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The map label for this gene is SucD [H]

Identifier: 20094169

GI number: 20094169

Start: 698367

End: 699230

Strand: Direct

Name: SucD [H]

Synonym: MK0732

Alternate gene names: 20094169

Gene position: 698367-699230 (Clockwise)

Preceding gene: 20094168

Following gene: 20094170

Centisome position: 41.2

GC content: 62.38

Gene sequence:

>864_bases
TTGTTAGACTCAGACACGCGCGTCCTCGTGCAGGGTATCACGGGCCGGCACGGAAGTTTCCATACGAAGCTAATGCTGGA
GTACGGGACCGAAATCGTCGCCGGCGTAACCCCCGGCCGGGGCGGCCAGGAGGTTCACGGGGTCCCGGTCTACGACACCG
TCGAAGAAGCCGTCGAAGAGACCGACGCCGAGGCTTCCGTCATATTCGTTCCAGCTCCGCAGGCACCCGACGCGGTCATG
GAAGCCATCGAGGCGGGGCTCGATCCCATCGTCGTGATCACCGAGCACATACCGGCTCACGACACCATGCGGTTCGTCGA
GCTAGCCCGGTGGGAAGGTATCCGCATTATCGGCCCTAACACTCCCGGAATCATCGTACCGCCGGAGCGGGTGAAGCTGG
GGATCATGCCTCATCAAGTGTTCACCGAGGGTGAAGTGGCCGTAGCGTCGAGGAGCGGTACCCTCACGTACGAGATCGTT
CAGGCGATGACCGAGGCCGGACTCGGTCAGTCCCTCTGCGTGGGACTCGGGGGCGACCAAATCGTCGGAACTACCTTCAT
AGACTTCTTGGAGTACGTCCGGGAAGATGATCGCACCGAGGCCGTGGTTCTCATCGGGGAGATAGGTGGAAATGCGGAAG
AGCTCGCCGCCGAGTACATCGCGGAAACCGACTTCCCGAAGCCCGTCGTCGCCTACATCGCCGGCCGTCACGCCCCACCC
GGCAAACGTATGGGCCACGCCGGGGCCATCATCGAGAGAGGTCGTGGAACCGCGGAGTCCAAGATCGAAGCTTTCCGAAA
GGCAGGAGTCGATGTAGCCGAGAAGCCGTGGGAAGTGCCGGAGCTGCTTCGGGAGTACCTCTAG

Upstream 100 bases:

>100_bases
GGAGGAAGGTCATCGCATACTCCGCGAGCACGGGGTCGACGTCTACACCGAGCTTAAGGAGGCGGTCGAACGCGCGGTCG
AGTTAGCGGGGGCTTAGCCC

Downstream 100 bases:

>100_bases
TTGAAACTCTCCGTCCCCGGTGCCCTGACGGGCTTTTTTCACCCGCAGCCCGGTAAGACGCCGAAAGACACAGGATCGCC
CGGCTTCGGCCTAGCCGTCG

Product: succinyl-CoA synthetase alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MLDSDTRVLVQGITGRHGSFHTKLMLEYGTEIVAGVTPGRGGQEVHGVPVYDTVEEAVEETDAEASVIFVPAPQAPDAVM
EAIEAGLDPIVVITEHIPAHDTMRFVELARWEGIRIIGPNTPGIIVPPERVKLGIMPHQVFTEGEVAVASRSGTLTYEIV
QAMTEAGLGQSLCVGLGGDQIVGTTFIDFLEYVREDDRTEAVVLIGEIGGNAEELAAEYIAETDFPKPVVAYIAGRHAPP
GKRMGHAGAIIERGRGTAESKIEAFRKAGVDVAEKPWEVPELLREYL

Sequences:

>Translated_287_residues
MLDSDTRVLVQGITGRHGSFHTKLMLEYGTEIVAGVTPGRGGQEVHGVPVYDTVEEAVEETDAEASVIFVPAPQAPDAVM
EAIEAGLDPIVVITEHIPAHDTMRFVELARWEGIRIIGPNTPGIIVPPERVKLGIMPHQVFTEGEVAVASRSGTLTYEIV
QAMTEAGLGQSLCVGLGGDQIVGTTFIDFLEYVREDDRTEAVVLIGEIGGNAEELAAEYIAETDFPKPVVAYIAGRHAPP
GKRMGHAGAIIERGRGTAESKIEAFRKAGVDVAEKPWEVPELLREYL
>Mature_287_residues
MLDSDTRVLVQGITGRHGSFHTKLMLEYGTEIVAGVTPGRGGQEVHGVPVYDTVEEAVEETDAEASVIFVPAPQAPDAVM
EAIEAGLDPIVVITEHIPAHDTMRFVELARWEGIRIIGPNTPGIIVPPERVKLGIMPHQVFTEGEVAVASRSGTLTYEIV
QAMTEAGLGQSLCVGLGGDQIVGTTFIDFLEYVREDDRTEAVVLIGEIGGNAEELAAEYIAETDFPKPVVAYIAGRHAPP
GKRMGHAGAIIERGRGTAESKIEAFRKAGVDVAEKPWEVPELLREYL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=282, Percent_Identity=53.5460992907801, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI38569423, Length=251, Percent_Identity=29.4820717131474, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI38569421, Length=251, Percent_Identity=29.4820717131474, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=51.9163763066202, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=49.4845360824742, Blast_Score=258, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17550194, Length=282, Percent_Identity=50.709219858156, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17557344, Length=311, Percent_Identity=27.0096463022508, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=311, Percent_Identity=26.6881028938907, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=46.2585034013605, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=48.2758620689655, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI28574296, Length=289, Percent_Identity=51.2110726643599, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI281363477, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363475, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363473, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30872; Mature: 30872

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSDTRVLVQGITGRHGSFHTKLMLEYGTEIVAGVTPGRGGQEVHGVPVYDTVEEAVEE
CCCCCCEEEEECCCCCCCCHHHEEHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
TDAEASVIFVPAPQAPDAVMEAIEAGLDPIVVITEHIPAHDTMRFVELARWEGIRIIGPN
CCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCC
TPGIIVPPERVKLGIMPHQVFTEGEVAVASRSGTLTYEIVQAMTEAGLGQSLCVGLGGDQ
CCCEEECCCCEEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCC
IVGTTFIDFLEYVREDDRTEAVVLIGEIGGNAEELAAEYIAETDFPKPVVAYIAGRHAPP
CHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GKRMGHAGAIIERGRGTAESKIEAFRKAGVDVAEKPWEVPELLREYL
CCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
>Mature Secondary Structure
MLDSDTRVLVQGITGRHGSFHTKLMLEYGTEIVAGVTPGRGGQEVHGVPVYDTVEEAVEE
CCCCCCEEEEECCCCCCCCHHHEEHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
TDAEASVIFVPAPQAPDAVMEAIEAGLDPIVVITEHIPAHDTMRFVELARWEGIRIIGPN
CCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCC
TPGIIVPPERVKLGIMPHQVFTEGEVAVASRSGTLTYEIVQAMTEAGLGQSLCVGLGGDQ
CCCEEECCCCEEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCC
IVGTTFIDFLEYVREDDRTEAVVLIGEIGGNAEELAAEYIAETDFPKPVVAYIAGRHAPP
CHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GKRMGHAGAIIERGRGTAESKIEAFRKAGVDVAEKPWEVPELLREYL
CCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]