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The map label for this gene is yggV [C]

Identifier: 21226705

GI number: 21226705

Start: 735435

End: 735989

Strand: Direct

Name: yggV [C]

Synonym: MM_0603

Alternate gene names: 21226705

Gene position: 735435-735989 (Clockwise)

Preceding gene: 21226704

Following gene: 21226707

Centisome position: 17.95

GC content: 49.19

Gene sequence:

>555_bases
ATGCATAAGATCGTTTTTGTTACGGGAAATAAAGGCAAATTTGCCGAGGTGAGGGATATCCTCAAGAATTTCGGAATCGA
AGCCATCCAGAATAAAGACGGTTATCCCGAACTCCAGGAAGATGAACTTGAACCTATCGCTGCTAACGGGGCACAGTATG
TTGCAAACAAACTGAACATGCCCGTAATGGTAGACGACTCAGGAATATTCATAAATGCCCTGAACGGCTTTCCGGGACCC
TATTCCCGCTTTGTGGAAGACAAACTGGGGAACCCGAAAGTGCTGAAGCTCATGGAAGGAGAGAAAGACAGGTCAGCGTA
TTTCAAAACCGTGATTGGATATTGTGAACCGGGACAGGAGCCTCTGGTCTTCCCCGGGGTCGTGGAAGGGAAGATCGCAT
ACGAAGAGCGCGGAACAGGCGGTTTCGGTTACGACCCTATTTTCGAGTATAACGGCATGACCTTCGGGGAACTCGGGGAT
GAAGAGAAAAACAAGGTTTCCCATAGGCGCAGGGCTGTTGATAATTTCCTGGAGTGGTTCATAGGCGGGGCGTAA

Upstream 100 bases:

>100_bases
GAAGCCCTTGTCAAAGCTTTCGAGAAAGGGTATGCAAGTACTTTTATAGATTCAGAGGATGTACTCAGGCGAGTTGAAGA
GATAAAAAAGAGGGCTCGCT

Downstream 100 bases:

>100_bases
AACCCCTGCACTTAAAAAATTTGAAATTTCAGGAATGACCTTTTCACGTCCCTCAAACTTACTTTTTCACTTCTTCTCTA
CTGGTTTGTGCCTTACAAGG

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MHKIVFVTGNKGKFAEVRDILKNFGIEAIQNKDGYPELQEDELEPIAANGAQYVANKLNMPVMVDDSGIFINALNGFPGP
YSRFVEDKLGNPKVLKLMEGEKDRSAYFKTVIGYCEPGQEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYNGMTFGELGD
EEKNKVSHRRRAVDNFLEWFIGGA

Sequences:

>Translated_184_residues
MHKIVFVTGNKGKFAEVRDILKNFGIEAIQNKDGYPELQEDELEPIAANGAQYVANKLNMPVMVDDSGIFINALNGFPGP
YSRFVEDKLGNPKVLKLMEGEKDRSAYFKTVIGYCEPGQEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYNGMTFGELGD
EEKNKVSHRRRAVDNFLEWFIGGA
>Mature_184_residues
MHKIVFVTGNKGKFAEVRDILKNFGIEAIQNKDGYPELQEDELEPIAANGAQYVANKLNMPVMVDDSGIFINALNGFPGP
YSRFVEDKLGNPKVLKLMEGEKDRSAYFKTVIGYCEPGQEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYNGMTFGELGD
EEKNKVSHRRRAVDNFLEWFIGGA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=183, Percent_Identity=37.1584699453552, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI31657144, Length=162, Percent_Identity=33.9506172839506, Blast_Score=88, Evalue=4e-18,
Organism=Escherichia coli, GI1789324, Length=197, Percent_Identity=38.0710659898477, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17556833, Length=185, Percent_Identity=35.1351351351351, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322529, Length=190, Percent_Identity=35.2631578947368, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19920712, Length=181, Percent_Identity=39.2265193370166, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 20525; Mature: 20525

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIVFVTGNKGKFAEVRDILKNFGIEAIQNKDGYPELQEDELEPIAANGAQYVANKLNM
CCEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
PVMVDDSGIFINALNGFPGPYSRFVEDKLGNPKVLKLMEGEKDRSAYFKTVIGYCEPGQE
CEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
PLVFPGVVEGKIAYEERGTGGFGYDPIFEYNGMTFGELGDEEKNKVSHRRRAVDNFLEWF
CEEECCCCCCEEEEECCCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
IGGA
HCCC
>Mature Secondary Structure
MHKIVFVTGNKGKFAEVRDILKNFGIEAIQNKDGYPELQEDELEPIAANGAQYVANKLNM
CCEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
PVMVDDSGIFINALNGFPGPYSRFVEDKLGNPKVLKLMEGEKDRSAYFKTVIGYCEPGQE
CEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
PLVFPGVVEGKIAYEERGTGGFGYDPIFEYNGMTFGELGDEEKNKVSHRRRAVDNFLEWF
CEEECCCCCCEEEEECCCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
IGGA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]