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The map label for this gene is CdhE

Identifier: 20094160

GI number: 20094160

Start: 691014

End: 692402

Strand: Direct

Name: CdhE

Synonym: MK0723

Alternate gene names: 20094160

Gene position: 691014-692402 (Clockwise)

Preceding gene: 20094159

Following gene: 20094161

Centisome position: 40.77

GC content: 60.62

Gene sequence:

>1389_bases
GTGGCCCAGCTCAGCGCGATGGACGTGTACAACCTGCTACCCAAGGCCAACTGCGGGGCGTGTGGCTGCAAGACCTGCAT
GGAATTCGCTACGAAGCTCGTCAATCGGGAGGCGAAGCCCGAGGATTGCCCGAAGCTCGACGATGAGAGCCTAGAGAAGC
TTCAGGAGCTGCTAGCGCCGCCAGTCAAGGAGCTGACGATAGGGGAAGGGGACCGCGAAGTCACCGTCGGCGGCGATGAG
GTGATGTTCCGACACGAGCTCTCGTTCTTCAACCCACCGCCGGTGTTCGTCACCGTTTACGACGACATGGAGGAGGACGA
AATCGCCGGAAAGACGGAGGAAATTCAGGAGTTTCAAGTCGAACGCGTTGGAGAGGTCCTGAAGCTTGACGGCGTCGCGG
TGGTATCCCGAACGGGGGACCCCGAGAAGTACGCTCGGGCGGTTGAGATCGCGGTGGAGCGCTCTGAGGACCTCGCCGTG
GCGTTGATCACCACTGATCCTAAGGTGATGGAAGCTGGTCTCGACGTTTTCGACGAACGTCCGCTGCTTTATCCGGCGAC
CGAGGAGAACGTCGAGGACCTAGCGAAGCTAGCGGCCGATGGGGACTGTCCCCTGGGACTTCACGCCCGTGACGTCGAAG
ACCTCGTACCCCTGGTCGTCGAGGCGCAGCAGTACACGGACGATCTGCTCCTGGACCCGGGTACGGAGTTCGGTCCCCAC
GACGTGGTTTCTACCACGGACAAGCTGGCGGAGATCCGCAAGGCGGCTATCGAGGAGTTCGAGAGCTTCGGTTACCCGAC
CCTCGTTACGACGTTTCCCTACGCGTTCCTCGAAGATGATCCCGTAAAAGCCGCTAGACGGGAATCGTACCTAGCGTCCG
CCTGTGTGCTAAGGTACGCCGACATCCTTATCATGGACACCGTAGAACCTTGGGCGCTCCTTCCGGTGCTAACCCAGCGT
CAGTGCGTGTACACCGACCCACGGGAGCCTCAGGAAGTAGAACCCGGCCTGTACAGGATCGGTGACCCGGACGAGAATTC
TCCTGTGTTAGTCACGACGAACTTCACGCTGACGTACCACTGTGTGGCCGGCGACCTCGAGAGCGCCGACATCGACTGTT
GGCTGCTGGTCATCGATACCGGCGGACTAGCCGTAGACGTCAGCGTTGCCGGCGGTCAGTTCACGGGGGAGGCCGTGAAG
GAAGTCATCGAGGAGACGGACATCGAGGACAAGGTCGAACATCGTGTCCTTGTGATCCCGGGCAAGGCCGCCGCCGTGAA
AGGGGACGTGGAGGACGCCACCGGCTGGGACGTGATGATCGGTACTCAGGACTCGTCCGAGCTGCCTGAGTTTCTGGAGA
AAGAAGGTCTACTGAGGATTGAGGAATGA

Upstream 100 bases:

>100_bases
GCCGTGCAAGTGGTTATGGAGGCTATGGAGTACATGGCCGAAGGACGCGTCACCGGAGACGCGTACGTGACCGACGTGAT
CGCCTGAGGGGGAGACGCTC

Downstream 100 bases:

>100_bases
CCGGCGACTTTATCCTTCCCCAACCCTGGCGCTAGGGACCTCGGGGATGAGCTGTTGATCCTGGTGACCGGAGGAGCCGG
GTTCATAGGTTCGCACGTCG

Product: acetyl-CoA decarbonylase/synthase complex subunit gamma

Products: CO2; AH2

Alternate protein names: ACDS complex subunit gamma; ACDS complex methyltransferase; Corrinoid/iron-sulfur component large subunit

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAQLSAMDVYNLLPKANCGACGCKTCMEFATKLVNREAKPEDCPKLDDESLEKLQELLAPPVKELTIGEGDREVTVGGDE
VMFRHELSFFNPPPVFVTVYDDMEEDEIAGKTEEIQEFQVERVGEVLKLDGVAVVSRTGDPEKYARAVEIAVERSEDLAV
ALITTDPKVMEAGLDVFDERPLLYPATEENVEDLAKLAADGDCPLGLHARDVEDLVPLVVEAQQYTDDLLLDPGTEFGPH
DVVSTTDKLAEIRKAAIEEFESFGYPTLVTTFPYAFLEDDPVKAARRESYLASACVLRYADILIMDTVEPWALLPVLTQR
QCVYTDPREPQEVEPGLYRIGDPDENSPVLVTTNFTLTYHCVAGDLESADIDCWLLVIDTGGLAVDVSVAGGQFTGEAVK
EVIEETDIEDKVEHRVLVIPGKAAAVKGDVEDATGWDVMIGTQDSSELPEFLEKEGLLRIEE

Sequences:

>Translated_462_residues
MAQLSAMDVYNLLPKANCGACGCKTCMEFATKLVNREAKPEDCPKLDDESLEKLQELLAPPVKELTIGEGDREVTVGGDE
VMFRHELSFFNPPPVFVTVYDDMEEDEIAGKTEEIQEFQVERVGEVLKLDGVAVVSRTGDPEKYARAVEIAVERSEDLAV
ALITTDPKVMEAGLDVFDERPLLYPATEENVEDLAKLAADGDCPLGLHARDVEDLVPLVVEAQQYTDDLLLDPGTEFGPH
DVVSTTDKLAEIRKAAIEEFESFGYPTLVTTFPYAFLEDDPVKAARRESYLASACVLRYADILIMDTVEPWALLPVLTQR
QCVYTDPREPQEVEPGLYRIGDPDENSPVLVTTNFTLTYHCVAGDLESADIDCWLLVIDTGGLAVDVSVAGGQFTGEAVK
EVIEETDIEDKVEHRVLVIPGKAAAVKGDVEDATGWDVMIGTQDSSELPEFLEKEGLLRIEE
>Mature_461_residues
AQLSAMDVYNLLPKANCGACGCKTCMEFATKLVNREAKPEDCPKLDDESLEKLQELLAPPVKELTIGEGDREVTVGGDEV
MFRHELSFFNPPPVFVTVYDDMEEDEIAGKTEEIQEFQVERVGEVLKLDGVAVVSRTGDPEKYARAVEIAVERSEDLAVA
LITTDPKVMEAGLDVFDERPLLYPATEENVEDLAKLAADGDCPLGLHARDVEDLVPLVVEAQQYTDDLLLDPGTEFGPHD
VVSTTDKLAEIRKAAIEEFESFGYPTLVTTFPYAFLEDDPVKAARRESYLASACVLRYADILIMDTVEPWALLPVLTQRQ
CVYTDPREPQEVEPGLYRIGDPDENSPVLVTTNFTLTYHCVAGDLESADIDCWLLVIDTGGLAVDVSVAGGQFTGEAVKE
VIEETDIEDKVEHRVLVIPGKAAAVKGDVEDATGWDVMIGTQDSSELPEFLEKEGLLRIEE

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2)

COG id: COG1456

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDG_METKA (Q8TXF1)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614007.1
- ProteinModelPortal:   Q8TXF1
- GeneID:   1476824
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0723
- NMPDR:   fig|190192.1.peg.720
- HOGENOM:   HBG304431
- OMA:   YTDPRKP
- ProtClustDB:   PRK04165
- BioCyc:   MKAN190192:MK0723-MONOMER
- HAMAP:   MF_01136
- InterPro:   IPR016041
- InterPro:   IPR016218
- InterPro:   IPR011005
- InterPro:   IPR007202
- PIRSF:   PIRSF000376

Pfam domain/function: PF03599 CdhD; PF04060 FeS; SSF51717 DHP_synth_like

EC number: 1.2.99.2

Molecular weight: Translated: 50853; Mature: 50721

Theoretical pI: Translated: 3.90; Mature: 3.90

Prosite motif: PS00198 4FE4S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLSAMDVYNLLPKANCGACGCKTCMEFATKLVNREAKPEDCPKLDDESLEKLQELLAP
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
PVKELTIGEGDREVTVGGDEVMFRHELSFFNPPPVFVTVYDDMEEDEIAGKTEEIQEFQV
CHHEEECCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHH
ERVGEVLKLDGVAVVSRTGDPEKYARAVEIAVERSEDLAVALITTDPKVMEAGLDVFDER
HHHHHHHEECCEEEEECCCCHHHHHHHHHHHEECCCCEEEEEEECCHHHHHHCCHHHCCC
PLLYPATEENVEDLAKLAADGDCPLGLHARDVEDLVPLVVEAQQYTDDLLLDPGTEFGPH
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCC
DVVSTTDKLAEIRKAAIEEFESFGYPTLVTTFPYAFLEDDPVKAARRESYLASACVLRYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
DILIMDTVEPWALLPVLTQRQCVYTDPREPQEVEPGLYRIGDPDENSPVLVTTNFTLTYH
CEEEEECCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCCCCCEEEEEEEEEEEE
CVAGDLESADIDCWLLVIDTGGLAVDVSVAGGQFTGEAVKEVIEETDIEDKVEHRVLVIP
EEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHCCEEEEEC
GKAAAVKGDVEDATGWDVMIGTQDSSELPEFLEKEGLLRIEE
CCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEECC
>Mature Secondary Structure 
AQLSAMDVYNLLPKANCGACGCKTCMEFATKLVNREAKPEDCPKLDDESLEKLQELLAP
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
PVKELTIGEGDREVTVGGDEVMFRHELSFFNPPPVFVTVYDDMEEDEIAGKTEEIQEFQV
CHHEEECCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHH
ERVGEVLKLDGVAVVSRTGDPEKYARAVEIAVERSEDLAVALITTDPKVMEAGLDVFDER
HHHHHHHEECCEEEEECCCCHHHHHHHHHHHEECCCCEEEEEEECCHHHHHHCCHHHCCC
PLLYPATEENVEDLAKLAADGDCPLGLHARDVEDLVPLVVEAQQYTDDLLLDPGTEFGPH
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCC
DVVSTTDKLAEIRKAAIEEFESFGYPTLVTTFPYAFLEDDPVKAARRESYLASACVLRYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
DILIMDTVEPWALLPVLTQRQCVYTDPREPQEVEPGLYRIGDPDENSPVLVTTNFTLTYH
CEEEEECCCCHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCCCCCEEEEEEEEEEEE
CVAGDLESADIDCWLLVIDTGGLAVDVSVAGGQFTGEAVKEVIEETDIEDKVEHRVLVIP
EEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHCCEEEEEC
GKAAAVKGDVEDATGWDVMIGTQDSSELPEFLEKEGLLRIEE
CCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014