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The map label for this gene is DeoA [H]

Identifier: 20806972

GI number: 20806972

Start: 477269

End: 478564

Strand: Direct

Name: DeoA [H]

Synonym: TTE0464

Alternate gene names: 20806972

Gene position: 477269-478564 (Clockwise)

Preceding gene: 20806971

Following gene: 20806973

Centisome position: 17.75

GC content: 40.05

Gene sequence:

>1296_bases
ATGAGAATGTATGACCTTATACTAAAAAAGAGGGATGGCGGTATACTCACCAAAGAGGAAATAGATTTTATAATCTCAGG
CTACACAAAAGACTACATTCCTGATTACCAGATAAGCGCTCTTTTAATGGCCATATATTTTAGAGGAATGACTCCTGAGG
AGACTTCTCACCTTACAATGGCAATGGCTTACTCTGGCGATGTACTTGATTTATCTAGAATAAAAGGAATAAAAGTGGAT
AAACATTCAACTGGTGGAGTGGCGGATACTACTACATTAGTGCTTGCTCCTATGGTAGCTGCTTGCGGAGCGCCTGTTGC
CAAGATGTCGGGAAGAGGTTTAGGGCATACTGGAGGAACGATAGATAAACTGGAATCCATACCTGGAATGAGAGTAGAGC
TTTCTGAAGAGGAATTTATTGATAATGTGAATAAATACGGAATTGCAATTATCGGTCAGACAAAAAATTTGACTCCTGCC
GACAAAAAATTGTACGCTTTAAGAGATGTTACTGCAACTGTAGATTCTATTCCTCTTATAGCAAGTTCTATCATGAGTAA
AAAAATTGCGGCAGGAGCTGACGGAATAGTATTGGACGTAAAAGTTGGAAGAGGCGCTTTCATGAAGGATTTGGAAAGCG
CAAAAAAACTCGCAAAATTAATGGTGGACATTGGGAATTCTGTTGGAAGAAAGACAGTAGCTCATGTGACCAATATGGAT
TATCCTCTAGGGCTTGCAATAGGAAATGCTCTTGAGGTTTTAGAAGCGATACAGGTATTAAAAGGGCATGGGTCAAAAGA
CCTCCTGGAGGTTTGCATGTTATTAGGTTCAGATATGCTGCAGATTGCAGGTATTGCCAAAGATGATAATGAGGCAAGAG
CCAAATTAAAAGACGCTTTAGAGAGTGGCAAAGCACTTCAGAAATTCAAGGAGTTCATAAGAGCACAGGGAGGAGACGAC
AGAGTAGTAGATGATCCAACCCTTTTGCCTCAGGCTAAATATGTAAGGCCGTGGATTGCTGACAGGGATGTGTATATAAA
GGATTTAATGGCACTAGATTTAGGGCTTTTGGCAATGAAGTTGGGAGCAGGCAGGGAAAGAAAAGAAGATAAAATTGATT
TGGCAGTTGGAATAATGCTGGGTGGAAAGGTAGGAGAAGTAATAAAGAAAGGTGAACCCATTGCTACTATATATGCTAAT
GATGAAAGCAAAGCTGACTGGGCATTTGAAGAGATTAAGAAATACATCCTGCTTTCAGATGAACCAGTGGAAAGGCCTGT
TTTAATATACGAATAA

Upstream 100 bases:

>100_bases
TGATGTGGCAGCTACAATTGCTGAAATTTTCAACGTGGGTCCTATACACACAGGCACTTCTTTTTTAAGGGAATTACCTT
TGAAAGTGGGGGTATAATTT

Downstream 100 bases:

>100_bases
GCTGAGGGGGTTTTACACCCCTTTTTTTATTAAAATTTTTTCAATTTAAACCGATAAATAAATAGGAACTTTTTACAAAA
ATTTAGATGAAGGGGAGACG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRMYDLILKKRDGGILTKEEIDFIISGYTKDYIPDYQISALLMAIYFRGMTPEETSHLTMAMAYSGDVLDLSRIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRVELSEEEFIDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSIMSKKIAAGADGIVLDVKVGRGAFMKDLESAKKLAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEVLEAIQVLKGHGSKDLLEVCMLLGSDMLQIAGIAKDDNEARAKLKDALESGKALQKFKEFIRAQGGDD
RVVDDPTLLPQAKYVRPWIADRDVYIKDLMALDLGLLAMKLGAGRERKEDKIDLAVGIMLGGKVGEVIKKGEPIATIYAN
DESKADWAFEEIKKYILLSDEPVERPVLIYE

Sequences:

>Translated_431_residues
MRMYDLILKKRDGGILTKEEIDFIISGYTKDYIPDYQISALLMAIYFRGMTPEETSHLTMAMAYSGDVLDLSRIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRVELSEEEFIDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSIMSKKIAAGADGIVLDVKVGRGAFMKDLESAKKLAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEVLEAIQVLKGHGSKDLLEVCMLLGSDMLQIAGIAKDDNEARAKLKDALESGKALQKFKEFIRAQGGDD
RVVDDPTLLPQAKYVRPWIADRDVYIKDLMALDLGLLAMKLGAGRERKEDKIDLAVGIMLGGKVGEVIKKGEPIATIYAN
DESKADWAFEEIKKYILLSDEPVERPVLIYE
>Mature_431_residues
MRMYDLILKKRDGGILTKEEIDFIISGYTKDYIPDYQISALLMAIYFRGMTPEETSHLTMAMAYSGDVLDLSRIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRVELSEEEFIDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSIMSKKIAAGADGIVLDVKVGRGAFMKDLESAKKLAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEVLEAIQVLKGHGSKDLLEVCMLLGSDMLQIAGIAKDDNEARAKLKDALESGKALQKFKEFIRAQGGDD
RVVDDPTLLPQAKYVRPWIADRDVYIKDLMALDLGLLAMKLGAGRERKEDKIDLAVGIMLGGKVGEVIKKGEPIATIYAN
DESKADWAFEEIKKYILLSDEPVERPVLIYE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=441, Percent_Identity=40.8163265306122, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI4503445, Length=441, Percent_Identity=40.8163265306122, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI166158922, Length=441, Percent_Identity=40.8163265306122, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1790842, Length=407, Percent_Identity=45.945945945946, Blast_Score=335, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46836; Mature: 46836

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLILKKRDGGILTKEEIDFIISGYTKDYIPDYQISALLMAIYFRGMTPEETSHLTM
CCHHHHHHEECCCCCEEHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
AMAYSGDVLDLSRIKGIKVDKHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGT
EEEECCCEEEHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIPGMRVELSEEEFIDNVNKYGIAIIGQTKNLTPADKKLYALRDVTATVDSIPLI
HHHHHCCCCCEEEECHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADGIVLDVKVGRGAFMKDLESAKKLAKLMVDIGNSVGRKTVAHVTNMD
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
YPLGLAIGNALEVLEAIQVLKGHGSKDLLEVCMLLGSDMLQIAGIAKDDNEARAKLKDAL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
ESGKALQKFKEFIRAQGGDDRVVDDPTLLPQAKYVRPWIADRDVYIKDLMALDLGLLAMK
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LGAGRERKEDKIDLAVGIMLGGKVGEVIKKGEPIATIYANDESKADWAFEEIKKYILLSD
HCCCCCCCCCCCEEEEEEEECCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHEEECC
EPVERPVLIYE
CCCCCCEEEEC
>Mature Secondary Structure
MRMYDLILKKRDGGILTKEEIDFIISGYTKDYIPDYQISALLMAIYFRGMTPEETSHLTM
CCHHHHHHEECCCCCEEHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
AMAYSGDVLDLSRIKGIKVDKHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGT
EEEECCCEEEHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIPGMRVELSEEEFIDNVNKYGIAIIGQTKNLTPADKKLYALRDVTATVDSIPLI
HHHHHCCCCCEEEECHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADGIVLDVKVGRGAFMKDLESAKKLAKLMVDIGNSVGRKTVAHVTNMD
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
YPLGLAIGNALEVLEAIQVLKGHGSKDLLEVCMLLGSDMLQIAGIAKDDNEARAKLKDAL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
ESGKALQKFKEFIRAQGGDDRVVDDPTLLPQAKYVRPWIADRDVYIKDLMALDLGLLAMK
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LGAGRERKEDKIDLAVGIMLGGKVGEVIKKGEPIATIYANDESKADWAFEEIKKYILLSD
HCCCCCCCCCCCEEEEEEEECCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHEEECC
EPVERPVLIYE
CCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]