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The map label for this gene is PyrC

Identifier: 20093968

GI number: 20093968

Start: 493786

End: 495066

Strand: Direct

Name: PyrC

Synonym: MK0530

Alternate gene names: 20093968

Gene position: 493786-495066 (Clockwise)

Preceding gene: 20093967

Following gene: 20093969

Centisome position: 29.13

GC content: 60.11

Gene sequence:

>1281_bases
GTGTTAGCGTTGCGGGTGCTGCTCAAGGGCAAGATCCTGATCGGAGGGCGGGTACGAGAGCGCGAGGTGCTGGCCGAAGA
CGGTTGGATAGTCAAGATCGGCAAGAGACTGAACGAAGAGGCCGACCTCACGCTGGAATTGGGAAAAAGGGAGCTAGCGG
TCCCGGCCCCGATCGACCTGCACGTGCATTGCCGGGATCCGCACCCGGATTACCCGTTTGGGTTCAAAACCGAAACAAGA
AGGTTTCTTTTAGGAGGAGTCGCTACCGTAGTGGACATGCCGAACACGCGTCCGGCTCCCACTACACCTGAAACGTACTA
CGAAAAGGAGGAACTGGCGCGGGAGAACGCCGAGATCGAGGTCATCGTGGCCGGAGGCGTGAGGGATTCTCAGTGCACCA
AGGAACTCGTCGAAGCCGGAGCGTACGTGCTCGGGGAAGTGTTCCTAGCGACGTCCACCGACGCGCCCGCGGTGCCGTGG
AGCACGCTTCCGGAAATCTTCAGGGAACTATCCCCTGATGGTCCTCTAACGATATTCCATCCCGAGCTCGACGAACTGGT
GGCCGAGAGGCCGGCCCGAAACCTCTACGAGCACCTAAAAAATAGGCCGCCGGAGGCTGAAACAACCGCCGTAGGGCTCC
TGGCCGGGCTCAAGGTAAGATACCCAAGCCGTATCCATTTGTCTCACGTCACGCTGCCCGAGTCGGTGAAGATCGCCAAA
GGAGCGGACATTACCGTGGACGTGACTCCCCACCACCTCTTCTTCGACGTGCTGCGAGTGGACCCGGAGGACCCTGTGTT
TAAAGTGAACCCTCCACTGCGAGGTCGTCATCACAGACTCGGACTCCTGCGCGCTGTGAGGAGAGGGGACGTGGACGTAC
TCGCCTCCGATCATGCCCCGCACATCCTCGAGGACGAGTTCGAGGACGTCCCATCAGGAGTCACTGGAGGGGAGATCATC
CTACCGGCGGCCCTCACGTTACACAGGCGATTCGGTTTGTCACTGAGGGACGCTGTGGCCATGATCACGTGCCGACCGGC
GAAGCTCCTAGGCCGCGACGATCTAGGTGAGGTAGCGGTGGGGAAACGTGCCAGAATAACGGTCGTTCGAATGCGGGAGT
TCGTCGTCCGGGCCGAGGAGTTCGGAGAGGAAGATCGGAAATTCCCCTACGACGGTATGCGGATGTTCGGAGAGCCCGTC
AAGTTGATCGACGGGACCAAGGTGTACGACCTCAAGGAATCTCGGCGGGAGGGGAAGCCGGTCATACTGGAGGGTGAGTG
A

Upstream 100 bases:

>100_bases
CGTGTTCGAGGACCTTGCTGAATGCACACGTGGTCGTGCGGGAGCCACGTGAAGCCTTGGAGCTACTCCTCGATCCGAAA
GCGCTCAGGGCGACGATGAG

Downstream 100 bases:

>100_bases
GTTGCCCACGGGTGCCAGGGTACTCGTCGAGTGCTTGAAAGAAGAGGGCGTCGAGCACATTTTCGGGTACCCGGGAGGTG
CCGTCCTACCGATTTATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDLHVHCRDPHPDYPFGFKTETR
RFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIEVIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPW
STLPEIFRELSPDGPLTIFHPELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAK
GADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAPHILEDEFEDVPSGVTGGEII
LPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAVGKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPV
KLIDGTKVYDLKESRREGKPVILEGE

Sequences:

>Translated_426_residues
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDLHVHCRDPHPDYPFGFKTETR
RFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIEVIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPW
STLPEIFRELSPDGPLTIFHPELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAK
GADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAPHILEDEFEDVPSGVTGGEII
LPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAVGKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPV
KLIDGTKVYDLKESRREGKPVILEGE
>Mature_426_residues
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDLHVHCRDPHPDYPFGFKTETR
RFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIEVIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPW
STLPEIFRELSPDGPLTIFHPELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAK
GADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAPHILEDEFEDVPSGVTGGEII
LPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAVGKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPV
KLIDGTKVYDLKESRREGKPVILEGE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=315, Percent_Identity=27.3015873015873, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786722, Length=451, Percent_Identity=23.5033259423503, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=329, Percent_Identity=24.6200607902736, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=392, Percent_Identity=26.2755102040816, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24642586, Length=361, Percent_Identity=27.1468144044321, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859883, Length=404, Percent_Identity=27.4752475247525, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_METKA (Q8TXX9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613815.1
- ProteinModelPortal:   Q8TXX9
- GeneID:   1476631
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0530
- NMPDR:   fig|190192.1.peg.528
- OMA:   LLAHCEH
- BioCyc:   MKAN190192:MK0530-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_A
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 47525; Mature: 47525

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDL
CEEEEEEECCCEEECCCCCHHHHHHCCCEEEEECHHCCCCCCEEEEECCCEECCCCCCEE
HVHCRDPHPDYPFGFKTETRRFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIE
EEEECCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCCCCEE
VIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPWSTLPEIFRELSPDGPLTIFH
EEEECCCCCHHHHHHHHHHCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEC
PELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAK
CCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCEECCCCEEEEEEECCCCCEEEEC
GADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAP
CCEEEEECCCHHHEEHHHEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCCC
HILEDEFEDVPSGVTGGEIILPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAV
CHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHEEEEEECCHHHCCCCCCCCHHC
GKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPVKLIDGTKVYDLKESRREGKP
CCCCEEEHHHHHHHHHHHHHHCCHHCCCCCHHHHHCCCCEEEECCCEEEECHHHHHCCCC
VILEGE
EEEECC
>Mature Secondary Structure
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDL
CEEEEEEECCCEEECCCCCHHHHHHCCCEEEEECHHCCCCCCEEEEECCCEECCCCCCEE
HVHCRDPHPDYPFGFKTETRRFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIE
EEEECCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCCCCEE
VIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPWSTLPEIFRELSPDGPLTIFH
EEEECCCCCHHHHHHHHHHCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEC
PELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAK
CCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCEECCCCEEEEEEECCCCCEEEEC
GADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAP
CCEEEEECCCHHHEEHHHEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCCC
HILEDEFEDVPSGVTGGEIILPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAV
CHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHEEEEEECCHHHCCCCCCCCHHC
GKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPVKLIDGTKVYDLKESRREGKP
CCCCEEEHHHHHHHHHHHHHHCCHHCCCCCHHHHHCCCCEEEECCCEEEECHHHHHCCCC
VILEGE
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014