Click here to switch to the map view.

The map label for this gene is lip2 [H]

Identifier: 17546491

GI number: 17546491

Start: 1899253

End: 1900287

Strand: Direct

Name: lip2 [H]

Synonym: RSc1772

Alternate gene names: 17546491

Gene position: 1899253-1900287 (Clockwise)

Preceding gene: 17546489

Following gene: 17546492

Centisome position: 51.1

GC content: 70.14

Gene sequence:

>1035_bases
TTGCGGACGTGGTTCAATGGATACTCCGATGATAGTCAAATAAGAACGATCGTTCAGTTACGTCCCATGCCGTCCCTCGA
CCCGCACGTCGCCCAGCTGCTCGATCTGGTGGCGCGTGCCAAGCGTCCGCCGCTGCACCACCTGGCGCCCGCCGACGCCA
AGATCGCCTACGAGAAAAGCAGCCCCATCGTCGACATCCCGCCCATCCCGCTGGACCACGTGCACGACCTGACCGTGCCC
GCGCGCGACGGCTACGCGATTCCCGTGCGCACCTACGCCGCGCGCGAGGCGAGCTGGGCCGATCCGCTGCCGCTGCTGGT
GTATTTCCATGGCGGCGGCTTCACCGTCGGTAGCATCCGGACGCACGATGCGCTGTGCCGCTCGCTGGCGGCCAAGTCGG
GGGCGATGGTGCTGTCGGTCGACTACCGGCTCGGCCCCGACTGGAAATTCCCGACCGCGGCCGACGACGCGTTCGACGTG
CTGCAATGGGTGTTCGACGAGGCCGCCACGATCGGCGCCGATCCGGCCCGCATCGCCTTCGGCGGCGACAGCGCGGGCGG
CACGCTGGCGGCGATCACCGCCATCGAGGCGCGCAACCGCGGCCTGGCGCCCGTGCTGCAGCTGCTGATCTACCCCGGCA
CCACCGCGCGCGAGACCACGCCATCGCATCACGCCTTCGCCGAAGGCTACCTGCTGACGCAGGCCATGATCGCCTGGTTC
TTCGCCCAGTACCTGCGCAGCGACGCCGACCGCGACGACTGGCGCTTCGCCCCGCTGGACGGCGGCGGGCAGGGCGCCGA
CGTGCGGGGCGTGTGCCCGGCGTGGATCTCCGTGGCGGGCTTCGACCCGATCCGCGACGCCGGCATCGGCTACGCGGACA
AGCTGCGCGCGGCCGGCGTGCCGGTGACGCTGAAGATGTACGAGGGCATGATCCACGATTTCTTCAAGCTCGGCCGCTTC
GTGCCCGCGGTCGAAGACGCCCACTACGAGGCCGCCGACGCGCTGCGCCGCGCCTTCGGCACGCAGGCCGGATAG

Upstream 100 bases:

>100_bases
CATTCGCTGCCGAGCTCGCCGAGCGTGCCGAAGCCGAGGTGGACGTGGGTGAGGTAGAAGATGAGGGCCATGGGGTGTCT
CCGGAGCCGTCCGTCTTGTC

Downstream 100 bases:

>100_bases
GAGGAGCCCGACCCATGGCGATCGAGGATTTCCGCCACGGCACGCCGCTGCGCGTGCGCTGGGCCGAGGTCGATGCCCAG
GGCATCGTCTTCAACGGCCA

Product: esterase/lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRTWFNGYSDDSQIRTIVQLRPMPSLDPHVAQLLDLVARAKRPPLHHLAPADAKIAYEKSSPIVDIPPIPLDHVHDLTVP
ARDGYAIPVRTYAAREASWADPLPLLVYFHGGGFTVGSIRTHDALCRSLAAKSGAMVLSVDYRLGPDWKFPTAADDAFDV
LQWVFDEAATIGADPARIAFGGDSAGGTLAAITAIEARNRGLAPVLQLLIYPGTTARETTPSHHAFAEGYLLTQAMIAWF
FAQYLRSDADRDDWRFAPLDGGGQGADVRGVCPAWISVAGFDPIRDAGIGYADKLRAAGVPVTLKMYEGMIHDFFKLGRF
VPAVEDAHYEAADALRRAFGTQAG

Sequences:

>Translated_344_residues
MRTWFNGYSDDSQIRTIVQLRPMPSLDPHVAQLLDLVARAKRPPLHHLAPADAKIAYEKSSPIVDIPPIPLDHVHDLTVP
ARDGYAIPVRTYAAREASWADPLPLLVYFHGGGFTVGSIRTHDALCRSLAAKSGAMVLSVDYRLGPDWKFPTAADDAFDV
LQWVFDEAATIGADPARIAFGGDSAGGTLAAITAIEARNRGLAPVLQLLIYPGTTARETTPSHHAFAEGYLLTQAMIAWF
FAQYLRSDADRDDWRFAPLDGGGQGADVRGVCPAWISVAGFDPIRDAGIGYADKLRAAGVPVTLKMYEGMIHDFFKLGRF
VPAVEDAHYEAADALRRAFGTQAG
>Mature_344_residues
MRTWFNGYSDDSQIRTIVQLRPMPSLDPHVAQLLDLVARAKRPPLHHLAPADAKIAYEKSSPIVDIPPIPLDHVHDLTVP
ARDGYAIPVRTYAAREASWADPLPLLVYFHGGGFTVGSIRTHDALCRSLAAKSGAMVLSVDYRLGPDWKFPTAADDAFDV
LQWVFDEAATIGADPARIAFGGDSAGGTLAAITAIEARNRGLAPVLQLLIYPGTTARETTPSHHAFAEGYLLTQAMIAWF
FAQYLRSDADRDDWRFAPLDGGGQGADVRGVCPAWISVAGFDPIRDAGIGYADKLRAAGVPVTLKMYEGMIHDFFKLGRF
VPAVEDAHYEAADALRRAFGTQAG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=207, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI68299767, Length=355, Percent_Identity=25.0704225352113, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI206597554, Length=304, Percent_Identity=26.9736842105263, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI68051721, Length=270, Percent_Identity=26.2962962962963, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21328446, Length=224, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI61966717, Length=195, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI226423947, Length=278, Percent_Identity=25.1798561151079, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI68508967, Length=124, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI68508957, Length=124, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI68508965, Length=124, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786682, Length=256, Percent_Identity=29.296875, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17567059, Length=266, Percent_Identity=28.1954887218045, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI72001146, Length=148, Percent_Identity=32.4324324324324, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996133, Length=170, Percent_Identity=28.8235294117647, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540028, Length=170, Percent_Identity=30, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656084, Length=133, Percent_Identity=30.0751879699248, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656076, Length=133, Percent_Identity=30.0751879699248, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130169, Length=133, Percent_Identity=30.0751879699248, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 37323; Mature: 37323

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTWFNGYSDDSQIRTIVQLRPMPSLDPHVAQLLDLVARAKRPPLHHLAPADAKIAYEKS
CCCCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEECC
SPIVDIPPIPLDHVHDLTVPARDGYAIPVRTYAAREASWADPLPLLVYFHGGGFTVGSIR
CCEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCEEECCCH
THDALCRSLAAKSGAMVLSVDYRLGPDWKFPTAADDAFDVLQWVFDEAATIGADPARIAF
HHHHHHHHHHHCCCCEEEEEECEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
GGDSAGGTLAAITAIEARNRGLAPVLQLLIYPGTTARETTPSHHAFAEGYLLTQAMIAWF
CCCCCCCEEEEEEEHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FAQYLRSDADRDDWRFAPLDGGGQGADVRGVCPAWISVAGFDPIRDAGIGYADKLRAAGV
HHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHCCCCHHHHHHHCCC
PVTLKMYEGMIHDFFKLGRFVPAVEDAHYEAADALRRAFGTQAG
CEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTWFNGYSDDSQIRTIVQLRPMPSLDPHVAQLLDLVARAKRPPLHHLAPADAKIAYEKS
CCCCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEECC
SPIVDIPPIPLDHVHDLTVPARDGYAIPVRTYAAREASWADPLPLLVYFHGGGFTVGSIR
CCEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCEEECCCH
THDALCRSLAAKSGAMVLSVDYRLGPDWKFPTAADDAFDVLQWVFDEAATIGADPARIAF
HHHHHHHHHHHCCCCEEEEEECEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
GGDSAGGTLAAITAIEARNRGLAPVLQLLIYPGTTARETTPSHHAFAEGYLLTQAMIAWF
CCCCCCCEEEEEEEHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FAQYLRSDADRDDWRFAPLDGGGQGADVRGVCPAWISVAGFDPIRDAGIGYADKLRAAGV
HHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHCCCCHHHHHHHCCC
PVTLKMYEGMIHDFFKLGRFVPAVEDAHYEAADALRRAFGTQAG
CEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]