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The map label for this gene is rio2 [H]

Identifier: 20094436

GI number: 20094436

Start: 960189

End: 961070

Strand: Direct

Name: rio2 [H]

Synonym: MK1000

Alternate gene names: 20094436

Gene position: 960189-961070 (Clockwise)

Preceding gene: 20094434

Following gene: 20094437

Centisome position: 56.65

GC content: 60.09

Gene sequence:

>882_bases
ATGGTGATGGTGGAGAGGGTGGTACAGGCCCTTCCGGAGATGGAACCCGAGGATTTCAAGGTCCTACGAGCCCTCGAGCT
GGAGATGCGCAGGCACGATTGGGTCCCGTTCGATCGACTGCTCGAACGCACCGGTCTCGACGAGAAGGAGCTAGGCTACC
GTCTGTCCAGACTCGATCGTTGGGATATGGTCGTCCGAACGCGACGGCAAACGGTCGGGTATCTAGGTTACCAACTGCGT
CCCGAAGGGTACGACGCCCTCGCCCTCCGGGCGCTCGTGGACCAAGGCGTGTTGGAAGGACTCGGCCCGGAGATCGGGGT
GGGAAAAGAAGCTGACGTGTACTTGGGCATCTCCCCCAAGGGCGCGCAGCTGGCCGTCAAGTTCAATCGAATCGGTCGTA
CCAGTTACACTAAGATCAAACGGTACCGTGAGTACGTGAAGGATAAGCGTCACATCTCGTGGCTTTACGTTAATAGACTC
ACGGCCGAGCGTGAGTTCGAGGCGCTTTTACACCTGTACCCTGAGGGCGTTTCCGTCCCCAGGCCCGTCGCTCAGAACAG
ACACGTACTCGTGATGGAACGCTTCGAGGGACGGGAACTCGCGGAAACTCGGGTGGAAAACCCCGAGGCGGTCTTGAACC
GGGTGCTCGAGGAGTACGAACACGCCCTCGAGGTCGGCGTGGTTCACGGGGACCTGAGTCAGTTCAACATAGTCGTCGAG
GGCGACGACGTGCTGCTCATCGACTGGGCGCACTGGGTCGAGGTATCCCACCCCTCGGCCCGTGAGCTCGTCGAACGCGA
CGTACGGAACGTATGCGACTACTTCCGCCGGAAATACGGCGTTCACAGGCATCCGCGGGAGTTCTTCGAGAATTCCGGAT
GA

Upstream 100 bases:

>100_bases
TTCCTGGATTTGGGGACGGGTCGAGTCACGTTCACCACCCCTACTGACGGGTGTTCGCCCCTTTAGGAATTACCCGTTTT
CGCTGCGGAGGTAGCCAGAC

Downstream 100 bases:

>100_bases
GGAGGCTTACGGGGATCGAGGCGCGCCGATGAGAGGGTGGCCCGTTACCGACGGGCCATTACACGTCGCGATGGGGGATA
ACGTTCCCCGATGAATTCGA

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MVMVERVVQALPEMEPEDFKVLRALELEMRRHDWVPFDRLLERTGLDEKELGYRLSRLDRWDMVVRTRRQTVGYLGYQLR
PEGYDALALRALVDQGVLEGLGPEIGVGKEADVYLGISPKGAQLAVKFNRIGRTSYTKIKRYREYVKDKRHISWLYVNRL
TAEREFEALLHLYPEGVSVPRPVAQNRHVLVMERFEGRELAETRVENPEAVLNRVLEEYEHALEVGVVHGDLSQFNIVVE
GDDVLLIDWAHWVEVSHPSARELVERDVRNVCDYFRRKYGVHRHPREFFENSG

Sequences:

>Translated_293_residues
MVMVERVVQALPEMEPEDFKVLRALELEMRRHDWVPFDRLLERTGLDEKELGYRLSRLDRWDMVVRTRRQTVGYLGYQLR
PEGYDALALRALVDQGVLEGLGPEIGVGKEADVYLGISPKGAQLAVKFNRIGRTSYTKIKRYREYVKDKRHISWLYVNRL
TAEREFEALLHLYPEGVSVPRPVAQNRHVLVMERFEGRELAETRVENPEAVLNRVLEEYEHALEVGVVHGDLSQFNIVVE
GDDVLLIDWAHWVEVSHPSARELVERDVRNVCDYFRRKYGVHRHPREFFENSG
>Mature_293_residues
MVMVERVVQALPEMEPEDFKVLRALELEMRRHDWVPFDRLLERTGLDEKELGYRLSRLDRWDMVVRTRRQTVGYLGYQLR
PEGYDALALRALVDQGVLEGLGPEIGVGKEADVYLGISPKGAQLAVKFNRIGRTSYTKIKRYREYVKDKRHISWLYVNRL
TAEREFEALLHLYPEGVSVPRPVAQNRHVLVMERFEGRELAETRVENPEAVLNRVLEEYEHALEVGVVHGDLSQFNIVVE
GDDVLLIDWAHWVEVSHPSARELVERDVRNVCDYFRRKYGVHRHPREFFENSG

Specific function: Unknown

COG id: COG0478

COG function: function code T; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI229331971, Length=275, Percent_Identity=36, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI229331967, Length=275, Percent_Identity=36, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI23510356, Length=219, Percent_Identity=27.8538812785388, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI22325377, Length=217, Percent_Identity=26.2672811059908, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510358, Length=137, Percent_Identity=30.6569343065693, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564178, Length=274, Percent_Identity=37.2262773722628, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556977, Length=207, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532073, Length=206, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324122, Length=275, Percent_Identity=29.4545454545455, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324693, Length=233, Percent_Identity=24.8927038626609, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24649986, Length=276, Percent_Identity=32.9710144927536, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24662811, Length=221, Percent_Identity=28.5067873303167, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356879, Length=221, Percent_Identity=28.5067873303167, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR015285
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1; PF09202 Rio2_N [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 34321; Mature: 34321

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMVERVVQALPEMEPEDFKVLRALELEMRRHDWVPFDRLLERTGLDEKELGYRLSRLDR
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
WDMVVRTRRQTVGYLGYQLRPEGYDALALRALVDQGVLEGLGPEIGVGKEADVYLGISPK
HHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
GAQLAVKFNRIGRTSYTKIKRYREYVKDKRHISWLYVNRLTAEREFEALLHLYPEGVSVP
CCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHCCCCCCCC
RPVAQNRHVLVMERFEGRELAETRVENPEAVLNRVLEEYEHALEVGVVHGDLSQFNIVVE
CCCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEE
GDDVLLIDWAHWVEVSHPSARELVERDVRNVCDYFRRKYGVHRHPREFFENSG
CCCEEEEEHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
>Mature Secondary Structure
MVMVERVVQALPEMEPEDFKVLRALELEMRRHDWVPFDRLLERTGLDEKELGYRLSRLDR
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
WDMVVRTRRQTVGYLGYQLRPEGYDALALRALVDQGVLEGLGPEIGVGKEADVYLGISPK
HHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
GAQLAVKFNRIGRTSYTKIKRYREYVKDKRHISWLYVNRLTAEREFEALLHLYPEGVSVP
CCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHCCCCCCCC
RPVAQNRHVLVMERFEGRELAETRVENPEAVLNRVLEEYEHALEVGVVHGDLSQFNIVVE
CCCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEE
GDDVLLIDWAHWVEVSHPSARELVERDVRNVCDYFRRKYGVHRHPREFFENSG
CCCEEEEEHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]