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The map label for this gene is tgtA [H]

Identifier: 20094392

GI number: 20094392

Start: 917639

End: 918091

Strand: Reverse

Name: tgtA [H]

Synonym: MK0956

Alternate gene names: 20094392

Gene position: 918091-917639 (Counterclockwise)

Preceding gene: 20094397

Following gene: 20094391

Centisome position: 54.17

GC content: 68.43

Gene sequence:

>453_bases
ATGAGCCGCTACGTGGAGATCGTGCGTGGGATCCTGGCGTACCAGTTCGGGCGTGAGGCCGCGGACGCGATGCTCGACGG
CGAGGTGAAGGTGCGAGTACGCCGAGGTCGCCCGCGCGAGGTGTTCGTGGACGGGAAAAGGTTGTGCACCGTGAGGGCCT
CGGACGGTCTGGTCTCGCTGGCCCCGGAGGGAGCTCGACGCTTACACGCCGCCACGGAGCCTCCCGAGCACCGCGTGGTC
TGTGCGGACGAGTGGGTCGAGGCCGTGAGGAGGGGTCGCGACCTCTTCTGCGAGTACGCCCTTCGAGGCTGGGAGGAGCT
TCGACCGGGGGACGAGTGCCTAGTGGTTTCGGAGGACGACGAGCTGCTGGCGGTGGGCAAGATGAGGCTCTCGGGGTGGG
AGGTCGAGTACTTCGAGCACGGGGTCGCGGTCCGCGTGCGTCGAGGCCTCTAG

Upstream 100 bases:

>100_bases
TCTCGACGAGTTCTCCCTCGAGGGCGTAAACGACACAGGCGTCGGAGATCTCCTCGGCGTGCCTCAGGAGGACGTCCGGA
TCCAACGGGTGGGTTCCCCC

Downstream 100 bases:

>100_bases
TTAATCCTTTTATCGCCGGATTCGCCCGGGGAGGGAGGGGGACGGGAATTGTTCCCAGGCGGCAAGATCGACCCAAGGAA
GTTGCAGAGACTCATGCGTG

Product: prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit

Products: NA

Alternate protein names: Archaeal tRNA-guanine transglycosylase [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSRYVEIVRGILAYQFGREAADAMLDGEVKVRVRRGRPREVFVDGKRLCTVRASDGLVSLAPEGARRLHAATEPPEHRVV
CADEWVEAVRRGRDLFCEYALRGWEELRPGDECLVVSEDDELLAVGKMRLSGWEVEYFEHGVAVRVRRGL

Sequences:

>Translated_150_residues
MSRYVEIVRGILAYQFGREAADAMLDGEVKVRVRRGRPREVFVDGKRLCTVRASDGLVSLAPEGARRLHAATEPPEHRVV
CADEWVEAVRRGRDLFCEYALRGWEELRPGDECLVVSEDDELLAVGKMRLSGWEVEYFEHGVAVRVRRGL
>Mature_149_residues
SRYVEIVRGILAYQFGREAADAMLDGEVKVRVRRGRPREVFVDGKRLCTVRASDGLVSLAPEGARRLHAATEPPEHRVVC
ADEWVEAVRRGRDLFCEYALRGWEELRPGDECLVVSEDDELLAVGKMRLSGWEVEYFEHGVAVRVRRGL

Specific function: Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs [H]

COG id: COG1370

COG function: function code O; Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PUA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004804
- InterPro:   IPR002478
- InterPro:   IPR015947
- InterPro:   IPR002616
- InterPro:   IPR004521 [H]

Pfam domain/function: PF01472 PUA; PF01702 TGT [H]

EC number: NA

Molecular weight: Translated: 17055; Mature: 16924

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50890 PUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYVEIVRGILAYQFGREAADAMLDGEVKVRVRRGRPREVFVDGKRLCTVRASDGLVSL
CCHHHHHHHHHHHHHHCHHHHHHHCCCEEEEEEECCCCCEEEECCCEEEEEECCCCEEEE
APEGARRLHAATEPPEHRVVCADEWVEAVRRGRDLFCEYALRGWEELRPGDECLVVSEDD
CCCHHHHHCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCHHHCCCCCCEEEEECCC
ELLAVGKMRLSGWEVEYFEHGVAVRVRRGL
CEEEEEEEECCCEEEHHHHCCEEEEEECCC
>Mature Secondary Structure 
SRYVEIVRGILAYQFGREAADAMLDGEVKVRVRRGRPREVFVDGKRLCTVRASDGLVSL
CHHHHHHHHHHHHHHCHHHHHHHCCCEEEEEEECCCCCEEEECCCEEEEEECCCCEEEE
APEGARRLHAATEPPEHRVVCADEWVEAVRRGRDLFCEYALRGWEELRPGDECLVVSEDD
CCCHHHHHCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCHHHCCCCCCEEEEECCC
ELLAVGKMRLSGWEVEYFEHGVAVRVRRGL
CEEEEEEEECCCEEEHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]