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The map label for this gene is AroD

Identifier: 20093867

GI number: 20093867

Start: 402699

End: 403346

Strand: Direct

Name: AroD

Synonym: MK0429

Alternate gene names: 20093867

Gene position: 402699-403346 (Clockwise)

Preceding gene: 20093866

Following gene: 20093878

Centisome position: 23.76

GC content: 57.56

Gene sequence:

>648_bases
TTGATCATCGCCACTCTTACAGGCAGAACCATCGAGGATATGGTGGAACTGGCTATAGAAGCCGTAGAGCAGGGTGCGGA
CGCTCTGGAGGTCAGGCTCGATTACTTGGAGAACTTAGACATGTCGACGGCGCTCAGAGCCGTGCGAGAGTGTACTAGGT
ACGAACGCGTAGTGGCGACGCTCCGACGCGAAGAGGAGGGAGGACTGTACAAAGGCGATGAAGATCGGAGGCTCGAAATC
CTGGAGCGGGTGTCCTCCGAGGCCGACTACGTGGACTTGGAGCTCGACGTAGCGGAGGAAGAGATCATAAGCCCGTCCTG
TGAGACGATCGTGTCGTACCACAACTTCGAAAATACGCCGCCTAAGGAGGAGCTGATCGGCATCAGGGACCGGTGCGCCG
AATTAGGAGACGTTGCGAAGGTCGTCACTATGGCCAGGGGACACGAAGACGCACTGCGGATCCTGGAAGTAGTACGAACG
GCAGAAGCACCCACTATAGGATTCGCGATGGGAGAGGAGGCCAAGTACACCAGGGTAGTGAGTGTTCTGATCGGCGGGTT
CGCGACTTACGCCGCTGTGAGGAAGAAAGCGGCACCAGGGCAGCTGACGGTCGAGGAGACACGCAAGTTGCTGGAACTAC
TCGGTTAG

Upstream 100 bases:

>100_bases
ATAGTGTACGCGGAGCCGCTCGGGGCTGATCCCAGAATCGCCGAGATAGTCATCGATAGGATCAAAGAGGCGCTAGGCGA
GGAATAACCGGGGCCTCCGC

Downstream 100 bases:

>100_bases
CCGCTCGAGGATCTCCTCCGCCGCTTTCTTCCCTGACTCGAGCATCCCGCCGAAGATGGGCCCCATCCTGTACGCGCCTT
TCACCGCCGACGCTGCCATG

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVATLRREEEGGLYKGDEDRRLEI
LERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTPPKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRT
AEAPTIGFAMGEEAKYTRVVSVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG

Sequences:

>Translated_215_residues
MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVATLRREEEGGLYKGDEDRRLEI
LERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTPPKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRT
AEAPTIGFAMGEEAKYTRVVSVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG
>Mature_215_residues
MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVATLRREEEGGLYKGDEDRRLEI
LERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTPPKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRT
AEAPTIGFAMGEEAKYTRVVSVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=233, Percent_Identity=26.1802575107296, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_METKA (Q8TY76)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613714.1
- ProteinModelPortal:   Q8TY76
- SMR:   Q8TY76
- GeneID:   1477732
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0429
- NMPDR:   fig|190192.1.peg.427
- HOGENOM:   HBG732926
- OMA:   IAKLAVM
- BioCyc:   MKAN190192:MK0429-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 23920; Mature: 23920

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 114-114 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVAT
CEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LRREEEGGLYKGDEDRRLEILERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTP
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCHHHHHHHHHCCCCCC
PKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRTAEAPTIGFAMGEEAKYTRVV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHH
SVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
>Mature Secondary Structure
MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVAT
CEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LRREEEGGLYKGDEDRRLEILERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTP
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCHHHHHHHHHCCCCCC
PKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRTAEAPTIGFAMGEEAKYTRVV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHH
SVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014