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The map label for this gene is hppA

Identifier: 21226803

GI number: 21226803

Start: 843903

End: 845918

Strand: Direct

Name: hppA

Synonym: MM_0701

Alternate gene names: 21226803

Gene position: 843903-845918 (Clockwise)

Preceding gene: 21226801

Following gene: 21226804

Centisome position: 20.6

GC content: 48.76

Gene sequence:

>2016_bases
ATGGAAAGGTTAATATTCACTGCTCCTCTGGCAGGCTTAATAAGTCTGACCTTTGCCGCTTTTTTTGCAAAAAGCATCCT
GAAAGAAGACGCCGGCAATAAGAGGATGAAAGAAATTGCCGAAGCAATTAAGGAAGGATCCACAGCTTACATGAAGCGCC
AGTACAGAACGATTGCAGTGGTTTCTGTTATTATTTCGTTATTGATCCTATTTTTGCTTGACGAGGGGTTGAAAATAGCC
GCTGGTTTTCTGGCAGGTGCCATAAGTTCTGCTGCCGCGGGATATATAGGAATGAGCATCTCAGTCAGGGCAAATGTCCG
GACTGCCAGTGCTGCATCAGGAGGGGCCGGGAAAGCGCTGAAAATAGCATTCCGCGGAGGGGCTGTAACAGGACTTGCAG
TTATAGGGCTCGCACTTCTAGGAACAAGCAGTCTTTATATCCTCTATGGAGATGCTGACCTGGTTGTTGGTTTTGGTTTC
GGAGCCAGCCTTATAAGCCTTTTTGCCCGTGCAGGCGGCGGGATCTTTACAAAAGCAGCAGATGTGGGAGCTGACCTTGT
TGGAAAAATTGAAGCCGGAATTCCGGAAGACGATCCCAGAAACCCTGCTGTTATTGCAGATAATGTAGGAGACAATGTGG
GGGACTGTGCAGGTATGGGAGCAGACCTTTTTGAAACGTATGTGGTAACTTCACTTGCTGCCATGCTCCTCGGTTCTCTT
ATTATCGGCACTTACAAAAACGCCGTACTCTACCCTCTGATGCTCGGGTCTGCCGCAATCTTTGCATCCATTATATCCGT
ATTTTTTGTGAAGGTAGAAAAAGAAGGCAAAGTCATGAGTGCTCTCTACAGAGGCGTTGGCGGCTCTACGGTGCTCAGTT
TGATTGCTTTTTATTATATAACCGGTTTCCTGATGGGAGATAGCAGATTTTTCTATGTGACGGTCGCAGGCGTTGTAATT
ACAGTGCTCATGGTAATAGTAACCGAATATTACACTTCTAAAAGCTGCAGACCGGTAAAGACAATAGCAGTCTCTTCGGA
AACAGGAGCTGCAACCAATATAATTTCAGGGCTGTCAGCAGGATTTGAAAGCACCCTGGTACCTGCTGTAGTGATTGCTG
CAGGCATCCTGGTTTCGTACTTTATAGTGGGAGGATCTGCAGACCCCGGAACAGGGCTTTACGGAATCGCTATTGCATCC
GTTGCAATGCTCTCAACCGCAGGCATGATAGTTGCTCTGGACTCCTACGGGCCCATTACGGACAATGCAGGCGGAATTGC
ACAGATGGCAAACCTTCCGGCTCAGGTCAGAAAAGTTACGGACGAGCTAGATTCCGTGGGAAATACAACCAAAGCTGTTA
CCAAAGGATACGCCATAGGCTCGACAGCCCTGGGAGCACTTGCCCTGTTTGCGGACTACAGAAACAAAGTAAGCCTTGAG
AGCCAGTCTATCAGCCTCGACAGCCCTGTAGTGCTCTCAGGCATTCTTCTCGGAGCCGTACTTCCTTTTTTATTCAGCGC
TGTCATGATGAGTGCGGTGGGAAAAGCCGCCTTTGAAGTAGTAAATGAAGTCCGCAGGCAGTTCAGGGAAATCCCCGGGA
TTATGGAAGGTACCGCAAAGCCGGAATACGGGCGCTGCGTTGACATCGTAACAAAAGCAGCCCTTCACGATATGGCCATG
CCGGGCTTTCTTGCTGTTATCATCCCCCTTCTTACAGGATTTTTCCTGGGTCCTGAAGCACTGGCAGGGCTTCTTACAGG
GCTGATTGTAGTGGGGTTCATGCTTGCCCTCATGATGGACAACGGAGGAGGAGCCTGGGATAACGCAAAAAAACTGATTG
AAGATGGATATTACGGTGGGAAAGGTTCGGAAGCTCACAGAGCTGCAGTTGTCGGGGACACCGTAGGGGACCCTTTCAAA
GATACTGCGGGACCTGCCCTCAATTCCCTGATAAAGGTTGTTAACATGGTGGCAATTCTTTTCTCACCGCTTATAATAGG
CGGCGGCTTCTTATAA

Upstream 100 bases:

>100_bases
AGATAACCAAGGAGAATTACAGCTAAAGGACAGAAGTACTGGAAAGGACCACAAAACATGGGAATTTGAAGGAGTACAAA
TACCAGAGGATAGGAAATTT

Downstream 100 bases:

>100_bases
GAAGAACGTCGAGACTTCCCTATTCTATCAAATCCTGATTCTCATAACCTTCTGTTCAGAAGAATCATTTAATTTTATGA
AGTAAAAAAGGAGAGAATAA

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MERLIFTAPLAGLISLTFAAFFAKSILKEDAGNKRMKEIAEAIKEGSTAYMKRQYRTIAVVSVIISLLILFLLDEGLKIA
AGFLAGAISSAAAGYIGMSISVRANVRTASAASGGAGKALKIAFRGGAVTGLAVIGLALLGTSSLYILYGDADLVVGFGF
GASLISLFARAGGGIFTKAADVGADLVGKIEAGIPEDDPRNPAVIADNVGDNVGDCAGMGADLFETYVVTSLAAMLLGSL
IIGTYKNAVLYPLMLGSAAIFASIISVFFVKVEKEGKVMSALYRGVGGSTVLSLIAFYYITGFLMGDSRFFYVTVAGVVI
TVLMVIVTEYYTSKSCRPVKTIAVSSETGAATNIISGLSAGFESTLVPAVVIAAGILVSYFIVGGSADPGTGLYGIAIAS
VAMLSTAGMIVALDSYGPITDNAGGIAQMANLPAQVRKVTDELDSVGNTTKAVTKGYAIGSTALGALALFADYRNKVSLE
SQSISLDSPVVLSGILLGAVLPFLFSAVMMSAVGKAAFEVVNEVRRQFREIPGIMEGTAKPEYGRCVDIVTKAALHDMAM
PGFLAVIIPLLTGFFLGPEALAGLLTGLIVVGFMLALMMDNGGGAWDNAKKLIEDGYYGGKGSEAHRAAVVGDTVGDPFK
DTAGPALNSLIKVVNMVAILFSPLIIGGGFL

Sequences:

>Translated_671_residues
MERLIFTAPLAGLISLTFAAFFAKSILKEDAGNKRMKEIAEAIKEGSTAYMKRQYRTIAVVSVIISLLILFLLDEGLKIA
AGFLAGAISSAAAGYIGMSISVRANVRTASAASGGAGKALKIAFRGGAVTGLAVIGLALLGTSSLYILYGDADLVVGFGF
GASLISLFARAGGGIFTKAADVGADLVGKIEAGIPEDDPRNPAVIADNVGDNVGDCAGMGADLFETYVVTSLAAMLLGSL
IIGTYKNAVLYPLMLGSAAIFASIISVFFVKVEKEGKVMSALYRGVGGSTVLSLIAFYYITGFLMGDSRFFYVTVAGVVI
TVLMVIVTEYYTSKSCRPVKTIAVSSETGAATNIISGLSAGFESTLVPAVVIAAGILVSYFIVGGSADPGTGLYGIAIAS
VAMLSTAGMIVALDSYGPITDNAGGIAQMANLPAQVRKVTDELDSVGNTTKAVTKGYAIGSTALGALALFADYRNKVSLE
SQSISLDSPVVLSGILLGAVLPFLFSAVMMSAVGKAAFEVVNEVRRQFREIPGIMEGTAKPEYGRCVDIVTKAALHDMAM
PGFLAVIIPLLTGFFLGPEALAGLLTGLIVVGFMLALMMDNGGGAWDNAKKLIEDGYYGGKGSEAHRAAVVGDTVGDPFK
DTAGPALNSLIKVVNMVAILFSPLIIGGGFL
>Mature_671_residues
MERLIFTAPLAGLISLTFAAFFAKSILKEDAGNKRMKEIAEAIKEGSTAYMKRQYRTIAVVSVIISLLILFLLDEGLKIA
AGFLAGAISSAAAGYIGMSISVRANVRTASAASGGAGKALKIAFRGGAVTGLAVIGLALLGTSSLYILYGDADLVVGFGF
GASLISLFARAGGGIFTKAADVGADLVGKIEAGIPEDDPRNPAVIADNVGDNVGDCAGMGADLFETYVVTSLAAMLLGSL
IIGTYKNAVLYPLMLGSAAIFASIISVFFVKVEKEGKVMSALYRGVGGSTVLSLIAFYYITGFLMGDSRFFYVTVAGVVI
TVLMVIVTEYYTSKSCRPVKTIAVSSETGAATNIISGLSAGFESTLVPAVVIAAGILVSYFIVGGSADPGTGLYGIAIAS
VAMLSTAGMIVALDSYGPITDNAGGIAQMANLPAQVRKVTDELDSVGNTTKAVTKGYAIGSTALGALALFADYRNKVSLE
SQSISLDSPVVLSGILLGAVLPFLFSAVMMSAVGKAAFEVVNEVRRQFREIPGIMEGTAKPEYGRCVDIVTKAALHDMAM
PGFLAVIIPLLTGFFLGPEALAGLLTGLIVVGFMLALMMDNGGGAWDNAKKLIEDGYYGGKGSEAHRAAVVGDTVGDPFK
DTAGPALNSLIKVVNMVAILFSPLIIGGGFL

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA2_METMA (Q8PYZ7)

Other databases:

- EMBL:   AF312701
- EMBL:   AE008384
- RefSeq:   NP_632725.1
- GeneID:   1479043
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0701
- NMPDR:   fig|192952.1.peg.701
- HOGENOM:   HBG593668
- OMA:   FADYRNK
- ProtClustDB:   PRK00733
- BioCyc:   MMAZ192952:MM0701-MONOMER
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 69063; Mature: 69063

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbe3f9ec)-; HASH(0xd784f50)-; HASH(0xd25900c)-; HASH(0xd4aded4)-; HASH(0xc646d6c)-; HASH(0xd0e7818)-; HASH(0xc8f4c80)-; HASH(0xd348a8c)-; HASH(0xbe67678)-; HASH(0xd822328)-; HASH(0xd41daa4)-; HASH(0xc3a2b3c)-; HASH(0xd39f794)-; HASH(0xbfc3bc0)-; HASH(0xd48a690)-; HASH(0xd3d18e0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLIFTAPLAGLISLTFAAFFAKSILKEDAGNKRMKEIAEAIKEGSTAYMKRQYRTIAV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
VSVIISLLILFLLDEGLKIAAGFLAGAISSAAAGYIGMSISVRANVRTASAASGGAGKAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEECCCCCCCCCCEE
KIAFRGGAVTGLAVIGLALLGTSSLYILYGDADLVVGFGFGASLISLFARAGGGIFTKAA
EEEECCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHCCCCCEEHHH
DVGADLVGKIEAGIPEDDPRNPAVIADNVGDNVGDCAGMGADLFETYVVTSLAAMLLGSL
HHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIGTYKNAVLYPLMLGSAAIFASIISVFFVKVEKEGKVMSALYRGVGGSTVLSLIAFYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
TGFLMGDSRFFYVTVAGVVITVLMVIVTEYYTSKSCRPVKTIAVSSETGAATNIISGLSA
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GFESTLVPAVVIAAGILVSYFIVGGSADPGTGLYGIAIASVAMLSTAGMIVALDSYGPIT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCC
DNAGGIAQMANLPAQVRKVTDELDSVGNTTKAVTKGYAIGSTALGALALFADYRNKVSLE
CCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
SQSISLDSPVVLSGILLGAVLPFLFSAVMMSAVGKAAFEVVNEVRRQFREIPGIMEGTAK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCC
PEYGRCVDIVTKAALHDMAMPGFLAVIIPLLTGFFLGPEALAGLLTGLIVVGFMLALMMD
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
NGGGAWDNAKKLIEDGYYGGKGSEAHRAAVVGDTVGDPFKDTAGPALNSLIKVVNMVAIL
CCCCCCHHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FSPLIIGGGFL
HHHHHHCCCCH
>Mature Secondary Structure
MERLIFTAPLAGLISLTFAAFFAKSILKEDAGNKRMKEIAEAIKEGSTAYMKRQYRTIAV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
VSVIISLLILFLLDEGLKIAAGFLAGAISSAAAGYIGMSISVRANVRTASAASGGAGKAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEECCCCCCCCCCEE
KIAFRGGAVTGLAVIGLALLGTSSLYILYGDADLVVGFGFGASLISLFARAGGGIFTKAA
EEEECCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHCCCCCEEHHH
DVGADLVGKIEAGIPEDDPRNPAVIADNVGDNVGDCAGMGADLFETYVVTSLAAMLLGSL
HHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIGTYKNAVLYPLMLGSAAIFASIISVFFVKVEKEGKVMSALYRGVGGSTVLSLIAFYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
TGFLMGDSRFFYVTVAGVVITVLMVIVTEYYTSKSCRPVKTIAVSSETGAATNIISGLSA
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GFESTLVPAVVIAAGILVSYFIVGGSADPGTGLYGIAIASVAMLSTAGMIVALDSYGPIT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCC
DNAGGIAQMANLPAQVRKVTDELDSVGNTTKAVTKGYAIGSTALGALALFADYRNKVSLE
CCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
SQSISLDSPVVLSGILLGAVLPFLFSAVMMSAVGKAAFEVVNEVRRQFREIPGIMEGTAK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCC
PEYGRCVDIVTKAALHDMAMPGFLAVIIPLLTGFFLGPEALAGLLTGLIVVGFMLALMMD
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
NGGGAWDNAKKLIEDGYYGGKGSEAHRAAVVGDTVGDPFKDTAGPALNSLIKVVNMVAIL
CCCCCCHHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FSPLIIGGGFL
HHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12125824