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The map label for this gene is MCM2_1 [H]

Identifier: 20094401

GI number: 20094401

Start: 925021

End: 926991

Strand: Direct

Name: MCM2_1 [H]

Synonym: MK0965

Alternate gene names: 20094401

Gene position: 925021-926991 (Clockwise)

Preceding gene: 20094400

Following gene: 20094402

Centisome position: 54.57

GC content: 63.12

Gene sequence:

>1971_bases
GTGGAGATGGAGCGTGAGTTCGAAGAGGCTCTCAGGAACTCGAAAACGTTCCTGAGGTCGATCGACCGGGTGATCACGGA
CTACCCGAAGTGGCGAACCGTCGTCGTGGACTTGGAGGAGTTCGACGAACCGGACATAGCGTTCGCGGTGTCCGACGACG
TCGTCGAGGCGATGAAGGTCGTCCAGCGGGTTGCCATGGAGCTCATCAAGAAAGAGCGGCCGGACGTGGATCGTGTCTGG
GTAGAGTTCCGTGGGTCACCGATCCGTCTCCGTGCCCGGGATATGAGCGTCGAGTTCAAGGATCGTCTCGTCACCGTCGA
GGGGATCGTTCGTCGCGTGGATAACGTGGCCGCCGAGGTAGTTCGCGTGGAAGCCGAGTGTCCGCAGTGCGGTAATCGGT
TCGAGGTCCGTAGGCGCGAGTACAGACCTGACGTGAGGTGTCCCAACTGCGGGATGCGGTGCGAGCCCGACGAGCTCTTC
TACACCGACTATCAGCTCGTAGTGCTCCAAGAAGCTCCAGAGCACGTGAGAGGCGGTGAACAACCGGCGACAGTCGAGGT
GGAGTTCCGGTACGATCACATCAACCGGGTACGGCCCGGTGACCGGGTGAGGGTTACGGCGGTACCTCGGGTACGACTTC
CGTCGAGTTCTCCACGACCGGGTGATACCGGGGAGATAGTCCTCGAGGCCCACGGTGTCGAGAGGTCCGACAGCCCGCTT
CCCGAGGAGGACCTCCGGTTCACGCAGGATGAGGTCGAACGGTTCGAGGAACTGGCCGAGGGTGATCCATTAGGTGAGTT
CGTCGAAGCGGTGGCGCCCCACATTCACGGGCACGAGGTGATCAAGAAGGCCGTGTCGTTACAGCTGTTCTCCTGCGTGG
AGGAGGGTCAGATACGGGAGCGTGTTCACGTTCTCATCGTAGGTGATCCGGCGACGGCGAAGTCCCAGATCCTCCAGCAC
GTGATCGAGCACCTCGCCCCCCGCGGCGTGTACGTGAGCGCCCAACACGTGACGGGGGCCGGACTCACCGCGGCCGCCGA
ACGTACGGAGGACGGGTGGACGCTGGAAGCGGGAGCCGTGGTCATGGCGGACGGCGGCGTGATAGCCATCGACGAGCTGG
ACAAGGCGTCCAGGGGCGATCTGAACGCGCTCCTCGAGGCGATGGAGTCGGGTAAGATCAGCGTCGCGAAGGCCGGTATC
ACGACGACCCTGAACGCCCGATGCGCGGTCCTGGCGGCCGCCAACCCCGAGGCCGGCCGCTGGCAGGGCGGTCACCCCAT
CGAGGAGATCAACCTGGACCCCGCCCTCCTCTCGAGGTTCGACGTCATCCTGTTCACCCGAGACGAGCCGGATCCGGAGC
AGGATAAGCTGGTCGCGGAACGGATGATGGAGGCTTTCGACGGCGAGTTCGATGAGATCGAGGGTAAGTACGAGCTGTTA
CGCCGCTACGTCCTGTACGCTACGAAGGAGTTTCCGAACGTCACCATCTCCGAAGACGCCCGGGAGGAGCTTCGAGACTG
GTTCGTGTCCGCCCGACAGGAGGCGGCTGATCGGATCGACGAGGGAGATCTACGCACCGTGCCGGTCACACGGCGTCAGA
TGGGCTCCGTTCTGCGACTAGCCCGAGCTTCCGCCCGTATGCGACTCTCTGAGACAGTCGGTCGAGGGGACGTGTCCGTA
GCTCTGTCGGTAGTAGAAGAGTTCATGAAGGAGGTAATGCAGGAGGACGGCGTACTGGACGCGGACGTGATCGAGACGGG
TAAACCCAAGTCGGTGCGAGAGGTCCGTGAGTACGTGCTGAAGGTGGTGCGGAAGCTGGCGAAGAAGCACGAGGACGGTG
TACCCAAGCGGGAGATCGTGAAGGCGGTTAAACACCGCGTGAGCCGTGAGCGGGTCGAGGAGATCCTGGACGACCTCGTC
GAGGAGGGCTCCCTTCTCCAGCCGCGGCCCGGAGTGTACCTCCCGATGTGA

Upstream 100 bases:

>100_bases
CTGTCGGTAGGCTGTGCACTGACGGCCAGCGGGGTACTAGGGGTCCTCCGGTGGATGACCTCCGTTCCGGCGGTGCCGTG
GTGACGGGGGCGGGAATTCC

Downstream 100 bases:

>100_bases
ACGGGTGGTTGAACATGAGTGAAGAACTCTCTCGCAGGTATCCTGCCGTCCGTGTCCCGGCCGGCGAACTGGCGCATTCC
GAACCCACGGAGGATGGTTT

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MEMEREFEEALRNSKTFLRSIDRVITDYPKWRTVVVDLEEFDEPDIAFAVSDDVVEAMKVVQRVAMELIKKERPDVDRVW
VEFRGSPIRLRARDMSVEFKDRLVTVEGIVRRVDNVAAEVVRVEAECPQCGNRFEVRRREYRPDVRCPNCGMRCEPDELF
YTDYQLVVLQEAPEHVRGGEQPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLPSSSPRPGDTGEIVLEAHGVERSDSPL
PEEDLRFTQDEVERFEELAEGDPLGEFVEAVAPHIHGHEVIKKAVSLQLFSCVEEGQIRERVHVLIVGDPATAKSQILQH
VIEHLAPRGVYVSAQHVTGAGLTAAAERTEDGWTLEAGAVVMADGGVIAIDELDKASRGDLNALLEAMESGKISVAKAGI
TTTLNARCAVLAAANPEAGRWQGGHPIEEINLDPALLSRFDVILFTRDEPDPEQDKLVAERMMEAFDGEFDEIEGKYELL
RRYVLYATKEFPNVTISEDAREELRDWFVSARQEAADRIDEGDLRTVPVTRRQMGSVLRLARASARMRLSETVGRGDVSV
ALSVVEEFMKEVMQEDGVLDADVIETGKPKSVREVREYVLKVVRKLAKKHEDGVPKREIVKAVKHRVSRERVEEILDDLV
EEGSLLQPRPGVYLPM

Sequences:

>Translated_656_residues
MEMEREFEEALRNSKTFLRSIDRVITDYPKWRTVVVDLEEFDEPDIAFAVSDDVVEAMKVVQRVAMELIKKERPDVDRVW
VEFRGSPIRLRARDMSVEFKDRLVTVEGIVRRVDNVAAEVVRVEAECPQCGNRFEVRRREYRPDVRCPNCGMRCEPDELF
YTDYQLVVLQEAPEHVRGGEQPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLPSSSPRPGDTGEIVLEAHGVERSDSPL
PEEDLRFTQDEVERFEELAEGDPLGEFVEAVAPHIHGHEVIKKAVSLQLFSCVEEGQIRERVHVLIVGDPATAKSQILQH
VIEHLAPRGVYVSAQHVTGAGLTAAAERTEDGWTLEAGAVVMADGGVIAIDELDKASRGDLNALLEAMESGKISVAKAGI
TTTLNARCAVLAAANPEAGRWQGGHPIEEINLDPALLSRFDVILFTRDEPDPEQDKLVAERMMEAFDGEFDEIEGKYELL
RRYVLYATKEFPNVTISEDAREELRDWFVSARQEAADRIDEGDLRTVPVTRRQMGSVLRLARASARMRLSETVGRGDVSV
ALSVVEEFMKEVMQEDGVLDADVIETGKPKSVREVREYVLKVVRKLAKKHEDGVPKREIVKAVKHRVSRERVEEILDDLV
EEGSLLQPRPGVYLPM
>Mature_656_residues
MEMEREFEEALRNSKTFLRSIDRVITDYPKWRTVVVDLEEFDEPDIAFAVSDDVVEAMKVVQRVAMELIKKERPDVDRVW
VEFRGSPIRLRARDMSVEFKDRLVTVEGIVRRVDNVAAEVVRVEAECPQCGNRFEVRRREYRPDVRCPNCGMRCEPDELF
YTDYQLVVLQEAPEHVRGGEQPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLPSSSPRPGDTGEIVLEAHGVERSDSPL
PEEDLRFTQDEVERFEELAEGDPLGEFVEAVAPHIHGHEVIKKAVSLQLFSCVEEGQIRERVHVLIVGDPATAKSQILQH
VIEHLAPRGVYVSAQHVTGAGLTAAAERTEDGWTLEAGAVVMADGGVIAIDELDKASRGDLNALLEAMESGKISVAKAGI
TTTLNARCAVLAAANPEAGRWQGGHPIEEINLDPALLSRFDVILFTRDEPDPEQDKLVAERMMEAFDGEFDEIEGKYELL
RRYVLYATKEFPNVTISEDAREELRDWFVSARQEAADRIDEGDLRTVPVTRRQMGSVLRLARASARMRLSETVGRGDVSV
ALSVVEEFMKEVMQEDGVLDADVIETGKPKSVREVREYVLKVVRKLAKKHEDGVPKREIVKAVKHRVSRERVEEILDDLV
EEGSLLQPRPGVYLPM

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33469919, Length=547, Percent_Identity=32.3583180987203, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI33469917, Length=547, Percent_Identity=32.3583180987203, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI33356547, Length=583, Percent_Identity=28.9879931389365, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI33469968, Length=508, Percent_Identity=33.6614173228346, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI6631095, Length=548, Percent_Identity=31.2043795620438, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI23510448, Length=578, Percent_Identity=30.2768166089965, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI33469922, Length=512, Percent_Identity=32.421875, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI7427519, Length=619, Percent_Identity=29.0791599353796, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI19923727, Length=640, Percent_Identity=26.25, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI33469924, Length=635, Percent_Identity=26.2992125984252, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI310115110, Length=233, Percent_Identity=32.618025751073, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI310128402, Length=233, Percent_Identity=32.618025751073, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310119838, Length=233, Percent_Identity=32.618025751073, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508417, Length=576, Percent_Identity=30.3819444444444, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71997752, Length=626, Percent_Identity=29.8722044728434, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17562700, Length=606, Percent_Identity=30.6930693069307, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17562702, Length=582, Percent_Identity=31.0996563573883, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17554306, Length=512, Percent_Identity=32.03125, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997563, Length=547, Percent_Identity=27.6051188299817, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71997571, Length=267, Percent_Identity=35.5805243445693, Blast_Score=151, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6325276, Length=602, Percent_Identity=31.063122923588, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6319448, Length=585, Percent_Identity=30.9401709401709, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6319679, Length=566, Percent_Identity=30.7420494699647, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6323304, Length=580, Percent_Identity=28.1034482758621, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321237, Length=311, Percent_Identity=36.9774919614148, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320803, Length=478, Percent_Identity=30.1255230125523, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17137242, Length=595, Percent_Identity=31.7647058823529, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17137132, Length=567, Percent_Identity=31.9223985890653, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24639835, Length=555, Percent_Identity=30.6306306306306, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24645774, Length=598, Percent_Identity=29.933110367893, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17647617, Length=555, Percent_Identity=32.0720720720721, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17530827, Length=558, Percent_Identity=29.3906810035842, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24647251, Length=383, Percent_Identity=28.1984334203655, Blast_Score=119, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 74063; Mature: 74063

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMEREFEEALRNSKTFLRSIDRVITDYPKWRTVVVDLEEFDEPDIAFAVSDDVVEAMKV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEECHHHHHHHHH
VQRVAMELIKKERPDVDRVWVEFRGSPIRLRARDMSVEFKDRLVTVEGIVRRVDNVAAEV
HHHHHHHHHHHCCCCHHHEEEEECCCEEEEEEECCCEEHHHHEEHHHHHHHHHHHHHHHH
VRVEAECPQCGNRFEVRRREYRPDVRCPNCGMRCEPDELFYTDYQLVVLQEAPEHVRGGE
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHCCCC
QPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLPSSSPRPGDTGEIVLEAHGVERSDSPL
CCCEEEEEEEECCCCCCCCCCCEEEEEECEEECCCCCCCCCCCCEEEEEECCCCCCCCCC
PEEDLRFTQDEVERFEELAEGDPLGEFVEAVAPHIHGHEVIKKAVSLQLFSCVEEGQIRE
CHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RVHVLIVGDPATAKSQILQHVIEHLAPRGVYVSAQHVTGAGLTAAAERTEDGWTLEAGAV
EEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCEEECCEE
VMADGGVIAIDELDKASRGDLNALLEAMESGKISVAKAGITTTLNARCAVLAAANPEAGR
EEECCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCEEECCCCEEEEEECCCCCCC
WQGGHPIEEINLDPALLSRFDVILFTRDEPDPEQDKLVAERMMEAFDGEFDEIEGKYELL
CCCCCCHHHCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
RRYVLYATKEFPNVTISEDAREELRDWFVSARQEAADRIDEGDLRTVPVTRRQMGSVLRL
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHH
ARASARMRLSETVGRGDVSVALSVVEEFMKEVMQEDGVLDADVIETGKPKSVREVREYVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
KVVRKLAKKHEDGVPKREIVKAVKHRVSRERVEEILDDLVEEGSLLQPRPGVYLPM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEMEREFEEALRNSKTFLRSIDRVITDYPKWRTVVVDLEEFDEPDIAFAVSDDVVEAMKV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEECHHHHHHHHH
VQRVAMELIKKERPDVDRVWVEFRGSPIRLRARDMSVEFKDRLVTVEGIVRRVDNVAAEV
HHHHHHHHHHHCCCCHHHEEEEECCCEEEEEEECCCEEHHHHEEHHHHHHHHHHHHHHHH
VRVEAECPQCGNRFEVRRREYRPDVRCPNCGMRCEPDELFYTDYQLVVLQEAPEHVRGGE
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHCCCC
QPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLPSSSPRPGDTGEIVLEAHGVERSDSPL
CCCEEEEEEEECCCCCCCCCCCEEEEEECEEECCCCCCCCCCCCEEEEEECCCCCCCCCC
PEEDLRFTQDEVERFEELAEGDPLGEFVEAVAPHIHGHEVIKKAVSLQLFSCVEEGQIRE
CHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RVHVLIVGDPATAKSQILQHVIEHLAPRGVYVSAQHVTGAGLTAAAERTEDGWTLEAGAV
EEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCEEECCEE
VMADGGVIAIDELDKASRGDLNALLEAMESGKISVAKAGITTTLNARCAVLAAANPEAGR
EEECCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCEEECCCCEEEEEECCCCCCC
WQGGHPIEEINLDPALLSRFDVILFTRDEPDPEQDKLVAERMMEAFDGEFDEIEGKYELL
CCCCCCHHHCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
RRYVLYATKEFPNVTISEDAREELRDWFVSARQEAADRIDEGDLRTVPVTRRQMGSVLRL
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHH
ARASARMRLSETVGRGDVSVALSVVEEFMKEVMQEDGVLDADVIETGKPKSVREVREYVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
KVVRKLAKKHEDGVPKREIVKAVKHRVSRERVEEILDDLVEEGSLLQPRPGVYLPM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]