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The map label for this gene is MtrE

Identifier: 20094094

GI number: 20094094

Start: 616411

End: 617307

Strand: Direct

Name: MtrE

Synonym: MK0656

Alternate gene names: 20094094

Gene position: 616411-617307 (Clockwise)

Preceding gene: 20094093

Following gene: 20094095

Centisome position: 36.37

GC content: 62.76

Gene sequence:

>897_bases
TTGGTAGGGTTCACCGAGATCGGTTTAGCGGCCGCGATGGGCGCGCTGGCCACCATAGCCGGAGCGTTCGAGGACGCCGA
GTCGGACGTAGGATCCCAGTCCAACCCGAACTCGCAGGTCCAGCTGGCGCCGCAAATGATGAACTTCCACAGGTACTTCA
ACAAGGCGATCTCGGGAGAGCCAGTTTCCTACATGCTGTACGGAGCGATCGCCGGTACGGTAACCTGGGTGATGATGACC
AAGTTCGGGCTTCCGTTCCTCGCCGCCGCGGCGGTAGGCGTCGGTGTGAACGCACTAATTCACATGGTGTTCGCGACCAC
GGCCCACCTGGGTAGAATGGCGAGCGCGGCCGAGTTCGGACACCCGATCTACCTGGACGTCGTACTCTCACACCTCGGGC
CGATCGCGGGCTTCGGAGGGATCGCGACCTTCGCGATAGTATCGCTGGCCTACATCCAGTGGGCGCTCCTGAAGCACCCG
TTCCCGCTGCCATTGCTGGCCGCACTATGGGGCGTAACGGTCGGCGCGATCGGATCCTCGACGGGAGACGTGCACTACGG
TGCTGAGCGTCTGTACCAGCACTACCCGTTCGGCGGCGGTGTTCCGGTAGCCGCTCACGGTAACATCACGCGGAAGGCCG
AGACCGGAATCCGGAACTCGATGGACAGCGTCTACTTCTGCGCCAAGTTCGGTAACCCGCTCACGGGCCTGTGTTTCGGT
CTGGTGGTGTTCTTCAGCACCTGGGCCGGCCTGTTCGGGCAGTGGGGCGCCGTGATCGCCATGGGCCTGGTCACGCTCGG
GTGCCTGATCGTGAGTAACCGTGTGGAGAAGAAGGCCCGCGAGAGCTACGGTACCTACGAGGACGTCGAGATGGACGAGA
TCTGTGATCCGGTGTAA

Upstream 100 bases:

>100_bases
ACTTTTAAACCGAAGTTCGGGAACTTCCGCGAAATCGTTTCAACACCCTTAACGTGAGTTCACTTTCGTAGCTCTCAACT
CGAGTTTAGGGGGTACGCCC

Downstream 100 bases:

>100_bases
GGGGGACCCCGCGTTGGGTGAGTCCGCCAAGCTGAACGCCCGAGGGTTCGGGATCGCCCTGTCCCTGATCGCCGTGGCGA
CGATCCTGGCGACCTTCGGA

Product: tetrahydromethanopterin S-methyltransferase subunit E

Products: NA

Alternate protein names: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MVGFTEIGLAAAMGALATIAGAFEDAESDVGSQSNPNSQVQLAPQMMNFHRYFNKAISGEPVSYMLYGAIAGTVTWVMMT
KFGLPFLAAAAVGVGVNALIHMVFATTAHLGRMASAAEFGHPIYLDVVLSHLGPIAGFGGIATFAIVSLAYIQWALLKHP
FPLPLLAALWGVTVGAIGSSTGDVHYGAERLYQHYPFGGGVPVAAHGNITRKAETGIRNSMDSVYFCAKFGNPLTGLCFG
LVVFFSTWAGLFGQWGAVIAMGLVTLGCLIVSNRVEKKARESYGTYEDVEMDEICDPV

Sequences:

>Translated_298_residues
MVGFTEIGLAAAMGALATIAGAFEDAESDVGSQSNPNSQVQLAPQMMNFHRYFNKAISGEPVSYMLYGAIAGTVTWVMMT
KFGLPFLAAAAVGVGVNALIHMVFATTAHLGRMASAAEFGHPIYLDVVLSHLGPIAGFGGIATFAIVSLAYIQWALLKHP
FPLPLLAALWGVTVGAIGSSTGDVHYGAERLYQHYPFGGGVPVAAHGNITRKAETGIRNSMDSVYFCAKFGNPLTGLCFG
LVVFFSTWAGLFGQWGAVIAMGLVTLGCLIVSNRVEKKARESYGTYEDVEMDEICDPV
>Mature_298_residues
MVGFTEIGLAAAMGALATIAGAFEDAESDVGSQSNPNSQVQLAPQMMNFHRYFNKAISGEPVSYMLYGAIAGTVTWVMMT
KFGLPFLAAAAVGVGVNALIHMVFATTAHLGRMASAAEFGHPIYLDVVLSHLGPIAGFGGIATFAIVSLAYIQWALLKHP
FPLPLLAALWGVTVGAIGSSTGDVHYGAERLYQHYPFGGGVPVAAHGNITRKAETGIRNSMDSVYFCAKFGNPLTGLCFG
LVVFFSTWAGLFGQWGAVIAMGLVTLGCLIVSNRVEKKARESYGTYEDVEMDEICDPV

Specific function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step

COG id: COG4059

COG function: function code H; Tetrahydromethanopterin S-methyltransferase, subunit E

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mtrE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRE_METKA (Q49606)

Other databases:

- EMBL:   Y14428
- EMBL:   AE009439
- EMBL:   U57340
- RefSeq:   NP_613941.1
- GeneID:   1476757
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0656
- NMPDR:   fig|190192.1.peg.654
- HOGENOM:   HBG539646
- OMA:   SNPNSQV
- ProtClustDB:   PRK00972
- BioCyc:   MKAN190192:MK0656-MONOMER
- BRENDA:   2.1.1.86
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01098
- InterPro:   IPR005780
- PIRSF:   PIRSF016509
- TIGRFAMs:   TIGR01113

Pfam domain/function: PF04206 MtrE

EC number: =2.1.1.86

Molecular weight: Translated: 31528; Mature: 31528

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xce03f14)-; HASH(0xb480c64)-; HASH(0xcf3ee60)-; HASH(0xd336460)-; HASH(0xd500dcc)-; HASH(0xb48e140)-; HASH(0xd5c1640)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGFTEIGLAAAMGALATIAGAFEDAESDVGSQSNPNSQVQLAPQMMNFHRYFNKAISGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCC
PVSYMLYGAIAGTVTWVMMTKFGLPFLAAAAVGVGVNALIHMVFATTAHLGRMASAAEFG
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPIYLDVVLSHLGPIAGFGGIATFAIVSLAYIQWALLKHPFPLPLLAALWGVTVGAIGSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
TGDVHYGAERLYQHYPFGGGVPVAAHGNITRKAETGIRNSMDSVYFCAKFGNPLTGLCFG
CCCCHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LVVFFSTWAGLFGQWGAVIAMGLVTLGCLIVSNRVEKKARESYGTYEDVEMDEICDPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9461302; 11930014; 8863453