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The map label for this gene is fdh [H]

Identifier: 21226851

GI number: 21226851

Start: 897990

End: 899330

Strand: Reverse

Name: fdh [H]

Synonym: MM_0749

Alternate gene names: 21226851

Gene position: 899330-897990 (Counterclockwise)

Preceding gene: 21226854

Following gene: 21226850

Centisome position: 21.95

GC content: 47.95

Gene sequence:

>1341_bases
ATGAAAGCCGTTGTTTATAGGGGACCGAATCAGGTTTCTGTAGAAGAAGTCGAAGATCCGAAAATAGAGCACCCGGCAGA
TGCCATAATCAGGCTTACTTCGAGTGGCATATGCGGAAGCGACCTTCATATGTATGAAGGAAGAACTGTTGAAAAGCCGG
GAAAAGTTCTTGGGCATGAGCCTCTAGGGGTTATAGAAGAGGTGGGGGATGCCGTGACCTCTTTTAAGAAAGGGGACAGG
GTTGTCGTTACTTTTAACATTGCCTGCGGGCACTGTTTGAACTGTATTCGGGGTTTTACCAGCGCCTGCCTGACTGTTAA
TCCCGAAAGTGCAGGAGGAGCTTTTGGATATGCCAAAATGGGTCCTTATAGAGGGGCTCAGGCTGAATTTTTAAGGGTGC
CGTTTGCCGACCTGAACTGTACGAAACTTCCAGGGTCTCCAGGGGATAAATGGGAAGACGATTTCATTATGCTGTCGGAT
GTATTTCCTACAGGTTTTTTTGCTACGCAGCTTGCAATGGTAATGCCAGGATTTCCTGTCGCGGTTTTCGGGGCAGGACC
TGTAGGTTTGCTCTCAGCTTATTCCGCAATATTGCAGGGGGCAGCTCAGGTTTTTGTCGTTGATTACATTCCTGAGAGGC
TGAAGCTGGCAAAGAGTATTGGTGCTATTCCTGTAGATTTTACACTTAGCGACCCCGTAGCCATGATTGAGGCATTAAGG
TCTCAGCATTCGAGAGTGGATACCGTGCTTCCGGGCGAGGAAAAACTGCAGGGAATCATGTCCAGTATAGAAAACCTTGC
CAAGAGTATAGGTGCTAACCTTGAACTCGCCAGGAGCGATCCCGTAACTATGATTCAGATGTTGAGGGCAGGAAACCCTG
CAATTGTTCAGTCCCTGATTCCAGGTGAGGAAAAAATGAAAGGTGTGATGTCCGGTATAGACGCAGTCGGATATCAGGCA
AGAGACAGGCAAGATCCCTCAAGGGAAAACCCAACGCAGGTGATAAGTGATCTGGTGAGGCTTATCAACCCGACCGGTCA
CCTGGGAGTTATCGGGGTCTACGTGGCAGATGACCCCGGAGCTTATAATGAACGCGCTAAGAAAGGGGAGTATATCCTGC
CTTTTGGACAGCTCTGGGAAAAAGGTATAAGTGTAGGAACAGGCCAGACTCCGGTTAAGAAACTTCAACCGATGCTCAGG
GATATGATAATTGCAGGCGTGGCAAAGCCAAGCTTTATAGTAAGTCACAAAATCTCCATAGAGGAAGCGCCTGATGCCTA
CAGGGAGTTTGCCAAACGCTCAGAAGGCTTTACAAAGGTAACAATTCAGTTTGAAAAATAA

Upstream 100 bases:

>100_bases
ATAAAAATACTTTCTATTATCTGGTTATTCTCTGTTTCTCTGCATATGCAGGGAAGGCAAAAAAGCTGGCAGAGAAACTT
CACAGGATTGGGGTGATTTT

Downstream 100 bases:

>100_bases
ATTTTTAAATTTCTTTTTTCAAATTTCTTTTTTCAAATTTATCCTTTCAAATTTAATTTTTTAAATCTAATTTTTTAAAT
TTACCTTTTCAAATTTTTTT

Product: glutathione-independent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKAVVYRGPNQVSVEEVEDPKIEHPADAIIRLTSSGICGSDLHMYEGRTVEKPGKVLGHEPLGVIEEVGDAVTSFKKGDR
VVVTFNIACGHCLNCIRGFTSACLTVNPESAGGAFGYAKMGPYRGAQAEFLRVPFADLNCTKLPGSPGDKWEDDFIMLSD
VFPTGFFATQLAMVMPGFPVAVFGAGPVGLLSAYSAILQGAAQVFVVDYIPERLKLAKSIGAIPVDFTLSDPVAMIEALR
SQHSRVDTVLPGEEKLQGIMSSIENLAKSIGANLELARSDPVTMIQMLRAGNPAIVQSLIPGEEKMKGVMSGIDAVGYQA
RDRQDPSRENPTQVISDLVRLINPTGHLGVIGVYVADDPGAYNERAKKGEYILPFGQLWEKGISVGTGQTPVKKLQPMLR
DMIIAGVAKPSFIVSHKISIEEAPDAYREFAKRSEGFTKVTIQFEK

Sequences:

>Translated_446_residues
MKAVVYRGPNQVSVEEVEDPKIEHPADAIIRLTSSGICGSDLHMYEGRTVEKPGKVLGHEPLGVIEEVGDAVTSFKKGDR
VVVTFNIACGHCLNCIRGFTSACLTVNPESAGGAFGYAKMGPYRGAQAEFLRVPFADLNCTKLPGSPGDKWEDDFIMLSD
VFPTGFFATQLAMVMPGFPVAVFGAGPVGLLSAYSAILQGAAQVFVVDYIPERLKLAKSIGAIPVDFTLSDPVAMIEALR
SQHSRVDTVLPGEEKLQGIMSSIENLAKSIGANLELARSDPVTMIQMLRAGNPAIVQSLIPGEEKMKGVMSGIDAVGYQA
RDRQDPSRENPTQVISDLVRLINPTGHLGVIGVYVADDPGAYNERAKKGEYILPFGQLWEKGISVGTGQTPVKKLQPMLR
DMIIAGVAKPSFIVSHKISIEEAPDAYREFAKRSEGFTKVTIQFEK
>Mature_446_residues
MKAVVYRGPNQVSVEEVEDPKIEHPADAIIRLTSSGICGSDLHMYEGRTVEKPGKVLGHEPLGVIEEVGDAVTSFKKGDR
VVVTFNIACGHCLNCIRGFTSACLTVNPESAGGAFGYAKMGPYRGAQAEFLRVPFADLNCTKLPGSPGDKWEDDFIMLSD
VFPTGFFATQLAMVMPGFPVAVFGAGPVGLLSAYSAILQGAAQVFVVDYIPERLKLAKSIGAIPVDFTLSDPVAMIEALR
SQHSRVDTVLPGEEKLQGIMSSIENLAKSIGANLELARSDPVTMIQMLRAGNPAIVQSLIPGEEKMKGVMSGIDAVGYQA
RDRQDPSRENPTQVISDLVRLINPTGHLGVIGVYVADDPGAYNERAKKGEYILPFGQLWEKGISVGTGQTPVKKLQPMLR
DMIIAGVAKPSFIVSHKISIEEAPDAYREFAKRSEGFTKVTIQFEK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=235, Percent_Identity=31.4893617021277, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501929, Length=232, Percent_Identity=31.4655172413793, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI156627571, Length=236, Percent_Identity=31.3559322033898, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=236, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI71565154, Length=243, Percent_Identity=29.2181069958848, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786825, Length=265, Percent_Identity=41.8867924528302, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1790045, Length=215, Percent_Identity=33.4883720930233, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787863, Length=227, Percent_Identity=32.5991189427313, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=234, Percent_Identity=33.7606837606838, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788073, Length=204, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=31.6964285714286, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081918, Length=223, Percent_Identity=34.0807174887892, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=28.6245353159851, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=199, Percent_Identity=27.6381909547739, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788075, Length=213, Percent_Identity=28.6384976525822, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=226, Percent_Identity=32.7433628318584, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=246, Percent_Identity=31.3008130081301, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=224, Percent_Identity=33.9285714285714, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=224, Percent_Identity=33.9285714285714, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=232, Percent_Identity=31.4655172413793, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=243, Percent_Identity=30.8641975308642, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=269, Percent_Identity=26.7657992565056, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=241, Percent_Identity=26.1410788381743, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737897, Length=223, Percent_Identity=30.4932735426009, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137530, Length=245, Percent_Identity=29.3877551020408, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17737895, Length=236, Percent_Identity=30.0847457627119, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221457811, Length=221, Percent_Identity=27.6018099547511, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 48070; Mature: 48070

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVYRGPNQVSVEEVEDPKIEHPADAIIRLTSSGICGSDLHMYEGRTVEKPGKVLGHE
CCEEEECCCCCCCHHHCCCCCCCCCHHHHEEEECCCCCCCCCEECCCCCCCCCCHHCCCC
PLGVIEEVGDAVTSFKKGDRVVVTFNIACGHCLNCIRGFTSACLTVNPESAGGAFGYAKM
CHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCC
GPYRGAQAEFLRVPFADLNCTKLPGSPGDKWEDDFIMLSDVFPTGFFATQLAMVMPGFPV
CCCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCE
AVFGAGPVGLLSAYSAILQGAAQVFVVDYIPERLKLAKSIGAIPVDFTLSDPVAMIEALR
EEECCCHHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
SQHSRVDTVLPGEEKLQGIMSSIENLAKSIGANLELARSDPVTMIQMLRAGNPAIVQSLI
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHC
PGEEKMKGVMSGIDAVGYQARDRQDPSRENPTQVISDLVRLINPTGHLGVIGVYVADDPG
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCC
AYNERAKKGEYILPFGQLWEKGISVGTGQTPVKKLQPMLRDMIIAGVAKPSFIVSHKISI
CCCHHHCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCC
EEAPDAYREFAKRSEGFTKVTIQFEK
CCCCHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKAVVYRGPNQVSVEEVEDPKIEHPADAIIRLTSSGICGSDLHMYEGRTVEKPGKVLGHE
CCEEEECCCCCCCHHHCCCCCCCCCHHHHEEEECCCCCCCCCEECCCCCCCCCCHHCCCC
PLGVIEEVGDAVTSFKKGDRVVVTFNIACGHCLNCIRGFTSACLTVNPESAGGAFGYAKM
CHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCC
GPYRGAQAEFLRVPFADLNCTKLPGSPGDKWEDDFIMLSDVFPTGFFATQLAMVMPGFPV
CCCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCE
AVFGAGPVGLLSAYSAILQGAAQVFVVDYIPERLKLAKSIGAIPVDFTLSDPVAMIEALR
EEECCCHHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
SQHSRVDTVLPGEEKLQGIMSSIENLAKSIGANLELARSDPVTMIQMLRAGNPAIVQSLI
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHC
PGEEKMKGVMSGIDAVGYQARDRQDPSRENPTQVISDLVRLINPTGHLGVIGVYVADDPG
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCC
AYNERAKKGEYILPFGQLWEKGISVGTGQTPVKKLQPMLRDMIIAGVAKPSFIVSHKISI
CCCHHHCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCC
EEAPDAYREFAKRSEGFTKVTIQFEK
CCCCHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]