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The map label for this gene is MtrH

Identifier: 20094100

GI number: 20094100

Start: 620318

End: 621286

Strand: Direct

Name: MtrH

Synonym: MK0662

Alternate gene names: 20094100

Gene position: 620318-621286 (Clockwise)

Preceding gene: 20094099

Following gene: 20094102

Centisome position: 36.6

GC content: 63.05

Gene sequence:

>969_bases
TTGTTCTACTACCCGGGTAAGGAGCAGAAGGTGTGCGACATCTGCGGTGTGAAGGTCGGTGGCCAGCCCGGTGAGTACCC
GACCGTGCTAGCCGGTACCATCTTCTATGCCGGACACAAGATCGTGAAGGACGAGGACAAGGGGATCTTCGACGAGGAGG
CCGCCGAGGAGCTCATCAAGATGGAGGAGGAACTCGCCGACGAGACCGGTAACCCGATGATGGCCCACATCATGGGTGAG
TCAGAAGAGGCCATCATCCGCTACCTCGACTGGGTAGCCGACGTTACCGACGCACCCATCATCGTGGACTCCACCGAAGC
CGAGGTCAAGGTCGCGGCGGTAAAGCACGCTCAGGAGGTCGGCCTCGCCGAGCGGGTGGTCTACAACTCGATCAACGCCT
CCGTCGAGGACGAGGAGATCCAGGCCATCAAGGAGTCCGACTGCAACTCGGCGATCGTCCTGGCCTTCAACCCGATGGAC
GCTTCCGTCGAGGGCCGTATGAAAATCCTCACCGAGGGCGAGGAGGGAGTATCCGAGAAGGGCATGCTGGAGATCTCCGA
CGAGTGTGGCATCGAGAACCCGCTGATCGACACAGCCTACACGCCGTTCGGCTCCGGTGCGGGTACCGCTTACAAGGTGA
CGCTCGCGGTGAAGGCCAAGCTGGGCCTGCCGGTGGGCGGTGCGCCCCACAACGTGCCGTCCGCTTGGGACTGGCTACGT
GACTTCATGAAGAAGCTCAAGGAGGAAGGCAAGGAAGAGTGGGCCGAGCTAGCCCACGAGTCCTCCGACTGGGGCTCCAA
CGTAGTGGCGGCGACGCTGTGCTGCGACTACCTGCTGTTCGGTCCGATCGAGAACGCGCCGGCGATCTGGCCGGTCGTCG
CCATGGTCGACGCGCTGATCGTCGAGGCCAACGAGGACGTCGGCGTCGAGCCGCAGGTGGAGGAGCACCCGGCCAACATC
GTCCGCTAA

Upstream 100 bases:

>100_bases
ATAGGGATCCTTTACGGTCTGGTGATCGGGCTGTACCTGTGTATGCTTTACATCCTGCTGGGAGTAGCGTTCAGGTGACA
ACCTTGGGGGTGTTGGACCG

Downstream 100 bases:

>100_bases
CGCCACAGACCCCGTTTTTTTCGCTTCCAACAGTCTCTCCCGGGCGTACTCGACCGCGTACGGATTCTCGTCCGAGAACC
TCGGACCGTACCGCTCCAGA

Product: tetrahydromethanopterin S-methyltransferase subunit H

Products: NA

Alternate protein names: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIKMEEELADETGNPMMAHIMGE
SEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEVGLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMD
ASVEGRMKILTEGEEGVSEKGMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLR
DFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALIVEANEDVGVEPQVEEHPANI
VR

Sequences:

>Translated_322_residues
MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIKMEEELADETGNPMMAHIMGE
SEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEVGLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMD
ASVEGRMKILTEGEEGVSEKGMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLR
DFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALIVEANEDVGVEPQVEEHPANI
VR
>Mature_322_residues
MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIKMEEELADETGNPMMAHIMGE
SEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEVGLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMD
ASVEGRMKILTEGEEGVSEKGMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLR
DFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALIVEANEDVGVEPQVEEHPANI
VR

Specific function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl grou

COG id: COG1962

COG function: function code H; Tetrahydromethanopterin S-methyltransferase, subunit H

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mtrH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRH_METKA (O32869)

Other databases:

- EMBL:   Y14428
- EMBL:   AE009439
- RefSeq:   NP_613947.1
- ProteinModelPortal:   O32869
- GeneID:   1476763
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0662
- NMPDR:   fig|190192.1.peg.660
- HOGENOM:   HBG512918
- OMA:   YARHKIV
- ProtClustDB:   PRK00979
- BioCyc:   MKAN190192:MK0662-MONOMER
- BRENDA:   2.1.1.86
- GO:   GO:0015948
- HAMAP:   MF_01501
- InterPro:   IPR011005
- InterPro:   IPR002856
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- ProDom:   PD009948
- TIGRFAMs:   TIGR01114

Pfam domain/function: PF02007 MtrH; SSF51717 DHP_synth_like

EC number: =2.1.1.86

Molecular weight: Translated: 34964; Mature: 34964

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIK
CCCCCCCCCCHHHHHCEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHH
MEEELADETGNPMMAHIMGESEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEV
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHH
GLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMDASVEGRMKILTEGEEGVSEK
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCC
GMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLR
CCEEECHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHH
DFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VEANEDVGVEPQVEEHPANIVR
EECCCCCCCCCCHHHCCHHCCC
>Mature Secondary Structure
MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIK
CCCCCCCCCCHHHHHCEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHH
MEEELADETGNPMMAHIMGESEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEV
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHH
GLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMDASVEGRMKILTEGEEGVSEK
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCC
GMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLR
CCEEECHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHH
DFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VEANEDVGVEPQVEEHPANIVR
EECCCCCCCCCCHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9461302; 11930014