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The map label for this gene is 21226341

Identifier: 21226341

GI number: 21226341

Start: 321496

End: 322308

Strand: Reverse

Name: 21226341

Synonym: MM_0239

Alternate gene names: NA

Gene position: 322308-321496 (Counterclockwise)

Preceding gene: 21226342

Following gene: 21226339

Centisome position: 7.87

GC content: 49.45

Gene sequence:

>813_bases
ATGAAAATCCTCGTGCTTTATTCAGGCGAACTGGGAAAAAAAGTTATCCAGAATCTGGTGAACTCATCAAGTTTCTGTGT
GTCCTGTGGTGAGCTCTGCAACCACTGTCGTCAGGCAAGGAAATCTTATGCGAACCTGATCGTAGGAATCCATGAGTTTG
CAGATGACCTTCCGGCATTTATTGAAGAGCCTGCCCAGTATATGCCTCCGAATCTTCCTGAATGCGATCTGATCCTTGCA
ATAGGCATACACCCCGACCTGTTTGCAGCCATTCCCGAAGTTGTGCAGAAAACGGGGGCAAAAGCCGTAATTGCACCGTC
CGAGGACTCAAAGAAGACTCCTGCCGGCGTCCTTGAGCAGCTCAGAAAAGAACTCGAAGCCATGGGTATCGAATTTGAGG
CTCCAAAACCTTTCTGTGCTCTTGATAAGACCGGAAAGCCGGTAATAGACTCTTTCGTGGACCTCGGTTTCGGAAGGCCT
GTACTGAGGATAGAGATGAGCCCTGACGGAAAAATGTTCATAGGAGCGGGTGTACTCAGGGACGCACCCTGCGGCTCAAC
CTGGTTTGTCGCAAAAAAACTCGGCTGGACCGATGTTTCGGGATATAAAGAAACCATCTCAGGCGCCCACCATTCTTACC
CCTGCACAGCAAGCATGGACAAAGATCCCCAGATCGGAGATACCATCCTGCACAAAGCCGGATATATCATCAGGGAGGCT
GTGGAAGAAGGCATGGAATGCGCAAAAAAGGAGAAAGAAAAGTTTTCGACAGCCTGCAGTGATGAGGCCCAGGCTCTGGC
TTTTGAAAATTAA

Upstream 100 bases:

>100_bases
ATATTTTTTTCATTATGGGAGATAAAAAGTGGAGGTAATTTTCACGAAGAAAACGAATTTGTGAAATGGCTTTGAAATCC
TTGAAAGGGGGAATAATAAT

Downstream 100 bases:

>100_bases
ACCGGAAACGATGAAGGCACTCCTTCCCGTGCCTTCCCTTCTTTTACCGGGCAAAAAGCTTCCGGCGAATTAAATAAACA
TTCACCTGAGTTCTGTATAA

Product: hypothetical protein

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKILVLYSGELGKKVIQNLVNSSSFCVSCGELCNHCRQARKSYANLIVGIHEFADDLPAFIEEPAQYMPPNLPECDLILA
IGIHPDLFAAIPEVVQKTGAKAVIAPSEDSKKTPAGVLEQLRKELEAMGIEFEAPKPFCALDKTGKPVIDSFVDLGFGRP
VLRIEMSPDGKMFIGAGVLRDAPCGSTWFVAKKLGWTDVSGYKETISGAHHSYPCTASMDKDPQIGDTILHKAGYIIREA
VEEGMECAKKEKEKFSTACSDEAQALAFEN

Sequences:

>Translated_270_residues
MKILVLYSGELGKKVIQNLVNSSSFCVSCGELCNHCRQARKSYANLIVGIHEFADDLPAFIEEPAQYMPPNLPECDLILA
IGIHPDLFAAIPEVVQKTGAKAVIAPSEDSKKTPAGVLEQLRKELEAMGIEFEAPKPFCALDKTGKPVIDSFVDLGFGRP
VLRIEMSPDGKMFIGAGVLRDAPCGSTWFVAKKLGWTDVSGYKETISGAHHSYPCTASMDKDPQIGDTILHKAGYIIREA
VEEGMECAKKEKEKFSTACSDEAQALAFEN
>Mature_270_residues
MKILVLYSGELGKKVIQNLVNSSSFCVSCGELCNHCRQARKSYANLIVGIHEFADDLPAFIEEPAQYMPPNLPECDLILA
IGIHPDLFAAIPEVVQKTGAKAVIAPSEDSKKTPAGVLEQLRKELEAMGIEFEAPKPFCALDKTGKPVIDSFVDLGFGRP
VLRIEMSPDGKMFIGAGVLRDAPCGSTWFVAKKLGWTDVSGYKETISGAHHSYPCTASMDKDPQIGDTILHKAGYIIREA
VEEGMECAKKEKEKFSTACSDEAQALAFEN

Specific function: Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i.e. a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2.1.1.45). However, M.jannaschii like most methanogenic Archaea lacks

COG id: COG1810

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003745 [H]

Pfam domain/function: PF02593 DUF166 [H]

EC number: NA

Molecular weight: Translated: 29370; Mature: 29370

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVLYSGELGKKVIQNLVNSSSFCVSCGELCNHCRQARKSYANLIVGIHEFADDLPAF
CEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEPAQYMPPNLPECDLILAIGIHPDLFAAIPEVVQKTGAKAVIAPSEDSKKTPAGVLEQ
HHCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHH
LRKELEAMGIEFEAPKPFCALDKTGKPVIDSFVDLGFGRPVLRIEMSPDGKMFIGAGVLR
HHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
DAPCGSTWFVAKKLGWTDVSGYKETISGAHHSYPCTASMDKDPQIGDTILHKAGYIIREA
CCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VEEGMECAKKEKEKFSTACSDEAQALAFEN
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MKILVLYSGELGKKVIQNLVNSSSFCVSCGELCNHCRQARKSYANLIVGIHEFADDLPAF
CEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEPAQYMPPNLPECDLILAIGIHPDLFAAIPEVVQKTGAKAVIAPSEDSKKTPAGVLEQ
HHCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHH
LRKELEAMGIEFEAPKPFCALDKTGKPVIDSFVDLGFGRPVLRIEMSPDGKMFIGAGVLR
HHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
DAPCGSTWFVAKKLGWTDVSGYKETISGAHHSYPCTASMDKDPQIGDTILHKAGYIIREA
CCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VEEGMECAKKEKEKFSTACSDEAQALAFEN
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]