Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 18311212

GI number: 18311212

Start: 2551428

End: 2552807

Strand: Reverse

Name: htrA [H]

Synonym: CPE2230

Alternate gene names: 18311212

Gene position: 2552807-2551428 (Counterclockwise)

Preceding gene: 18311213

Following gene: 18311211

Centisome position: 84.21

GC content: 30.65

Gene sequence:

>1380_bases
ATGAGTGATTTCAATAAAAAAGATGAAAATTTAAATGACTACTTTGGTTTTGATGATAAAGAAAATAAAACTTTAGATTC
AGATAAGGACATAAAAGACAAAGAAAATATAGAATCAAATAATGATACGAAGCAAACTAACATAGATGAAACTCAGCAAT
TAAATATAGATAATGAAATTAATTCGAAAGATGAAGTTAAAAAAGATGATGATAAAAACTTCTCTGACGTAAAATCAAAA
AGCTCAAAAGAATCTAATGACAATAGTAAAAACAAAAAAGTAAAGAAAAAGAGTGGATTTAAAAGAGGAATAGCTCTAGT
AGCAGGTGCTGTCATAGTTGCTATATTAGGAGGAGCTATAGGTGCTGGCGGAGTTTATTATGCTTTTAAAAATAGCATAC
CAGTAAGTACACTAGAGAATAATAGTAATACCTCAGTTAATCCACCAGCCTTTAAAGGGGAAGATGGAGCATTAACTGTT
CCACAAGTAGTTGAAAAAGTTACACCTGCCGTTGTAGGAGTATCTACAAAGAGCTTAGTAAGAGACCAATTCTTTAATGT
AAAAGAACAAGAAGGATTAGGTTCTGGATTTATAATAAATGAAGATGGATATGTAGTTACAAACTACCATGTTATAAATG
GAGCTCAAGAAGTTAAAGTAATATTCTCTGATGGAAAAGAAGTAAATGCTAAGGTTGTAAATTACGATGCAGAAAGAGAT
ATTGCAGTAATAAAAATAACAGACGATGTTAAAATGCCTGGAATAGCACAATTAGGAGATTCATCTACAGTTAAAGCTGG
TGAAGAAGTAATTGCTATAGGAAATCCTCTAGGAAAAGAATTTAGTTCAACAGTAACTAAAGGAATAGTAAGTTCACCAA
ATAGAAAGATGAAGACTGAAAACGGAAATGTATTAGATTATATACAAACAGATGCAGCTATTAACCCTGGTAACAGTGGG
GGGCCATTAATAAACTCTAAGGGAGAAGTTATTGGAATAAACACTGCTAAAAAAGTTGGTGAAGATATTGAAGGTATAGG
ATTTGCAATTCCTATAAATGAAGTTAAAACAAGATTAGGTTCATTATCAAAACCAATATTAAAACTTGGTATTACAGCTA
GAACTGTTACTCCAGAATTAGCAAAAGAAAATAAGCTAGAAGAAGGAGTTTATGTTGTAGGAGTACAAGAGTTTAGTCCA
GCAGAAAAAGCAGGATTAAAAATAGGTGACTTAATAGTTGAATTTGGTGGGAAAAGAGTAAAAACTTTAGAAGAATTAAA
TCAAGTTAAAAGTCAATATAATGATGGAGATTCAGTACCAGTTGAAATAATTAGAGATGGTAAGAAAGTAAACTTAAATT
TAACATTAGTTGCTAATTAG

Upstream 100 bases:

>100_bases
TATCCTATGACATAGAAATGACATAAACATGACATATAAATGACACAAAAAATGGTTATTATAAACATGTGGAAAACAAA
TGTTTAGGAGGGTATGAACA

Downstream 100 bases:

>100_bases
TTTAATAAAGGATGTATATCAAATAAATTTTATTACCTTGATATATGTCCTTTTTTATTTTAAACAAAAAATAAATGTAA
AATTTTAGATAAAAATGAAA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSDFNKKDENLNDYFGFDDKENKTLDSDKDIKDKENIESNNDTKQTNIDETQQLNIDNEINSKDEVKKDDDKNFSDVKSK
SSKESNDNSKNKKVKKKSGFKRGIALVAGAVIVAILGGAIGAGGVYYAFKNSIPVSTLENNSNTSVNPPAFKGEDGALTV
PQVVEKVTPAVVGVSTKSLVRDQFFNVKEQEGLGSGFIINEDGYVVTNYHVINGAQEVKVIFSDGKEVNAKVVNYDAERD
IAVIKITDDVKMPGIAQLGDSSTVKAGEEVIAIGNPLGKEFSSTVTKGIVSSPNRKMKTENGNVLDYIQTDAAINPGNSG
GPLINSKGEVIGINTAKKVGEDIEGIGFAIPINEVKTRLGSLSKPILKLGITARTVTPELAKENKLEEGVYVVGVQEFSP
AEKAGLKIGDLIVEFGGKRVKTLEELNQVKSQYNDGDSVPVEIIRDGKKVNLNLTLVAN

Sequences:

>Translated_459_residues
MSDFNKKDENLNDYFGFDDKENKTLDSDKDIKDKENIESNNDTKQTNIDETQQLNIDNEINSKDEVKKDDDKNFSDVKSK
SSKESNDNSKNKKVKKKSGFKRGIALVAGAVIVAILGGAIGAGGVYYAFKNSIPVSTLENNSNTSVNPPAFKGEDGALTV
PQVVEKVTPAVVGVSTKSLVRDQFFNVKEQEGLGSGFIINEDGYVVTNYHVINGAQEVKVIFSDGKEVNAKVVNYDAERD
IAVIKITDDVKMPGIAQLGDSSTVKAGEEVIAIGNPLGKEFSSTVTKGIVSSPNRKMKTENGNVLDYIQTDAAINPGNSG
GPLINSKGEVIGINTAKKVGEDIEGIGFAIPINEVKTRLGSLSKPILKLGITARTVTPELAKENKLEEGVYVVGVQEFSP
AEKAGLKIGDLIVEFGGKRVKTLEELNQVKSQYNDGDSVPVEIIRDGKKVNLNLTLVAN
>Mature_458_residues
SDFNKKDENLNDYFGFDDKENKTLDSDKDIKDKENIESNNDTKQTNIDETQQLNIDNEINSKDEVKKDDDKNFSDVKSKS
SKESNDNSKNKKVKKKSGFKRGIALVAGAVIVAILGGAIGAGGVYYAFKNSIPVSTLENNSNTSVNPPAFKGEDGALTVP
QVVEKVTPAVVGVSTKSLVRDQFFNVKEQEGLGSGFIINEDGYVVTNYHVINGAQEVKVIFSDGKEVNAKVVNYDAERDI
AVIKITDDVKMPGIAQLGDSSTVKAGEEVIAIGNPLGKEFSSTVTKGIVSSPNRKMKTENGNVLDYIQTDAAINPGNSGG
PLINSKGEVIGINTAKKVGEDIEGIGFAIPINEVKTRLGSLSKPILKLGITARTVTPELAKENKLEEGVYVVGVQEFSPA
EKAGLKIGDLIVEFGGKRVKTLEELNQVKSQYNDGDSVPVEIIRDGKKVNLNLTLVAN

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=289, Percent_Identity=39.1003460207612, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4506141, Length=288, Percent_Identity=40.9722222222222, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI24308541, Length=319, Percent_Identity=36.6771159874608, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI7019477, Length=318, Percent_Identity=36.1635220125786, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786356, Length=276, Percent_Identity=43.1159420289855, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789629, Length=324, Percent_Identity=37.3456790123457, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789630, Length=304, Percent_Identity=35.8552631578947, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=35.9861591695502, Blast_Score=145, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49432; Mature: 49301

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFNKKDENLNDYFGFDDKENKTLDSDKDIKDKENIESNNDTKQTNIDETQQLNIDNEI
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHEECCCCCC
NSKDEVKKDDDKNFSDVKSKSSKESNDNSKNKKVKKKSGFKRGIALVAGAVIVAILGGAI
CCCHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GAGGVYYAFKNSIPVSTLENNSNTSVNPPAFKGEDGALTVPQVVEKVTPAVVGVSTKSLV
CCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCHHEECCHHHHH
RDQFFNVKEQEGLGSGFIINEDGYVVTNYHVINGAQEVKVIFSDGKEVNAKVVNYDAERD
HHHHCCCHHHCCCCCCEEECCCCEEEEEEEEECCCCEEEEEEECCCCCCEEEEEECCCCC
IAVIKITDDVKMPGIAQLGDSSTVKAGEEVIAIGNPLGKEFSSTVTKGIVSSPNRKMKTE
EEEEEEECCCCCCCHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEECC
NGNVLDYIQTDAAINPGNSGGPLINSKGEVIGINTAKKVGEDIEGIGFAIPINEVKTRLG
CCCEEEEEECCCEECCCCCCCCEECCCCCEEECCCHHHHCCCCCCCEEEEEHHHHHHHHH
SLSKPILKLGITARTVTPELAKENKLEEGVYVVGVQEFSPAEKAGLKIGDLIVEFGGKRV
HHHCCHHHHCCEEEECCHHHHHHCCCCCCEEEEEECCCCCHHHHCCCHHHHHHHCCCCHH
KTLEELNQVKSQYNDGDSVPVEIIRDGKKVNLNLTLVAN
HHHHHHHHHHHHCCCCCCCCHHEECCCCEEEEEEEEEEC
>Mature Secondary Structure 
SDFNKKDENLNDYFGFDDKENKTLDSDKDIKDKENIESNNDTKQTNIDETQQLNIDNEI
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHEECCCCCC
NSKDEVKKDDDKNFSDVKSKSSKESNDNSKNKKVKKKSGFKRGIALVAGAVIVAILGGAI
CCCHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GAGGVYYAFKNSIPVSTLENNSNTSVNPPAFKGEDGALTVPQVVEKVTPAVVGVSTKSLV
CCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCHHEECCHHHHH
RDQFFNVKEQEGLGSGFIINEDGYVVTNYHVINGAQEVKVIFSDGKEVNAKVVNYDAERD
HHHHCCCHHHCCCCCCEEECCCCEEEEEEEEECCCCEEEEEEECCCCCCEEEEEECCCCC
IAVIKITDDVKMPGIAQLGDSSTVKAGEEVIAIGNPLGKEFSSTVTKGIVSSPNRKMKTE
EEEEEEECCCCCCCHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEECC
NGNVLDYIQTDAAINPGNSGGPLINSKGEVIGINTAKKVGEDIEGIGFAIPINEVKTRLG
CCCEEEEEECCCEECCCCCCCCEECCCCCEEECCCHHHHCCCCCCCEEEEEHHHHHHHHH
SLSKPILKLGITARTVTPELAKENKLEEGVYVVGVQEFSPAEKAGLKIGDLIVEFGGKRV
HHHCCHHHHCCEEEECCHHHHHHCCCCCCEEEEEECCCCCHHHHCCCHHHHHHHCCCCHH
KTLEELNQVKSQYNDGDSVPVEIIRDGKKVNLNLTLVAN
HHHHHHHHHHHHCCCCCCCCHHEECCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9829922 [H]