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The map label for this gene is mscS [H]

Identifier: 17547381

GI number: 17547381

Start: 2871591

End: 2872487

Strand: Direct

Name: mscS [H]

Synonym: RSc2662

Alternate gene names: 17547381

Gene position: 2871591-2872487 (Clockwise)

Preceding gene: 17547379

Following gene: 17547383

Centisome position: 77.27

GC content: 65.44

Gene sequence:

>897_bases
ATGGCTGAAAACTTGATGGACACCACCGTCAACACGGCAAGCAAGTACCAGGCAATCGTGGCGCAGTACGCCACCGATGT
CGGAATGAAGATCCTGGCGGCGATCGCCTTCTGGGTCATCGGCCGCTGGCTGATCCACCTGGCGGTGCGGCTGGTGCAGG
GTTCGCTGGAACACCAGAAGGTGGACCCGACCGTGCTGCGCTATGTCGGCTCGGTCATCACCGTCACGCTGAACATCCTG
CTGGTGATCGGCATCCTGGGCTACTTCGGCATCCAGACCACGACGTTCGCGGCGCTGATCGCGGCGGCGGGCGTGGCGAT
CGGCATGGCGTGGTCGGGGCTGCTGTCCAACTTCGCGGCCGGGGCGTTCCTGATCGTGCTGCGGCCGTTCAAGGTGGGCG
ATTTCGTCACGGTCGCCGGCGTGACCGGCACGGTCAAGGAAATCGGCCTGTTCGCCACTGCGCTCAATACGCCGGACAAC
GTCGTCACGCTGGTCGGCAACAACAAGATCTTCTCGGACACGATCCAGAACTACACGAGCAACCCCTACCGCCGCGTCGA
GCTCAAGGCGCAGCTGGCCGGCAATGCCGACCACCGCGCCGCCATCGCGCTGCTCAAGGAGAAGGTCGGGGCGATCCCGA
ACGTGCTGGCGGATCCGCCGGTCGACGTGGAGATCCTGGAATTCAACCTGGTGGGGCCGGTGCTGGCGGTGCGCCCGCAC
ACGCACAACGACCACTACTGGCAGGTCTACTTCGACACCAACCGCACGATCAAGGAAGCGCTGGCCGAAGCAGGCTTCCC
GGTGCCGACGCCATCGCAGGCGCTGTCGGTGACCATGCCGGCCACGCTGCAGGGGCTGACGGCGGTGGCGCAGGGCCACT
CCGTGAGCGTGAACTGA

Upstream 100 bases:

>100_bases
CGTCAAAGCTAAAAAATGTGGAAAGAAGGTGCCAAAGTCACACAACCGTGGTCGCATTGCCTATCGTTGAAACGTTCTGT
CGACTGCCCCGGAGCACACC

Downstream 100 bases:

>100_bases
AGCGCGCGGCAGCGCAGCAAAACGGCCCGGCGGGAGACTGCCGGGCCGTTTTGCTTGTAGCGGGCCGACCGCCCTATACG
GGCTTGTGCCGCTCATGCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAENLMDTTVNTASKYQAIVAQYATDVGMKILAAIAFWVIGRWLIHLAVRLVQGSLEHQKVDPTVLRYVGSVITVTLNIL
LVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLLSNFAAGAFLIVLRPFKVGDFVTVAGVTGTVKEIGLFATALNTPDN
VVTLVGNNKIFSDTIQNYTSNPYRRVELKAQLAGNADHRAAIALLKEKVGAIPNVLADPPVDVEILEFNLVGPVLAVRPH
THNDHYWQVYFDTNRTIKEALAEAGFPVPTPSQALSVTMPATLQGLTAVAQGHSVSVN

Sequences:

>Translated_298_residues
MAENLMDTTVNTASKYQAIVAQYATDVGMKILAAIAFWVIGRWLIHLAVRLVQGSLEHQKVDPTVLRYVGSVITVTLNIL
LVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLLSNFAAGAFLIVLRPFKVGDFVTVAGVTGTVKEIGLFATALNTPDN
VVTLVGNNKIFSDTIQNYTSNPYRRVELKAQLAGNADHRAAIALLKEKVGAIPNVLADPPVDVEILEFNLVGPVLAVRPH
THNDHYWQVYFDTNRTIKEALAEAGFPVPTPSQALSVTMPATLQGLTAVAQGHSVSVN
>Mature_297_residues
AENLMDTTVNTASKYQAIVAQYATDVGMKILAAIAFWVIGRWLIHLAVRLVQGSLEHQKVDPTVLRYVGSVITVTLNILL
VIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLLSNFAAGAFLIVLRPFKVGDFVTVAGVTGTVKEIGLFATALNTPDNV
VTLVGNNKIFSDTIQNYTSNPYRRVELKAQLAGNADHRAAIALLKEKVGAIPNVLADPPVDVEILEFNLVGPVLAVRPHT
HNDHYWQVYFDTNRTIKEALAEAGFPVPTPSQALSVTMPATLQGLTAVAQGHSVSVN

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=272, Percent_Identity=29.4117647058824, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1787591, Length=142, Percent_Identity=30.9859154929577, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 31845; Mature: 31714

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENLMDTTVNTASKYQAIVAQYATDVGMKILAAIAFWVIGRWLIHLAVRLVQGSLEHQK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
VDPTVLRYVGSVITVTLNILLVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLLSNFAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAFLIVLRPFKVGDFVTVAGVTGTVKEIGLFATALNTPDNVVTLVGNNKIFSDTIQNYTS
CEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCC
NPYRRVELKAQLAGNADHRAAIALLKEKVGAIPNVLADPPVDVEILEFNLVGPVLAVRPH
CCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEEEEECCEEEECCC
THNDHYWQVYFDTNRTIKEALAEAGFPVPTPSQALSVTMPATLQGLTAVAQGHSVSVN
CCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
AENLMDTTVNTASKYQAIVAQYATDVGMKILAAIAFWVIGRWLIHLAVRLVQGSLEHQK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
VDPTVLRYVGSVITVTLNILLVIGILGYFGIQTTTFAALIAAAGVAIGMAWSGLLSNFAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAFLIVLRPFKVGDFVTVAGVTGTVKEIGLFATALNTPDNVVTLVGNNKIFSDTIQNYTS
CEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCC
NPYRRVELKAQLAGNADHRAAIALLKEKVGAIPNVLADPPVDVEILEFNLVGPVLAVRPH
CCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEEEEECCEEEECCC
THNDHYWQVYFDTNRTIKEALAEAGFPVPTPSQALSVTMPATLQGLTAVAQGHSVSVN
CCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]