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The map label for this gene is NadC [H]

Identifier: 20093884

GI number: 20093884

Start: 416913

End: 417761

Strand: Direct

Name: NadC [H]

Synonym: MK0446

Alternate gene names: 20093884

Gene position: 416913-417761 (Clockwise)

Preceding gene: 20093883

Following gene: 20093887

Centisome position: 24.6

GC content: 61.96

Gene sequence:

>849_bases
GTGCTCCTGAACGAGGTTAAGGTTCGGAAGATCGTGGAGCTAGCACTGACGGAAGACGTCGGCCGTGCGGATCTGACCTC
CTCCATTGTGGAAGGTGAGCGGGCGGAGGCGGAGATCGTGGCAAAAGAGGAGGGCGTCGTTTCGGGAACGCTCCCGGCCC
GACTGACGTTCGAACTCCTAGACTGCGAAGTCGACGTGCTCGTGGAAGACGGCGAACGAATTCAACCCGGCGACATCGTG
CTGAAAGCCTATGGGGAGGCTACGGCCCTTCTCGCGGCGGAGCGAGTGGCGCTCAACTTCCTCATGCGGCTGTCCGGGAT
CGCGACGGCTACGCGGAAGGTCGTCGAGAGAGTCCGTGAGGTGAATCCGGACGTTATTGTAGCCGCGACCAGGAAAGTCC
ATCCGATCACGGGATTTCTCGAGAAGAAGGCGGTATCGGATGGGGGCGGAGACCTCCACCGGTTCGGCCTGGACGATGCC
GTTCTGATCAAAGATAACCACCTGGCGCTGGTCGGGTCGGTCCGGGATGCCGTGCGGCGGGCGAGGGAGCGGGTGGGTTT
CACCAAAGTAATCGGCGTGGAAGTCGAGTCGATCGAAGACGCCGTTGAGGCCGCGAAGGCGGGCGCGGACCACGTGTTGC
TGGATAATATGAAACCGGCGGAGATCCGGCGGGCGGTGAACGAAGTTCGGAAAGTCCGTGAAGATGTGATCCTGGAGGCT
TCCGGTGGCATCACGCCCGAGAACGCACCCGAGTACGCGGAAACCGGAGTTGATGTGATCTCGCTCGGGTGGTTGACACA
CTCCGCGCCGGCCTTGGACCTGAGCATGCGGGTTCGACGGATGACATGA

Upstream 100 bases:

>100_bases
TGCCGAAAGTACAATCGTGGAGGTTTAGATCCACACCGACGTCGAGTGACGCTGTGCATTTGATCCCTCCCATCCGTCGT
TACGATAGGGGCGGTCGGTC

Downstream 100 bases:

>100_bases
AGAGTGTCGGGATATCCTCACTTCCGAGACCGGTACTCGAGCTCGCGGACGAAATCGCTCAAGGTCATCACGAACCGGGC
GTCGGCGACGCGGTGAGCGT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLLNEVKVRKIVELALTEDVGRADLTSSIVEGERAEAEIVAKEEGVVSGTLPARLTFELLDCEVDVLVEDGERIQPGDIV
LKAYGEATALLAAERVALNFLMRLSGIATATRKVVERVREVNPDVIVAATRKVHPITGFLEKKAVSDGGGDLHRFGLDDA
VLIKDNHLALVGSVRDAVRRARERVGFTKVIGVEVESIEDAVEAAKAGADHVLLDNMKPAEIRRAVNEVRKVREDVILEA
SGGITPENAPEYAETGVDVISLGWLTHSAPALDLSMRVRRMT

Sequences:

>Translated_282_residues
MLLNEVKVRKIVELALTEDVGRADLTSSIVEGERAEAEIVAKEEGVVSGTLPARLTFELLDCEVDVLVEDGERIQPGDIV
LKAYGEATALLAAERVALNFLMRLSGIATATRKVVERVREVNPDVIVAATRKVHPITGFLEKKAVSDGGGDLHRFGLDDA
VLIKDNHLALVGSVRDAVRRARERVGFTKVIGVEVESIEDAVEAAKAGADHVLLDNMKPAEIRRAVNEVRKVREDVILEA
SGGITPENAPEYAETGVDVISLGWLTHSAPALDLSMRVRRMT
>Mature_282_residues
MLLNEVKVRKIVELALTEDVGRADLTSSIVEGERAEAEIVAKEEGVVSGTLPARLTFELLDCEVDVLVEDGERIQPGDIV
LKAYGEATALLAAERVALNFLMRLSGIATATRKVVERVREVNPDVIVAATRKVHPITGFLEKKAVSDGGGDLHRFGLDDA
VLIKDNHLALVGSVRDAVRRARERVGFTKVIGVEVESIEDAVEAAKAGADHVLLDNMKPAEIRRAVNEVRKVREDVILEA
SGGITPENAPEYAETGVDVISLGWLTHSAPALDLSMRVRRMT

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=38.8489208633094, Blast_Score=171, Evalue=5e-43,
Organism=Escherichia coli, GI1786299, Length=277, Percent_Identity=39.7111913357401, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=34.0501792114695, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30553; Mature: 30553

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNEVKVRKIVELALTEDVGRADLTSSIVEGERAEAEIVAKEEGVVSGTLPARLTFELL
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCHHEEEEEE
DCEVDVLVEDGERIQPGDIVLKAYGEATALLAAERVALNFLMRLSGIATATRKVVERVRE
CCEEEEEECCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPDVIVAATRKVHPITGFLEKKAVSDGGGDLHRFGLDDAVLIKDNHLALVGSVRDAVRR
CCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCEEEEHHHHHHHHH
ARERVGFTKVIGVEVESIEDAVEAAKAGADHVLLDNMKPAEIRRAVNEVRKVREDVILEA
HHHHCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHEEEEC
SGGITPENAPEYAETGVDVISLGWLTHSAPALDLSMRVRRMT
CCCCCCCCCCCHHHCCCCEEEECCHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MLLNEVKVRKIVELALTEDVGRADLTSSIVEGERAEAEIVAKEEGVVSGTLPARLTFELL
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCHHEEEEEE
DCEVDVLVEDGERIQPGDIVLKAYGEATALLAAERVALNFLMRLSGIATATRKVVERVRE
CCEEEEEECCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPDVIVAATRKVHPITGFLEKKAVSDGGGDLHRFGLDDAVLIKDNHLALVGSVRDAVRR
CCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCEEEEHHHHHHHHH
ARERVGFTKVIGVEVESIEDAVEAAKAGADHVLLDNMKPAEIRRAVNEVRKVREDVILEA
HHHHCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHEEEEC
SGGITPENAPEYAETGVDVISLGWLTHSAPALDLSMRVRRMT
CCCCCCCCCCCHHHCCCCEEEECCHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]