGYKKITAIFEPHRYTRLAANLKEFAKAFES
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
IDELVILPVYAAGEEPIELDLKAVFPKALFVEDIKREGRFLVASKGQVFEEGLIIGFGAG
HCCEEEEEEEECCCCCEEEEHHHHCCHHHHHHHHHHCCCEEEEECCCEECCCEEEEECCC
DISNKLRQKDE
HHHHHHHCCCC
>Mature Secondary Structure
MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILN
CCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCC
KDLVIYSAAIKEENPEFKHAKELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILA
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEEEECCCCCCHHHHHHH
SLLDDASVIIGAILKEFGSNMIYKESQNLVFEADESDSSFLNSNPYLAIVTNAEAEHLDH
HHHCCHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHH
YGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESTKLYPSKDIKNCTMRIENFKPF
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCEECCCCCCCHHHEEECCCCCC
TSFELKDLGEFKVFGMGYHLALDASLAILAALNFLDIETIRTRLKNYQGIKKRFDILYAD
CCCCCCCCCCEEEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ENLVLIDDYGHHPTEIKATLSAAQEYAKLGGYKKITAIFEPHRYTRLAANLKEFAKAFES
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
IDELVILPVYAAGEEPIELDLKAVFPKALFVEDIKREGRFLVASKGQVFEEGLIIGFGAG
HCCEEEEEEEECCCCCEEEEHHHHCCHHHHHHHHHHCCCEEEEECCCEECCCEEEEECCC
DISNKLRQKDE
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]