Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 21226720

GI number: 21226720

Start: 749737

End: 750711

Strand: Direct

Name: uppS [H]

Synonym: MM_0618

Alternate gene names: 21226720

Gene position: 749737-750711 (Clockwise)

Preceding gene: 21226719

Following gene: 21226721

Centisome position: 18.3

GC content: 45.33

Gene sequence:

>975_bases
TTGCCAGGGGGAAAAGAAATAATTAACCTTAAAATGGGATCATTGAATAAAGGAGCCTTTCAGGCAGGGCTTCGCTTCAT
GAAAAATCGGACTTTCAGTGTGTTCTACCGGAAATACGAGCAGATCCTGGAAAAGGAGATTCTGAGTTCTGAAATTCCCG
AGCACATAGCTGTAATTATGGACGGAAACCGCAGATACGCCGGACAGCTGGGAAAAGCCCGAATTTTCGGACACGCTATG
GGAGCAGAAGTTACTGAGCAGGTTATTGAATGGTGCTATGAGATAGGAGTAAAACAGCTTACTCTCTATGCCTTTTCCAC
GGAAAATTTCCAGCGTTCGGAAGAAGAGGTCGGTGGGCTCTTTAACCTTATCAATGAGAAATTTTTGAAGCTTCATACTG
ATAAGAGAACTTATGAAAAAGAGATGCAGGTCAGAGTTATAGGGGACAGAACAAAACTGCCTGCATACCTGAACGAATCC
ATTGACAGAATTGAGAAAGCCACGGAGCATCACAGGAAATTCAGCCTGAATGTGGCTATTGCTTATGGTGGAAGGCAGGA
TATAATGCAGGCTGTAAGGGATATCGCAACCTGTGTATCCAGCGGGAAACTTTCTCTGGAAGATGTTAACGAAAGCCTGA
TCTCAAAACACCTCTATCCTGCCCCCGGAGTCCCTGTCCCCAATGTGGACCTGATCATCCGCACCGGAGGGGATGAGAGA
ATATCAAACTTCCTTCCCTGGCAGGCTAACGGCAGTGAATGTGCAACTTATTTCTGCGCTCCTTTCTGGCCCGAGTTCCG
AAAAATCGACCTCCTTCGTTCTGTCAGAGTTTATCAGGCCAGAAAAGAAGAAAAGAAACGTGAGCATTCGTATCGCATCT
CAAAAGTTAAGAACTTTCTCAGGGTAGGGAAATATGAGAATAAAAGTGAAGACCTGGGACAGCTCCTTCCTTTAAAAAAG
CAGGGAGTCTCCTGA

Upstream 100 bases:

>100_bases
TAAAATTTAGCTTTCCAAATATGTGAAAAATTTAATACCACACCGCAAAAAATGTATATGAATATTCCTGTTACCTATAA
TATTCCTGTTATCTATCATA

Downstream 100 bases:

>100_bases
GCTACTTAAAGCTTTGGGGAAAGACTGGGACTGAATTAAGAACAGCAATTAATCCCATTCTTAACCTGGATCTTTACACT
CATTATAAAAACTCTTTTTT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPGGKEIINLKMGSLNKGAFQAGLRFMKNRTFSVFYRKYEQILEKEILSSEIPEHIAVIMDGNRRYAGQLGKARIFGHAM
GAEVTEQVIEWCYEIGVKQLTLYAFSTENFQRSEEEVGGLFNLINEKFLKLHTDKRTYEKEMQVRVIGDRTKLPAYLNES
IDRIEKATEHHRKFSLNVAIAYGGRQDIMQAVRDIATCVSSGKLSLEDVNESLISKHLYPAPGVPVPNVDLIIRTGGDER
ISNFLPWQANGSECATYFCAPFWPEFRKIDLLRSVRVYQARKEEKKREHSYRISKVKNFLRVGKYENKSEDLGQLLPLKK
QGVS

Sequences:

>Translated_324_residues
MPGGKEIINLKMGSLNKGAFQAGLRFMKNRTFSVFYRKYEQILEKEILSSEIPEHIAVIMDGNRRYAGQLGKARIFGHAM
GAEVTEQVIEWCYEIGVKQLTLYAFSTENFQRSEEEVGGLFNLINEKFLKLHTDKRTYEKEMQVRVIGDRTKLPAYLNES
IDRIEKATEHHRKFSLNVAIAYGGRQDIMQAVRDIATCVSSGKLSLEDVNESLISKHLYPAPGVPVPNVDLIIRTGGDER
ISNFLPWQANGSECATYFCAPFWPEFRKIDLLRSVRVYQARKEEKKREHSYRISKVKNFLRVGKYENKSEDLGQLLPLKK
QGVS
>Mature_323_residues
PGGKEIINLKMGSLNKGAFQAGLRFMKNRTFSVFYRKYEQILEKEILSSEIPEHIAVIMDGNRRYAGQLGKARIFGHAMG
AEVTEQVIEWCYEIGVKQLTLYAFSTENFQRSEEEVGGLFNLINEKFLKLHTDKRTYEKEMQVRVIGDRTKLPAYLNESI
DRIEKATEHHRKFSLNVAIAYGGRQDIMQAVRDIATCVSSGKLSLEDVNESLISKHLYPAPGVPVPNVDLIIRTGGDERI
SNFLPWQANGSECATYFCAPFWPEFRKIDLLRSVRVYQARKEEKKREHSYRISKVKNFLRVGKYENKSEDLGQLLPLKKQ
GVS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=242, Percent_Identity=38.8429752066116, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI45580742, Length=242, Percent_Identity=38.8429752066116, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786371, Length=240, Percent_Identity=37.0833333333333, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71993029, Length=259, Percent_Identity=38.6100386100386, Blast_Score=173, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6319474, Length=224, Percent_Identity=33.9285714285714, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=263, Percent_Identity=31.1787072243346, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18857969, Length=255, Percent_Identity=38.0392156862745, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 37162; Mature: 37031

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGGKEIINLKMGSLNKGAFQAGLRFMKNRTFSVFYRKYEQILEKEILSSEIPEHIAVIM
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEE
DGNRRYAGQLGKARIFGHAMGAEVTEQVIEWCYEIGVKQLTLYAFSTENFQRSEEEVGGL
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHH
FNLINEKFLKLHTDKRTYEKEMQVRVIGDRTKLPAYLNESIDRIEKATEHHRKFSLNVAI
HHHHHHHHHHHHCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEE
AYGGRQDIMQAVRDIATCVSSGKLSLEDVNESLISKHLYPAPGVPVPNVDLIIRTGGDER
EECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHH
ISNFLPWQANGSECATYFCAPFWPEFRKIDLLRSVRVYQARKEEKKREHSYRISKVKNFL
HHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGKYENKSEDLGQLLPLKKQGVS
HHCCCCCCHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
PGGKEIINLKMGSLNKGAFQAGLRFMKNRTFSVFYRKYEQILEKEILSSEIPEHIAVIM
CCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEE
DGNRRYAGQLGKARIFGHAMGAEVTEQVIEWCYEIGVKQLTLYAFSTENFQRSEEEVGGL
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHH
FNLINEKFLKLHTDKRTYEKEMQVRVIGDRTKLPAYLNESIDRIEKATEHHRKFSLNVAI
HHHHHHHHHHHHCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEE
AYGGRQDIMQAVRDIATCVSSGKLSLEDVNESLISKHLYPAPGVPVPNVDLIIRTGGDER
EECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHH
ISNFLPWQANGSECATYFCAPFWPEFRKIDLLRSVRVYQARKEEKKREHSYRISKVKNFL
HHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGKYENKSEDLGQLLPLKKQGVS
HHCCCCCCHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]