Click here to switch to the map view.

The map label for this gene is dld [H]

Identifier: 17547383

GI number: 17547383

Start: 2873241

End: 2874659

Strand: Direct

Name: dld [H]

Synonym: RSc2664

Alternate gene names: 17547383

Gene position: 2873241-2874659 (Clockwise)

Preceding gene: 17547381

Following gene: 17547384

Centisome position: 77.31

GC content: 69.27

Gene sequence:

>1419_bases
ATGAACCACCCCCTGCCCCATCCCGGATTGGCGCGCAAGCCCATCCCGCCGGCCATGCTCGATGCGCTGCGCGCGCGCTT
CGGCGACCGAGTCTCCACCAGCGATGCCGTGCGCGCGCATCACGGCCGCGACGAATCGGCCTACGATCCGATGCTGCCCG
ACGCCGTGGTCTTCGCGCAGACCACCGAGGACGTGGTGGCGGTGGCCAGGCTCTGCCACGAACACGCCATCCCGCTGATC
CCGTTCGGCGCCGGCTCGTCGCTGGAAGGCCACTTGCTGGCGGTGGCGGGCGGCGTCACGCTGGATCTCTCGCAGATGAA
CCGCGTGCTGTCGGTGCACCCCGAAGACCTGACGGTGACGGTCGAGCCGGGCGTCACGCGCAAGCAGCTGAACGCGGACA
TCCGCGACACCGGCCTGTTCTTCCCGATCGACCCGGGCGCCGATGCGTCCATCGGCGGCATGTGCGCGACGCGCGCCTCG
GGCACCAACGCCGTGCGCTACGGCACCATGCGCGAAAACGTGCTGAACCTGACCGTGGTGACCGCCGACGGCCGCGTCAT
CAAGACCGCGAACCGCGCGCGCAAATCGTCGGCGGGCTACGACCTGACGCGCCTGTTCATCGGCAGCGAGGGAACGCTGG
GCATCATCACCGAGATCACGCTCAGGCTGTATCCGCAGCCGGAGGCGGTGTCGGCGGCGGTGTGCGCGTTCCCCGGCATG
GGCGACGCGGTCTGCGCGGTGATCGACACCATCCAGATGGGCGTGCCGGTGGCGCGCGTGGAGTTCGTCGACGCGCTGGC
GATCCGCGCCATCAACCGATACGACAAGCTGTCGCTGCCCGAGCTGCCGACACTGTTCTTCGAGTTCCACGGCTCCGCGC
ACGGCGTGCAGGAGCAGGCCGAGACCGTGCAGGCGATCGCCGCCGAGCACCGGGGCCAGGGCTTCGAATGGGCCACCCGC
CCCGAAGACCGCAGCCGCCTGTGGAACGCCCGGCACAACGCCTATTTCGCCTTCCTGCAGCTCAAGCCCGGCTGCCGCGC
GGTCACCACCGACGTGTGCGTGCCGATCTCGCGGCTGGCCGATTGCGTGGTCGAGACCGAGCAGGACCTGCTCGCCAGCC
CGCTGAAACTGCCCGCGCCCATCGTCGGCCACGTGGGCGACGGCAATTTCCACGTCGCGCTGCTGGTCGATCCGGACAAG
CCCGAGGAGCTGGAAGAAGCCGAGCGCATCAACCGGCGCATCGTGGCACGCGCCATCGCCATGGACGGCACCTGCACCGG
CGAGCACGGCGTGGGCCTGCACAAGATGGATTTCCTCGTCGCCGAGCATGGCGACGATGCGATCGACCTGATGCGCAGCG
TCAAGCAGGCGCTGGACCCGAAGCACATCCTGAACCCCGGCAAGATCTTCCGGCTGTAG

Upstream 100 bases:

>100_bases
GGTGTGGCGTGGGCATTATCGCAAGCCGCGCGCGACCCCGGCGTTAGAATGGGCTCCAAAAGGGGCGCCGCCCCAGCGCC
GGAGCCCATCGCGAGACGCC

Downstream 100 bases:

>100_bases
GCGCCAGCGCATGGCTTCCGTCTTCAAGCGCGTCCCGCCGCTGCATCTGCTGATCGCCTTCGAAGCGGGCGCGCGCCACG
CCAGCTTTGCGCGCGCGGCC

Product: D-lactate dehydrogenase (cytochrome) oxidoreductase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNHPLPHPGLARKPIPPAMLDALRARFGDRVSTSDAVRAHHGRDESAYDPMLPDAVVFAQTTEDVVAVARLCHEHAIPLI
PFGAGSSLEGHLLAVAGGVTLDLSQMNRVLSVHPEDLTVTVEPGVTRKQLNADIRDTGLFFPIDPGADASIGGMCATRAS
GTNAVRYGTMRENVLNLTVVTADGRVIKTANRARKSSAGYDLTRLFIGSEGTLGIITEITLRLYPQPEAVSAAVCAFPGM
GDAVCAVIDTIQMGVPVARVEFVDALAIRAINRYDKLSLPELPTLFFEFHGSAHGVQEQAETVQAIAAEHRGQGFEWATR
PEDRSRLWNARHNAYFAFLQLKPGCRAVTTDVCVPISRLADCVVETEQDLLASPLKLPAPIVGHVGDGNFHVALLVDPDK
PEELEEAERINRRIVARAIAMDGTCTGEHGVGLHKMDFLVAEHGDDAIDLMRSVKQALDPKHILNPGKIFRL

Sequences:

>Translated_472_residues
MNHPLPHPGLARKPIPPAMLDALRARFGDRVSTSDAVRAHHGRDESAYDPMLPDAVVFAQTTEDVVAVARLCHEHAIPLI
PFGAGSSLEGHLLAVAGGVTLDLSQMNRVLSVHPEDLTVTVEPGVTRKQLNADIRDTGLFFPIDPGADASIGGMCATRAS
GTNAVRYGTMRENVLNLTVVTADGRVIKTANRARKSSAGYDLTRLFIGSEGTLGIITEITLRLYPQPEAVSAAVCAFPGM
GDAVCAVIDTIQMGVPVARVEFVDALAIRAINRYDKLSLPELPTLFFEFHGSAHGVQEQAETVQAIAAEHRGQGFEWATR
PEDRSRLWNARHNAYFAFLQLKPGCRAVTTDVCVPISRLADCVVETEQDLLASPLKLPAPIVGHVGDGNFHVALLVDPDK
PEELEEAERINRRIVARAIAMDGTCTGEHGVGLHKMDFLVAEHGDDAIDLMRSVKQALDPKHILNPGKIFRL
>Mature_472_residues
MNHPLPHPGLARKPIPPAMLDALRARFGDRVSTSDAVRAHHGRDESAYDPMLPDAVVFAQTTEDVVAVARLCHEHAIPLI
PFGAGSSLEGHLLAVAGGVTLDLSQMNRVLSVHPEDLTVTVEPGVTRKQLNADIRDTGLFFPIDPGADASIGGMCATRAS
GTNAVRYGTMRENVLNLTVVTADGRVIKTANRARKSSAGYDLTRLFIGSEGTLGIITEITLRLYPQPEAVSAAVCAFPGM
GDAVCAVIDTIQMGVPVARVEFVDALAIRAINRYDKLSLPELPTLFFEFHGSAHGVQEQAETVQAIAAEHRGQGFEWATR
PEDRSRLWNARHNAYFAFLQLKPGCRAVTTDVCVPISRLADCVVETEQDLLASPLKLPAPIVGHVGDGNFHVALLVDPDK
PEELEEAERINRRIVARAIAMDGTCTGEHGVGLHKMDFLVAEHGDDAIDLMRSVKQALDPKHILNPGKIFRL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=456, Percent_Identity=53.7280701754386, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI37595754, Length=479, Percent_Identity=51.1482254697286, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI119964728, Length=422, Percent_Identity=32.4644549763033, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4501993, Length=459, Percent_Identity=26.1437908496732, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789351, Length=420, Percent_Identity=31.4285714285714, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1787977, Length=524, Percent_Identity=28.0534351145038, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI48994907, Length=493, Percent_Identity=25.9634888438134, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994914, Length=189, Percent_Identity=29.1005291005291, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=444, Percent_Identity=47.2972972972973, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71992381, Length=444, Percent_Identity=46.1711711711712, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71992392, Length=382, Percent_Identity=48.6910994764398, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17534361, Length=425, Percent_Identity=24, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17556096, Length=457, Percent_Identity=23.4135667396061, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320027, Length=430, Percent_Identity=41.8604651162791, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6320023, Length=487, Percent_Identity=26.2833675564682, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320764, Length=447, Percent_Identity=27.0693512304251, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18921117, Length=420, Percent_Identity=27.8571428571429, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24639277, Length=420, Percent_Identity=27.8571428571429, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24639275, Length=420, Percent_Identity=27.8571428571429, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653753, Length=460, Percent_Identity=26.304347826087, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 51008; Mature: 51008

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPLPHPGLARKPIPPAMLDALRARFGDRVSTSDAVRAHHGRDESAYDPMLPDAVVFAQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEC
TTEDVVAVARLCHEHAIPLIPFGAGSSLEGHLLAVAGGVTLDLSQMNRVLSVHPEDLTVT
CHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCEEEHHHHHHHEEECCCCEEEE
VEPGVTRKQLNADIRDTGLFFPIDPGADASIGGMCATRASGTNAVRYGTMRENVLNLTVV
ECCCCCHHHHCCCHHHCCEEEECCCCCCCCCCCEEEECCCCCCEEEECCHHCCEEEEEEE
TADGRVIKTANRARKSSAGYDLTRLFIGSEGTLGIITEITLRLYPQPEAVSAAVCAFPGM
ECCCCEEECHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCC
GDAVCAVIDTIQMGVPVARVEFVDALAIRAINRYDKLSLPELPTLFFEFHGSAHGVQEQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHEEECCCCCCHHHHH
ETVQAIAAEHRGQGFEWATRPEDRSRLWNARHNAYFAFLQLKPGCRAVTTDVCVPISRLA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHH
DCVVETEQDLLASPLKLPAPIVGHVGDGNFHVALLVDPDKPEELEEAERINRRIVARAIA
HHHHHCCHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
MDGTCTGEHGVGLHKMDFLVAEHGDDAIDLMRSVKQALDPKHILNPGKIFRL
CCCCCCCCCCCCEEHHHEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCEECC
>Mature Secondary Structure
MNHPLPHPGLARKPIPPAMLDALRARFGDRVSTSDAVRAHHGRDESAYDPMLPDAVVFAQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEC
TTEDVVAVARLCHEHAIPLIPFGAGSSLEGHLLAVAGGVTLDLSQMNRVLSVHPEDLTVT
CHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCEEEHHHHHHHEEECCCCEEEE
VEPGVTRKQLNADIRDTGLFFPIDPGADASIGGMCATRASGTNAVRYGTMRENVLNLTVV
ECCCCCHHHHCCCHHHCCEEEECCCCCCCCCCCEEEECCCCCCEEEECCHHCCEEEEEEE
TADGRVIKTANRARKSSAGYDLTRLFIGSEGTLGIITEITLRLYPQPEAVSAAVCAFPGM
ECCCCEEECHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCC
GDAVCAVIDTIQMGVPVARVEFVDALAIRAINRYDKLSLPELPTLFFEFHGSAHGVQEQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHEEECCCCCCHHHHH
ETVQAIAAEHRGQGFEWATRPEDRSRLWNARHNAYFAFLQLKPGCRAVTTDVCVPISRLA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHH
DCVVETEQDLLASPLKLPAPIVGHVGDGNFHVALLVDPDKPEELEEAERINRRIVARAIA
HHHHHCCHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
MDGTCTGEHGVGLHKMDFLVAEHGDDAIDLMRSVKQALDPKHILNPGKIFRL
CCCCCCCCCCCCEEHHHEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]