Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 57237624

GI number: 57237624

Start: 809863

End: 810390

Strand: Direct

Name: tpx [H]

Synonym: CJE0870

Alternate gene names: 57237624

Gene position: 809863-810390 (Clockwise)

Preceding gene: 57237623

Following gene: 57237625

Centisome position: 45.55

GC content: 35.8

Gene sequence:

>528_bases
ATGAGTACAGTAAATTTTAAAGGAAATCCTGTAAAACTTAAAGGAAATTCAGTAGAAGTTGGAGCAGATGCTCCTAAGGT
AAATCTTAAAGCTAAAGATTTAAGCGTGATTGAAATCGGTGCAGCGGGTAAAACTCAAATCATTTTAAGTGTTCCAAGCT
TAGATACACCAGTTTGTGCTACAGAGGCTAGAGAATTTAATAAAAAAGTAGCCAGTTACAATGGTGCTGAAGTGATTGTA
GTAAGTATGGACTTACCTTTTGCTATGGGAAGATTTTGCAGTACAGAAGGTATTGAAAATTTAAGTGTTGCAAGTGATTT
TGTGGCAAAAGAATTTGGTGAAAAATATGGTGTTTTGATAAATGAAGGTGCTTTAGAAGGGCTTTTAGCTCGTGCCGTAT
TTGTGATTAAAGAGGGTAAAGTGGCATATAAAGAACTTGTAAATGAAATCACAGAAATGCCAGATATTGCAAAACTTGAT
GCATTTTTTGGTGGTTCTAGCTGCTGCGGTGGTTGTGGTTGCCATTAA

Upstream 100 bases:

>100_bases
AATTTTGAGTGAAATTAAAAAATAATTAATATTTATAGGATATAATCACTCCTAAAACATTAATTGCAATAATGTTTAAA
ATATCAAAAAAGGAAATTAA

Downstream 100 bases:

>100_bases
TTTTTGATTAAGCCCATTCTTAGGGCTTAATTTTTATATCTTCATTTTTTATTATTTTAAGTTGATTATATTTTAATTGT
TAAGTTGATTATTTTTAATA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSTVNFKGNPVKLKGNSVEVGADAPKVNLKAKDLSVIEIGAAGKTQIILSVPSLDTPVCATEAREFNKKVASYNGAEVIV
VSMDLPFAMGRFCSTEGIENLSVASDFVAKEFGEKYGVLINEGALEGLLARAVFVIKEGKVAYKELVNEITEMPDIAKLD
AFFGGSSCCGGCGCH

Sequences:

>Translated_175_residues
MSTVNFKGNPVKLKGNSVEVGADAPKVNLKAKDLSVIEIGAAGKTQIILSVPSLDTPVCATEAREFNKKVASYNGAEVIV
VSMDLPFAMGRFCSTEGIENLSVASDFVAKEFGEKYGVLINEGALEGLLARAVFVIKEGKVAYKELVNEITEMPDIAKLD
AFFGGSSCCGGCGCH
>Mature_174_residues
STVNFKGNPVKLKGNSVEVGADAPKVNLKAKDLSVIEIGAAGKTQIILSVPSLDTPVCATEAREFNKKVASYNGAEVIVV
SMDLPFAMGRFCSTEGIENLSVASDFVAKEFGEKYGVLINEGALEGLLARAVFVIKEGKVAYKELVNEITEMPDIAKLDA
FFGGSSCCGGCGCH

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=156, Percent_Identity=44.2307692307692, Blast_Score=126, Evalue=1e-30,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18428; Mature: 18297

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVNFKGNPVKLKGNSVEVGADAPKVNLKAKDLSVIEIGAAGKTQIILSVPSLDTPVCA
CCCCCCCCCEEEEECCEEEECCCCCEEEEEECCEEEEEECCCCCEEEEEECCCCCCCHHH
TEAREFNKKVASYNGAEVIVVSMDLPFAMGRFCSTEGIENLSVASDFVAKEFGEKYGVLI
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHCHHCCEEE
NEGALEGLLARAVFVIKEGKVAYKELVNEITEMPDIAKLDAFFGGSSCCGGCGCH
ECHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
STVNFKGNPVKLKGNSVEVGADAPKVNLKAKDLSVIEIGAAGKTQIILSVPSLDTPVCA
CCCCCCCCEEEEECCEEEECCCCCEEEEEECCEEEEEECCCCCEEEEEECCCCCCCHHH
TEAREFNKKVASYNGAEVIVVSMDLPFAMGRFCSTEGIENLSVASDFVAKEFGEKYGVLI
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHCHHCCEEE
NEGALEGLLARAVFVIKEGKVAYKELVNEITEMPDIAKLDAFFGGSSCCGGCGCH
ECHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]