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The map label for this gene is 20094080

Identifier: 20094080

GI number: 20094080

Start: 601360

End: 602079

Strand: Direct

Name: 20094080

Synonym: MK0642

Alternate gene names: NA

Gene position: 601360-602079 (Clockwise)

Preceding gene: 20094079

Following gene: 20094082

Centisome position: 35.48

GC content: 69.58

Gene sequence:

>720_bases
ATGGGCGTGTTCGGGTACTTGCGGGAGCGCACCCCCTGTCATCTCACCCTGCTCGACCCCGTGGACGTGGGTCCGGAGGA
GGTCCCGGAGGTCCTGGAGTCGCTGGTGAAGGCGGGCACGGACGCGGTGATGGTCGGCGGTTCGACTGCGCACGCATCGC
AGGTGGAAGCGGTGGTGGAGGCGATCCGGGAGGTCGCGGACGTCCCGGTGATCCTGTTCCCGAACGGCCCGGAAGGTCTC
GCGCCGAACGCGGACGCGGTGCTGTTCATGAGCCTACTCAACTCGCGGAACACGTACTACCTGATCGAGGCGCAGGTGAA
GGGCGCGCCGTTGGTGGAGCGGTTCGGGCTGGAATCGATCCCGACGGGCTACCTGATCGTGGGCGAGTGGGGTACGACCG
TCTCGGTGGTCGGAGACGCGCGGGTGATCCCGTTCGATCGGGTCGAGGTGATCGTCGCGTACGCGCTGGCGGCGAAGCAC
CTGGGCATGAAGGCGGTGTACCTGGAGGCGGGGAGCGGTGCGCCGGAGCCGGTGCCGCCCGAGGTGGTGCGGCGAGTCTC
GGGGATCGGGGTGTTCACGATCGTGGGCGGCGGTATCCGGAGCCCGGAGACCGCACGGGAGCTCGCCGAGGCGGGCGCGG
ACGCGATCGTCACCGGGACCGCCGTGGAGCGGGACCCAGACCTGGCCGCGGAGATCGTGGAGGCCATCAAGGACCTTTGA

Upstream 100 bases:

>100_bases
GAAGTGTAACGCGAGGAACCCACCGGACGCCACGAAGTGCAGGAAGTGCGGGTACAAGGGACTACGACCCAAGGCCAGGG
AGCCGAGAGGCGGTTAGACC

Downstream 100 bases:

>100_bases
ACCTGAGGAGCCCGACGAGGTCACGGAGAAAGCGGTCCGGATCGGCCACGCGGAGGCGATGTACTCGCCCGTCGGTCGTC
CGAATCTCGACGACGCTGAC

Product: geranylgeranylglyceryl phosphate synthase-like protein

Products: NA

Alternate protein names: GGGP synthase; GGGPS; (S)-3-O-geranylgeranylglyceryl phosphate synthase; Phosphoglycerol geranylgeranyltransferase

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MGVFGYLRERTPCHLTLLDPVDVGPEEVPEVLESLVKAGTDAVMVGGSTAHASQVEAVVEAIREVADVPVILFPNGPEGL
APNADAVLFMSLLNSRNTYYLIEAQVKGAPLVERFGLESIPTGYLIVGEWGTTVSVVGDARVIPFDRVEVIVAYALAAKH
LGMKAVYLEAGSGAPEPVPPEVVRRVSGIGVFTIVGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKDL

Sequences:

>Translated_239_residues
MGVFGYLRERTPCHLTLLDPVDVGPEEVPEVLESLVKAGTDAVMVGGSTAHASQVEAVVEAIREVADVPVILFPNGPEGL
APNADAVLFMSLLNSRNTYYLIEAQVKGAPLVERFGLESIPTGYLIVGEWGTTVSVVGDARVIPFDRVEVIVAYALAAKH
LGMKAVYLEAGSGAPEPVPPEVVRRVSGIGVFTIVGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKDL
>Mature_238_residues
GVFGYLRERTPCHLTLLDPVDVGPEEVPEVLESLVKAGTDAVMVGGSTAHASQVEAVVEAIREVADVPVILFPNGPEGLA
PNADAVLFMSLLNSRNTYYLIEAQVKGAPLVERFGLESIPTGYLIVGEWGTTVSVVGDARVIPFDRVEVIVAYALAAKHL
GMKAVYLEAGSGAPEPVPPEVVRRVSGIGVFTIVGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKDL

Specific function: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membr

COG id: COG1646

COG function: function code R; Predicted phosphate-binding enzymes, TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GGGP synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GGGPS_METKA (Q8TXM0)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613927.1
- ProteinModelPortal:   Q8TXM0
- SMR:   Q8TXM0
- GeneID:   1476743
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0642
- NMPDR:   fig|190192.1.peg.640
- HOGENOM:   HBG313841
- OMA:   ADAIFFM
- ProtClustDB:   PRK04169
- BioCyc:   MKAN190192:MK0642-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00112
- InterPro:   IPR008205
- InterPro:   IPR010946
- Gene3D:   G3DSA:3.20.20.390
- TIGRFAMs:   TIGR01769
- TIGRFAMs:   TIGR01768

Pfam domain/function: PF01884 PcrB

EC number: =2.5.1.41

Molecular weight: Translated: 25052; Mature: 24921

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: NA

Important sites: BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVFGYLRERTPCHLTLLDPVDVGPEEVPEVLESLVKAGTDAVMVGGSTAHASQVEAVVE
CCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AIREVADVPVILFPNGPEGLAPNADAVLFMSLLNSRNTYYLIEAQVKGAPLVERFGLESI
HHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCCC
PTGYLIVGEWGTTVSVVGDARVIPFDRVEVIVAYALAAKHLGMKAVYLEAGSGAPEPVPP
CCCEEEEECCCCEEEEECCCEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCH
EVVRRVSGIGVFTIVGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKDL
HHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GVFGYLRERTPCHLTLLDPVDVGPEEVPEVLESLVKAGTDAVMVGGSTAHASQVEAVVE
CCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AIREVADVPVILFPNGPEGLAPNADAVLFMSLLNSRNTYYLIEAQVKGAPLVERFGLESI
HHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCCC
PTGYLIVGEWGTTVSVVGDARVIPFDRVEVIVAYALAAKHLGMKAVYLEAGSGAPEPVPP
CCCEEEEECCCCEEEEECCCEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCH
EVVRRVSGIGVFTIVGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKDL
HHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014