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The map label for this gene is MtrD

Identifier: 20094095

GI number: 20094095

Start: 617423

End: 618100

Strand: Direct

Name: MtrD

Synonym: MK0657

Alternate gene names: 20094095

Gene position: 617423-618100 (Clockwise)

Preceding gene: 20094094

Following gene: 20094096

Centisome position: 36.43

GC content: 61.65

Gene sequence:

>678_bases
GTGGACAAGCTGATCGCGGTGCTGGTACTGATCACGCTCGGTAGTATCATGGTGAACGTCGGTGTACACTACGTGCCGGT
GGGAGGCGCTCCGGCCGCGATGGCGACGGCGACGGGAGTGGGTACAGGTACCACCCAGCTGGCGGCGGGATCCGGACTGA
CCGGACTTATCACGGCGGCGGCCATGAGCCAGAAGCCGTTCCTCGTGATCCTGTGGAACGGTGCCCTCGGAGCCGCTACA
ATGATGGCCATCACCATGCTGGTGGGTAACTTCATCTACGTCTACGGTGTCGGTTGTCCACCGTGCTCCGCTAAGGTCGA
CAAGGACCCGATCACCGGCTGGGACCAGGAGGCGTACGTCACGCCCGGTACGGAGGGTCACGGAATCCCGACGGTCAGCT
TCGTGAGCGGGATCCTCGGAGGACTGCTCGGAGGTTCCGGCGGTGCGATGGTGTACTACGCGCTCTACAAGGTGCTCGGA
ATGAGCGCGGCGCTGGCCGGGATACTGGCCATGGGCTTCTTCTACGCGAACGCGGTGCTGGCGTCGTACAACATCGGAGG
TACGATCGAGGGTTACCACGATCCGAAGTTCACGAGGCTACCGAAGGCGGTAGTATGCTCCCTAGTATTCGGTATAGTAG
CGTCCGTGATCGCGTATTACCTCTCGACCCTCATGTAA

Upstream 100 bases:

>100_bases
GGGTGAGTCCGCCAAGCTGAACGCCCGAGGGTTCGGGATCGCCCTGTCCCTGATCGCCGTGGCGACGATCCTGGCGACCT
TCGGACACTTCTGGACGTCC

Downstream 100 bases:

>100_bases
CGGGGGAGTGTGAGGAACCTTGATCCTGCGTACACTCCTGATCTCCGCCGTAGCACCGGGTGGCGAGGAGGAAGAGGTAG
AGGTCGCCGTAGCGATCTCG

Product: tetrahydromethanopterin S-methyltransferase subunit D

Products: NA

Alternate protein names: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDKLIAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAGSGLTGLITAAAMSQKPFLVILWNGALGAAT
MMAITMLVGNFIYVYGVGCPPCSAKVDKDPITGWDQEAYVTPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLG
MSAALAGILAMGFFYANAVLASYNIGGTIEGYHDPKFTRLPKAVVCSLVFGIVASVIAYYLSTLM

Sequences:

>Translated_225_residues
MDKLIAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAGSGLTGLITAAAMSQKPFLVILWNGALGAAT
MMAITMLVGNFIYVYGVGCPPCSAKVDKDPITGWDQEAYVTPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLG
MSAALAGILAMGFFYANAVLASYNIGGTIEGYHDPKFTRLPKAVVCSLVFGIVASVIAYYLSTLM
>Mature_225_residues
MDKLIAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAGSGLTGLITAAAMSQKPFLVILWNGALGAAT
MMAITMLVGNFIYVYGVGCPPCSAKVDKDPITGWDQEAYVTPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLG
MSAALAGILAMGFFYANAVLASYNIGGTIEGYHDPKFTRLPKAVVCSLVFGIVASVIAYYLSTLM

Specific function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step

COG id: COG4060

COG function: function code H; Tetrahydromethanopterin S-methyltransferase, subunit D

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mtrD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRD_METKA (O32864)

Other databases:

- EMBL:   Y14428
- EMBL:   AE009439
- RefSeq:   NP_613942.1
- ProteinModelPortal:   O32864
- GeneID:   1476758
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0657
- NMPDR:   fig|190192.1.peg.655
- HOGENOM:   HBG551221
- OMA:   HFVPVGG
- ProtClustDB:   PRK00968
- BioCyc:   MKAN190192:MK0657-MONOMER
- BRENDA:   2.1.1.86
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01097
- InterPro:   IPR005779
- PIRSF:   PIRSF016552
- ProDom:   PD013594
- TIGRFAMs:   TIGR01112

Pfam domain/function: PF04207 MtrD

EC number: =2.1.1.86

Molecular weight: Translated: 22872; Mature: 22872

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcde18dc)-; HASH(0xcf80728)-; HASH(0xcc6d870)-; HASH(0xceea8f4)-; HASH(0xd03cf98)-; HASH(0xd54f570)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLIAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAGSGLTGLITAA
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCHHHCCCCCHHHHHHHH
AMSQKPFLVILWNGALGAATMMAITMLVGNFIYVYGVGCPPCSAKVDKDPITGWDQEAYV
HHCCCCEEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
TPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLGMSAALAGILAMGFFYANAVL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASYNIGGTIEGYHDPKFTRLPKAVVCSLVFGIVASVIAYYLSTLM
HHCCCCCEECCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MDKLIAVLVLITLGSIMVNVGVHYVPVGGAPAAMATATGVGTGTTQLAAGSGLTGLITAA
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCHHHCCCCCHHHHHHHH
AMSQKPFLVILWNGALGAATMMAITMLVGNFIYVYGVGCPPCSAKVDKDPITGWDQEAYV
HHCCCCEEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
TPGTEGHGIPTVSFVSGILGGLLGGSGGAMVYYALYKVLGMSAALAGILAMGFFYANAVL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASYNIGGTIEGYHDPKFTRLPKAVVCSLVFGIVASVIAYYLSTLM
HHCCCCCEECCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9461302; 11930014