Click here to switch to the map view.

The map label for this gene is GCD7

Identifier: 20094403

GI number: 20094403

Start: 927666

End: 928082

Strand: Direct

Name: GCD7

Synonym: MK0967

Alternate gene names: 20094403

Gene position: 927666-928082 (Clockwise)

Preceding gene: 20094402

Following gene: 20094404

Centisome position: 54.73

GC content: 58.51

Gene sequence:

>417_bases
GTGGTCGAGTACGACTACGAGGAACTCCTCGAGCGCGCTTACGAGCAGCTTCCCGAGGAGGTGCTCGAAGATCGCCGGTT
CGAGATGCCCAAGCCGAAGGTCTCCGTGGAGGGTAAGACCACGGTCATCCGCAACTTCAAGGAGATCTCCAAGAAGCTCG
ACCGCGATCCCGAGCACATCACCAAGTACTTCCTGAAGGAGCTCGGTACCGCGGGACACGTCGACGGTGGTAGACTCATC
CTGCACGGGGTTTACCATCCTAAGCTCGTCGAGGAGGAGCTTAAGAACTACGTCGAGGAATTCGTGCTATGCCCGGAGTG
CGGGAAACCCGACACCAAGCTCGTCAGAGAGGATCGGCAGTGGATTCTCAAATGCGAAGCTTGCGGTGCCTGGTCCTCGG
TTCGGAGGCTGAAGTGA

Upstream 100 bases:

>100_bases
GATCATTAAAGAGATGGAGGAGCGCGAGCTCCTGTACCCGATGGATCTGCCCGGAGGGAAACGTTGGTCCGTGATAGAAA
CCGGCTGGGGGTTGTAAACC

Downstream 100 bases:

>100_bases
ATGGCTCGGGTGCTCTTGAACATCCACGGGACCGGAGACACCGTGGTCCTCGCCCTATGCGACGAGGATCTCCTGGGTGT
GGAGTTGAAGTACAAAGGGC

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHITKYFLKELGTAGHVDGGRLI
LHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQWILKCEACGAWSSVRRLK

Sequences:

>Translated_138_residues
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHITKYFLKELGTAGHVDGGRLI
LHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQWILKCEACGAWSSVRRLK
>Mature_138_residues
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHITKYFLKELGTAGHVDGGRLI
LHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQWILKCEACGAWSSVRRLK

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family

Homologues:

Organism=Homo sapiens, GI29826335, Length=143, Percent_Identity=39.8601398601399, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI37537716, Length=112, Percent_Identity=39.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI21361337, Length=112, Percent_Identity=39.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508049, Length=142, Percent_Identity=34.5070422535211, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25146154, Length=110, Percent_Identity=39.0909090909091, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32566626, Length=110, Percent_Identity=39.0909090909091, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25146151, Length=110, Percent_Identity=39.0909090909091, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325018, Length=142, Percent_Identity=38.0281690140845, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325298, Length=111, Percent_Identity=35.1351351351351, Blast_Score=74, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17647377, Length=143, Percent_Identity=38.4615384615385, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45555633, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45555623, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18860089, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45555642, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642373, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45555665, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45555652, Length=112, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2B_METKA (Q8TWR5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614250.1
- ProteinModelPortal:   Q8TWR5
- SMR:   Q8TWR5
- GeneID:   1477068
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0967
- NMPDR:   fig|190192.1.peg.963
- HOGENOM:   HBG738095
- OMA:   FLKCEAC
- ProtClustDB:   PRK03988
- BioCyc:   MKAN190192:MK0967-MONOMER
- HAMAP:   MF_00232
- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190
- SMART:   SM00653
- TIGRFAMs:   TIGR00311

Pfam domain/function: PF01873 eIF-5_eIF-2B; SSF100966 Transl_init_fac_IF2/IF5_N; SSF75689 Transl_init_fac_IF2/IF5_Zn-bd

EC number: NA

Molecular weight: Translated: 16267; Mature: 16267

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHH
TKYFLKELGTAGHVDGGRLILHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQ
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
WILKCEACGAWSSVRRLK
HHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHH
TKYFLKELGTAGHVDGGRLILHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQ
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
WILKCEACGAWSSVRRLK
HHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014