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The map label for this gene is 20094491

Identifier: 20094491

GI number: 20094491

Start: 1022751

End: 1023809

Strand: Direct

Name: 20094491

Synonym: MK1055

Alternate gene names: NA

Gene position: 1022751-1023809 (Clockwise)

Preceding gene: 20094489

Following gene: 20094493

Centisome position: 60.34

GC content: 64.59

Gene sequence:

>1059_bases
CTGGCTTTAGTATACCATGAGGAGTACCTCCGACACGAACAGCACCCCACGCATCCGGAACGTCGTGAGCGTCTCTCCTA
CACGGTGGACAGGTTCGAAGAGGAGGGGTTGTTCGAGATCGAGGGGATCGATCTAGTTGAGCCCGACCCCGTCGACCGCG
AGGTGATCGAACTCGTACATGATCCCGAACACGTGGAGCTGATCCGGCGGATGAGCGAGTCGGGCGGTGGTATGATCGAC
CTGGACACCGCCGTCGCTCCGGAGACCTACGATCAGGCCCTGCTAGCGGCCGGAGGCTCCGTTCTCGCCGTCGAGCTGGT
CGTGCGGGGAGAGTACGACACGGCTTTCGCGATGGTTCGACCGCCGGGCCACCATGCCGGTCGCGCCAAGGCTGCCGGCT
TCTGCTACTTCAATAACGCGGCGATCGCCGCCGAGTATGCGATCCGCGAGCTGGGCGTGGATTCCGTCGCCATCCTGGAC
TGGGACGCCCACCACGGTGACGGGACTCAGGAGATCTTCTACGACCGTGACGACGTGCTCTACGTCTCGATACACCAGGA
CGGGCGCACCCTGTATCCCGGCACGGGCTTCCCGTACGAGGCGGGTGAGGGGCCAGGTGAAGGGTACACCGTGAACATCC
CCGTGCTCCCGCGTTCCGGTGATCGGACGTACCGTGAAGCCTTCCAGCGGATCGTGGAGCCTGTGGTGCGGGAATTCGAC
CCCGATCTGATCCTGATCTCCGCGGGTCAGGACTGCCACTTCACGGACCCAATCACGGATCTCGCGGTCACGGCTGAGGG
ATACCGGTGGATGATGCAACGGGCGACCGAGCTCGCGGAGGACCTGGGAGCTTCGGGACCCGTCGCCGTGCTGGAGGGGG
GTTATTCCGTCGAGGACGGGCTCCCGTACACCAACCTGGGCGTCGTATGTGGTATGGCGGGGGTTCCGGCCGATCTGCGG
GAGCCCATGGATCCACAGGAGGAGAATCCGCGGGGGCCGGAGGGGGTTCGAAAGGTGGCCCGTGAGCACTCCCGGTACTG
GACCTCTGTGAAGGCGTGA

Upstream 100 bases:

>100_bases
TCGATCATCCCTCCGGCCGGTCTCCCCCGCCCGCTCCTCACAGCTCCGAGATCATCCGAGCGTCGGGTGGTGATACACCT
TGTGGGAGGCCGAGAGGACG

Downstream 100 bases:

>100_bases
GACCTTCGGGTGACGTCGAGGGCTTATACCTGGCGGTATGACGTATCGAGCGGGGCTCAGCTGCAACCGGTAATGTCCGG
CAGTTCGTGATCTCACGCGG

Product: deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MALVYHEEYLRHEQHPTHPERRERLSYTVDRFEEEGLFEIEGIDLVEPDPVDREVIELVHDPEHVELIRRMSESGGGMID
LDTAVAPETYDQALLAAGGSVLAVELVVRGEYDTAFAMVRPPGHHAGRAKAAGFCYFNNAAIAAEYAIRELGVDSVAILD
WDAHHGDGTQEIFYDRDDVLYVSIHQDGRTLYPGTGFPYEAGEGPGEGYTVNIPVLPRSGDRTYREAFQRIVEPVVREFD
PDLILISAGQDCHFTDPITDLAVTAEGYRWMMQRATELAEDLGASGPVAVLEGGYSVEDGLPYTNLGVVCGMAGVPADLR
EPMDPQEENPRGPEGVRKVAREHSRYWTSVKA

Sequences:

>Translated_352_residues
MALVYHEEYLRHEQHPTHPERRERLSYTVDRFEEEGLFEIEGIDLVEPDPVDREVIELVHDPEHVELIRRMSESGGGMID
LDTAVAPETYDQALLAAGGSVLAVELVVRGEYDTAFAMVRPPGHHAGRAKAAGFCYFNNAAIAAEYAIRELGVDSVAILD
WDAHHGDGTQEIFYDRDDVLYVSIHQDGRTLYPGTGFPYEAGEGPGEGYTVNIPVLPRSGDRTYREAFQRIVEPVVREFD
PDLILISAGQDCHFTDPITDLAVTAEGYRWMMQRATELAEDLGASGPVAVLEGGYSVEDGLPYTNLGVVCGMAGVPADLR
EPMDPQEENPRGPEGVRKVAREHSRYWTSVKA
>Mature_351_residues
ALVYHEEYLRHEQHPTHPERRERLSYTVDRFEEEGLFEIEGIDLVEPDPVDREVIELVHDPEHVELIRRMSESGGGMIDL
DTAVAPETYDQALLAAGGSVLAVELVVRGEYDTAFAMVRPPGHHAGRAKAAGFCYFNNAAIAAEYAIRELGVDSVAILDW
DAHHGDGTQEIFYDRDDVLYVSIHQDGRTLYPGTGFPYEAGEGPGEGYTVNIPVLPRSGDRTYREAFQRIVEPVVREFDP
DLILISAGQDCHFTDPITDLAVTAEGYRWMMQRATELAEDLGASGPVAVLEGGYSVEDGLPYTNLGVVCGMAGVPADLRE
PMDPQEENPRGPEGVRKVAREHSRYWTSVKA

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=370, Percent_Identity=35.9459459459459, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI30795204, Length=386, Percent_Identity=32.3834196891192, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI30795202, Length=386, Percent_Identity=32.3834196891192, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI17158039, Length=331, Percent_Identity=34.7432024169184, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI169234807, Length=394, Percent_Identity=32.741116751269, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI153085395, Length=394, Percent_Identity=32.741116751269, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI148539870, Length=394, Percent_Identity=32.741116751269, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI13128864, Length=365, Percent_Identity=32.8767123287671, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI62750349, Length=390, Percent_Identity=32.0512820512821, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI62750347, Length=390, Percent_Identity=32.0512820512821, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI226529806, Length=370, Percent_Identity=33.5135135135135, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI13128860, Length=296, Percent_Identity=28.0405405405405, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI293336691, Length=264, Percent_Identity=29.9242424242424, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13128862, Length=292, Percent_Identity=26.7123287671233, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI8923769, Length=231, Percent_Identity=25.1082251082251, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI262073088, Length=144, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI262073092, Length=198, Percent_Identity=25.7575757575758, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540334, Length=364, Percent_Identity=33.7912087912088, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17540332, Length=364, Percent_Identity=33.7912087912088, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI193206283, Length=364, Percent_Identity=33.7912087912088, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI193209491, Length=382, Percent_Identity=31.6753926701571, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25154020, Length=303, Percent_Identity=31.3531353135314, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25154022, Length=305, Percent_Identity=30.8196721311475, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17534739, Length=307, Percent_Identity=27.3615635179153, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=311, Percent_Identity=31.1897106109325, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508561, Length=260, Percent_Identity=28.0769230769231, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17561978, Length=270, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324307, Length=360, Percent_Identity=36.9444444444444, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6323999, Length=288, Percent_Identity=26.3888888888889, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321244, Length=246, Percent_Identity=28.8617886178862, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325325, Length=145, Percent_Identity=28.9655172413793, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6325141, Length=64, Percent_Identity=50, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642146, Length=298, Percent_Identity=38.5906040268456, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24642142, Length=298, Percent_Identity=38.5906040268456, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24642144, Length=298, Percent_Identity=38.5906040268456, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281360899, Length=294, Percent_Identity=38.7755102040816, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24641720, Length=358, Percent_Identity=33.5195530726257, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281360799, Length=358, Percent_Identity=33.5195530726257, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281360801, Length=358, Percent_Identity=33.5195530726257, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24657891, Length=264, Percent_Identity=30.3030303030303, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644244, Length=173, Percent_Identity=33.5260115606936, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39013; Mature: 38882

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVYHEEYLRHEQHPTHPERRERLSYTVDRFEEEGLFEIEGIDLVEPDPVDREVIELVH
CEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHC
DPEHVELIRRMSESGGGMIDLDTAVAPETYDQALLAAGGSVLAVELVVRGEYDTAFAMVR
CCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEC
PPGHHAGRAKAAGFCYFNNAAIAAEYAIRELGVDSVAILDWDAHHGDGTQEIFYDRDDVL
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHEEECCCCEE
YVSIHQDGRTLYPGTGFPYEAGEGPGEGYTVNIPVLPRSGDRTYREAFQRIVEPVVREFD
EEEEECCCCEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
PDLILISAGQDCHFTDPITDLAVTAEGYRWMMQRATELAEDLGASGPVAVLEGGYSVEDG
CCEEEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCC
LPYTNLGVVCGMAGVPADLREPMDPQEENPRGPEGVRKVAREHSRYWTSVKA
CCCCCHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALVYHEEYLRHEQHPTHPERRERLSYTVDRFEEEGLFEIEGIDLVEPDPVDREVIELVH
EEEECHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHC
DPEHVELIRRMSESGGGMIDLDTAVAPETYDQALLAAGGSVLAVELVVRGEYDTAFAMVR
CCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEC
PPGHHAGRAKAAGFCYFNNAAIAAEYAIRELGVDSVAILDWDAHHGDGTQEIFYDRDDVL
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHEEECCCCEE
YVSIHQDGRTLYPGTGFPYEAGEGPGEGYTVNIPVLPRSGDRTYREAFQRIVEPVVREFD
EEEEECCCCEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
PDLILISAGQDCHFTDPITDLAVTAEGYRWMMQRATELAEDLGASGPVAVLEGGYSVEDG
CCEEEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCC
LPYTNLGVVCGMAGVPADLREPMDPQEENPRGPEGVRKVAREHSRYWTSVKA
CCCCCHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]