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The map label for this gene is pth [H]

Identifier: 21226214

GI number: 21226214

Start: 138650

End: 139024

Strand: Direct

Name: pth [H]

Synonym: MM_0112

Alternate gene names: 21226214

Gene position: 138650-139024 (Clockwise)

Preceding gene: 21226213

Following gene: 21226215

Centisome position: 3.38

GC content: 45.6

Gene sequence:

>375_bases
TTGCCTTTGAATAGTCAGAGGCAAAAGATGAGTGAATACAAACAGTGTATAGTTACCCGGGACGACCTGAAACTTTCGAA
AGGCAAATTTGCTGTACAGGTGGCTCACGCTGCCCTTTCTGCAGCTGAATGGGCAAGTAAAGGCGACCTTGAAAAATGGA
AAGAAGGAGGGCAAAAGAAAATTGTCCTGAAAGTCCCGAGCATTAAGGAACTTTATGAGCTTAAAGAGAAAGCAAGGCGG
GAAGGGCTCCCTACTGCTCTTATACAGGACGCGGGCCTTACTGAGATCCCTCCCGGAACCGTTACAGTACTCGGGATAGG
GCCGGCAAAAGAAGAGCTTATAGATAAAATTACAAAAGACCTTAAACTCGTTTAA

Upstream 100 bases:

>100_bases
ATTATCCTGAGGACAATCGGTCAAGAAAAAGTTATTGAAATTTTAAGACAGATCCGGATTTCCAGCCGGAAAGACCGCAC
AGAAAACATTAAGATATAGG

Downstream 100 bases:

>100_bases
CTTCAGGATTTCCGGGTAAAAAAATATAGTCAAGTTTAAAAAGCCAGCAAAGGATATCAGAAGAGATGTTTTCACAGACA
GGAAAAAAATTCTGCCTGCT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MPLNSQRQKMSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKKIVLKVPSIKELYELKEKARR
EGLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKDLKLV

Sequences:

>Translated_124_residues
MPLNSQRQKMSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKKIVLKVPSIKELYELKEKARR
EGLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKDLKLV
>Mature_123_residues
PLNSQRQKMSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKKIVLKVPSIKELYELKEKARRE
GLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKDLKLV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family [H]

Homologues:

Organism=Homo sapiens, GI7706351, Length=115, Percent_Identity=48.695652173913, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558188, Length=117, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319414, Length=121, Percent_Identity=42.9752066115703, Blast_Score=90, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=42.7350427350427, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281376919, Length=116, Percent_Identity=41.3793103448276, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644665, Length=116, Percent_Identity=41.3793103448276, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002833 [H]

Pfam domain/function: PF01981 PTH2 [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 13695; Mature: 13564

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNSQRQKMSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKK
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEE
IVLKVPSIKELYELKEKARREGLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKD
EEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LKLV
HCCC
>Mature Secondary Structure 
PLNSQRQKMSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKK
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEE
IVLKVPSIKELYELKEKARREGLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKD
EEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LKLV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]