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The map label for this gene is argF [H]

Identifier: 161485684

GI number: 161485684

Start: 180118

End: 181026

Strand: Direct

Name: argF [H]

Synonym: MM_0145

Alternate gene names: 161485684

Gene position: 180118-181026 (Clockwise)

Preceding gene: 21226246

Following gene: 21226248

Centisome position: 4.4

GC content: 49.39

Gene sequence:

>909_bases
ATGAAGAGAGATGTACTTTCTATAACTGACCTGTCCAGGGAGGAGATATACGAACTCCTTGAATCGGCAGCGGACCTGAA
GAAAAAACGTAAGGCGGGAGAACCTACCGAGTACCTGAAACATAAAAGCCTTGGAATGATTTTCGAAAAATCCTCCACAA
GGACAAGGGTATCCTTTGAGGTTGCAATGAGCGATTTCGGAGGACACGCCCTTTACCTTAACTCCAGGGATATCCAGGTA
GGAAGAGGTGAGACAATTGAAGATACAGCCAGGACCCTTTCGGGATACCTGCACGGGATCATGGCAAGGGTTATGAGCCA
TGACACCGTGGAAAAGCTTGCCAGATTCTCGACCATACCCGTGATAAATGCCCTCTCGGACCGGGAACACCCATGCCAGA
TCCTTGGCGATTTCATGACCATCATGGAATATAAAAACAGGTTTGAAGGCCTGAAGTTCGCCTGGATAGGAGACGGGAAC
AATGTCTGCAATTCCGCTCTCCTGGGCTCTGCAATCATGGGAATGGAGTTTGTCATTGCCTGCCCTGAAGGTTACGAACC
CGGAGCCGAGTTCCTCGAGAAAGCGAAAGCCCTGGGAGGCAAATTCTCAATAACAGATGACCCCAAAACTGCCGCAAAAG
ACGCAGATATAATCTATACTGATGTCTGGGTCTCCATGGGGGACGAAGCAGAGCAGGAAAAGCGCCTGAAAGATTTTGGT
TCTTTCCAGGTCAACACCGAACTCCTCGGAGTCGCAAAACCGGATGTAATAGTAATGCACTGCCTTCCTGCCAGGAGAGG
CCTTGAAATCACGGACGAAGTTATGGACGGCCCAAACTCCGTGATCTTCGAAGAGGCAGAAAACCGCCTTCACGCGCAGA
AAGCCCTTATCCTGAAATTGATGAGATAA

Upstream 100 bases:

>100_bases
GCCTGGAAACAAAACAGAGCCTGGAAATAAAGCCCAGATTTAAAGTTTGGTTTCAGCCAGAAGTTTAAACTCAGCCGTAA
AGAAGTCGGGATTTGAGACG

Downstream 100 bases:

>100_bases
AATTTCATCAATTTCTCCTCTATATTTCTCCTCTATGATTGAGAGGACTCATATGAAATAAATATATATTAGAAGTTATC
GGGTTTTTTCACCTTCCGAG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKRDVLSITDLSREEIYELLESAADLKKKRKAGEPTEYLKHKSLGMIFEKSSTRTRVSFEVAMSDFGGHALYLNSRDIQV
GRGETIEDTARTLSGYLHGIMARVMSHDTVEKLARFSTIPVINALSDREHPCQILGDFMTIMEYKNRFEGLKFAWIGDGN
NVCNSALLGSAIMGMEFVIACPEGYEPGAEFLEKAKALGGKFSITDDPKTAAKDADIIYTDVWVSMGDEAEQEKRLKDFG
SFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKLMR

Sequences:

>Translated_302_residues
MKRDVLSITDLSREEIYELLESAADLKKKRKAGEPTEYLKHKSLGMIFEKSSTRTRVSFEVAMSDFGGHALYLNSRDIQV
GRGETIEDTARTLSGYLHGIMARVMSHDTVEKLARFSTIPVINALSDREHPCQILGDFMTIMEYKNRFEGLKFAWIGDGN
NVCNSALLGSAIMGMEFVIACPEGYEPGAEFLEKAKALGGKFSITDDPKTAAKDADIIYTDVWVSMGDEAEQEKRLKDFG
SFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKLMR
>Mature_302_residues
MKRDVLSITDLSREEIYELLESAADLKKKRKAGEPTEYLKHKSLGMIFEKSSTRTRVSFEVAMSDFGGHALYLNSRDIQV
GRGETIEDTARTLSGYLHGIMARVMSHDTVEKLARFSTIPVINALSDREHPCQILGDFMTIMEYKNRFEGLKFAWIGDGN
NVCNSALLGSAIMGMEFVIACPEGYEPGAEFLEKAKALGGKFSITDDPKTAAKDADIIYTDVWVSMGDEAEQEKRLKDFG
SFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKLMR

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=304, Percent_Identity=42.4342105263158, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI18105007, Length=306, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786469, Length=324, Percent_Identity=36.4197530864198, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790703, Length=323, Percent_Identity=35.9133126934984, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI2367364, Length=308, Percent_Identity=31.4935064935065, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=326, Percent_Identity=27.6073619631902, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322373, Length=314, Percent_Identity=37.8980891719745, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322331, Length=306, Percent_Identity=30.718954248366, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24642586, Length=304, Percent_Identity=28.9473684210526, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 33707; Mature: 33707

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDVLSITDLSREEIYELLESAADLKKKRKAGEPTEYLKHKSLGMIFEKSSTRTRVSFE
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEEEE
VAMSDFGGHALYLNSRDIQVGRGETIEDTARTLSGYLHGIMARVMSHDTVEKLARFSTIP
EEECCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VINALSDREHPCQILGDFMTIMEYKNRFEGLKFAWIGDGNNVCNSALLGSAIMGMEFVIA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEE
CPEGYEPGAEFLEKAKALGGKFSITDDPKTAAKDADIIYTDVWVSMGDEAEQEKRLKDFG
CCCCCCHHHHHHHHHHHCCCCEEECCCCCHHCCCCCEEEEEEEEECCCHHHHHHHHHHCC
SFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKL
CEEECCEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHH
MR
CC
>Mature Secondary Structure
MKRDVLSITDLSREEIYELLESAADLKKKRKAGEPTEYLKHKSLGMIFEKSSTRTRVSFE
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEEEE
VAMSDFGGHALYLNSRDIQVGRGETIEDTARTLSGYLHGIMARVMSHDTVEKLARFSTIP
EEECCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VINALSDREHPCQILGDFMTIMEYKNRFEGLKFAWIGDGNNVCNSALLGSAIMGMEFVIA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEE
CPEGYEPGAEFLEKAKALGGKFSITDDPKTAAKDADIIYTDVWVSMGDEAEQEKRLKDFG
CCCCCCHHHHHHHHHHHCCCCEEECCCCCHHCCCCCEEEEEEEEECCCHHHHHHHHHHCC
SFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKL
CEEECCEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHH
MR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]