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The map label for this gene is gcp [H]

Identifier: 21226704

GI number: 21226704

Start: 733754

End: 735442

Strand: Direct

Name: gcp [H]

Synonym: MM_0602

Alternate gene names: 21226704

Gene position: 733754-735442 (Clockwise)

Preceding gene: 21226703

Following gene: 21226705

Centisome position: 17.91

GC content: 49.26

Gene sequence:

>1689_bases
GTGACAGTAAGCAGAGGAAAAGGAACGGAAAGGAGACCTGAAGCCTTGAAAAAAACATTCATCCTTGGAATCGAAGGCAC
TGCCTGGAACCTGAGTGCCGCAATCGTGACCGAGACCGAGATCATTGCCGAGGTTACAGAGACATATAAACCTGAAAAAG
GCGGAATCCACCCCAGGGAAGCCGCCCAGCACCATGCAAAATATGCGGCAGGCGTTATCAAAAAACTCCTTGCAGAAGCA
AAGCAAAACGGGATAGAGCCGTCAGACCTCGACGGCATAGCTTTTTCACAGGGGCCTGGACTTGGGCCGTGCTTAAGGAC
CGTTGCAACGGCAGCCAGGATGCTCGGCCTTTCCCTTGGCATCCCGCTTATAGGAGTCAACCACTGTATTGCACATATTG
AGATAGGGATCTGGAAAACTCCTGCAAAGGACCCTGTTGTGCTCTATGTGAGCGGGGCAAATTCCCAGGTAATCTCTTAT
ATGGAAGGGAGGTACAGGGTTTTTGGAGAAACCCTTGATATAGGACTTGGAAATGCCCTTGATAAATTCGCTCGCGGAGC
AGGCTTGCCTCACCCGGGTGGGCCCAAAATCGAGGCATATGCAAAAGAAGCAAAGAGATATATCCCTCTCCCGTACGTGA
TTAAAGGTATGGACCTCTCATTTTCCGGGCTTTCAACAGCTGCAAGTGAAGCCCTGAGAAAAGCCTCCCTTGAAGATGTC
TGTTATTCTTATCAGGAGACTGCCTTTGCAATGGTTGTGGAGGTTGCAGAACGCGCCCTTGCCCATACAGGAAAAAAAGA
AGTGCTGCTTGCAGGCGGGGTGGGAGCAAACACCAGGCTTCGTGAGATGTTAAATGAAATGTGTGAAGCCAGAGGTGCAA
AGTTCTATGTTCCCGAAAAACGCTTTATGGGCGACAACGGGACAATGATCGCATACACAGGGCTCCTGATGTATAAGTCC
GGAAATACCATTTCCCTTGAAGATTCGCGCGTAAACCCCAGTTTCAGGACAGATGATGTCAAAGTGACATGGATAAAGGA
AGAAGAGATGAAAAAGGTCCCTGAAATCTCCCCTGAAACTTTCTTCAGGATGCCTCCCGGGGAAATTCTCGACAACGGGG
CTGAAGCTGTTGTCTACCTTCAAGAGGGACCTGAAGGTAAGAGGGCGCTGGTCAAGGAAAGGGTCCCAAAGGCTTACAGG
CATAAAGAGATAGACGAGAGGATAAGAAGAGAGAGGAACAGGACAGAAGCCCGCCTTATGTCTGAAGCCAGGCGCGCAGG
CGTGCCCACTCCAATCATCTATGACGTTGAGGAATTCAAGCTTAAAATGCAGTTCATCGAAGGGGTCCCCATAAAGTACC
TTATAACCCCCCCACTTTCGGAAAAGGTTGGAGAGCTCGTGGGCAAACTGCACAGTTCAGGCATCGTACATGGAGACCTT
ACAACCTCAAACCTCCTGCTTGCAGGTGAGAGGCTTTATCTTATCGACTTCGGGCTTGCGTATTTTGACAAAAGCCTTGA
AGCCAGAGGTGTGGACGTCCATGTGCTTTTCCAGACTTTTGAGAGCACTCACCGCAACTATGAAGCCCTTGTCAAAGCTT
TCGAGAAAGGGTATGCAAGTACTTTTATAGATTCAGAGGATGTACTCAGGCGAGTTGAAGAGATAAAAAAGAGGGCTCGC
TATGCATAA

Upstream 100 bases:

>100_bases
AAAACTTGGAAAATTTTAAAGCAGTAAAAAATGCTCAAAAATATTCCGCAGGTATCAAAAAAGCAAATGTATATAATCCT
CTCCTGTATTATCGAAGGCA

Downstream 100 bases:

>100_bases
GATCGTTTTTGTTACGGGAAATAAAGGCAAATTTGCCGAGGTGAGGGATATCCTCAAGAATTTCGGAATCGAAGCCATCC
AGAATAAAGACGGTTATCCC

Product: O-sialoglycoprotein endopeptidase/protein kinase

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTVSRGKGTERRPEALKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPREAAQHHAKYAAGVIKKLLAEA
KQNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLGIPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISY
MEGRYRVFGETLDIGLGNALDKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDV
CYSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEKRFMGDNGTMIAYTGLLMYKS
GNTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPETFFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYR
HKEIDERIRRERNRTEARLMSEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDL
TTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYASTFIDSEDVLRRVEEIKKRAR
YA

Sequences:

>Translated_562_residues
MTVSRGKGTERRPEALKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPREAAQHHAKYAAGVIKKLLAEA
KQNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLGIPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISY
MEGRYRVFGETLDIGLGNALDKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDV
CYSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEKRFMGDNGTMIAYTGLLMYKS
GNTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPETFFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYR
HKEIDERIRRERNRTEARLMSEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDL
TTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYASTFIDSEDVLRRVEEIKKRAR
YA
>Mature_561_residues
TVSRGKGTERRPEALKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPREAAQHHAKYAAGVIKKLLAEAK
QNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLGIPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISYM
EGRYRVFGETLDIGLGNALDKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDVC
YSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEKRFMGDNGTMIAYTGLLMYKSG
NTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPETFFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYRH
KEIDERIRRERNRTEARLMSEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDLT
TSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYASTFIDSEDVLRRVEEIKKRARY
A

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI8923380, Length=335, Percent_Identity=45.9701492537313, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI41327715, Length=212, Percent_Identity=35.8490566037736, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI116812636, Length=343, Percent_Identity=28.8629737609329, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1789445, Length=323, Percent_Identity=33.1269349845201, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71995670, Length=336, Percent_Identity=44.9404761904762, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322891, Length=368, Percent_Identity=42.1195652173913, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6320099, Length=367, Percent_Identity=25.6130790190736, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321701, Length=234, Percent_Identity=31.1965811965812, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357207, Length=344, Percent_Identity=47.093023255814, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24658177, Length=219, Percent_Identity=33.7899543378995, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129063, Length=371, Percent_Identity=26.9541778975741, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022449
- InterPro:   IPR022495
- InterPro:   IPR011009
- InterPro:   IPR009220
- InterPro:   IPR000905
- InterPro:   IPR017861
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR008266 [H]

Pfam domain/function: PF00814 Peptidase_M22; PF01163 RIO1 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 62172; Mature: 62041

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSRGKGTERRPEALKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPRE
CCCCCCCCCCCHHHHHHHEEEEEECCCCEECEEEEEEHHHHHHHHHHHCCCCCCCCCHHH
AAQHHAKYAAGVIKKLLAEAKQNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
IPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISYMEGRYRVFGETLDIGLGNAL
CCHHHHHHHHEEEEEEEEECCCCCCEEEEEECCCCHHHHHHCCCCEEECCHHCCCCCHHH
DKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDV
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH
CYSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCHH
RFMGDNGTMIAYTGLLMYKSGNTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPET
HHCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECHHHHHCCCCCCCHH
FFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYRHKEIDERIRRERNRTEARLM
EEECCCHHHHCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDL
HHHHHCCCCCCEEECHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCEEECCC
TTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYAS
CCCCEEEECCEEEEEEHHHHHHCCCHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCHHH
TFIDSEDVLRRVEEIKKRARYA
HCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVSRGKGTERRPEALKKTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEKGGIHPRE
CCCCCCCCCCHHHHHHHEEEEEECCCCEECEEEEEEHHHHHHHHHHHCCCCCCCCCHHH
AAQHHAKYAAGVIKKLLAEAKQNGIEPSDLDGIAFSQGPGLGPCLRTVATAARMLGLSLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
IPLIGVNHCIAHIEIGIWKTPAKDPVVLYVSGANSQVISYMEGRYRVFGETLDIGLGNAL
CCHHHHHHHHEEEEEEEEECCCCCCEEEEEECCCCHHHHHHCCCCEEECCHHCCCCCHHH
DKFARGAGLPHPGGPKIEAYAKEAKRYIPLPYVIKGMDLSFSGLSTAASEALRKASLEDV
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH
CYSYQETAFAMVVEVAERALAHTGKKEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCHH
RFMGDNGTMIAYTGLLMYKSGNTISLEDSRVNPSFRTDDVKVTWIKEEEMKKVPEISPET
HHCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECHHHHHCCCCCCCHH
FFRMPPGEILDNGAEAVVYLQEGPEGKRALVKERVPKAYRHKEIDERIRRERNRTEARLM
EEECCCHHHHCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SEARRAGVPTPIIYDVEEFKLKMQFIEGVPIKYLITPPLSEKVGELVGKLHSSGIVHGDL
HHHHHCCCCCCEEECHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCEEECCC
TTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRNYEALVKAFEKGYAS
CCCCEEEECCEEEEEEHHHHHHCCCHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCHHH
TFIDSEDVLRRVEEIKKRARYA
HCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]