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The map label for this gene is livH1 [H]

Identifier: 17546470

GI number: 17546470

Start: 1874065

End: 1875012

Strand: Direct

Name: livH1 [H]

Synonym: RSc1751

Alternate gene names: 17546470

Gene position: 1874065-1875012 (Clockwise)

Preceding gene: 17546469

Following gene: 17546471

Centisome position: 50.43

GC content: 67.09

Gene sequence:

>948_bases
GTGGAATTCCTAGTCATCAACCTGTTGAACGGCATCAGCTACGGGCTGCTGCTGTTCATGCTGTCGTCGGGCCTGACGCT
GATCTTCAGCATGATGGGCGTCCTCAACTTCGCGCATGCCAGCTTCTACATGCTGGGCGCGTACTTCGCCTACGTCGTCA
GCGGATACCTGGGCTTCTGGGCCGCGCTGATCGTGGCGCCGCTGCTGGTGGGCGCGCTGGGGGCGCTGGTCGAGCGCTTC
GGCCTGCGCACGGTGCACCGCTACGGCCATGTCGCCGAGCTGCTGTTCACCTTCGGCCTGGCCTACCTGATCGAAGAGGG
CGTGAAGCTGGTGTGGGGCCTGCCGGCCGTGCCGTACCGCGTGCCCGAGGCGCTGGACGGGCCGCTGTTCACGCTGTTCA
CCTCGTCCTTCCCGAAGTACCGCGCCTTCATGATGCTGGTGTCGCTGCTGATGCTGGTGGGCATCTTCCTGCTGCTCACG
CGCACGCGCATCGGGCTGGTCATCCAGGCGGCGCTGACGCATCCGGACATGGTCGAGGCGCTCGGTCACAACGTGCCGCG
CGTCTTCATGCTGGTGTTCGGCGGGGGCTGCGCGCTGGCCGGGCTGGCCGGAGTGATCGGCGGCAACGCGTTCGTGACCG
AGCCGTCGATGGCGGCGGCGGTCGGGTCGATCGTCTTCGTGGTGGCGGTGGTGGGCGGCATGGGCTCGCTGGTGGGCGCC
TTCATCGCCTCGCTGCTGATCGGTTGCATCCAGACCTTTGCCGTCACGCTCGATGTGTCGGTGACGAGCCTGCTGGGCAA
GCTCGGTGTCGCGCTCAACCCGGACGTGCCGCTGATCTCCGTGTGGAACCTGACCATCGCGCAGGTGGCGCCGGTGCTGC
CGTACCTGCTGCTGGTGCTGATGCTGATCTTCCGCCCGCGCGGGCTGATGGGCACGCGGGAGGGATAA

Upstream 100 bases:

>100_bases
AACGGCCGCCCGATGCTATCGTGCGGCGATGTTTGAAACGGGCGGGGGCATGGGCCGGCACCGTTGGCCTATGCCCATGC
CGCGCCGAGAGGGCTGCAGC

Downstream 100 bases:

>100_bases
GCGCAAATGGACCGCGTCATGTCGCAACAACAGGCGTTGCCCGCCAACGATCGCGCCCGCACGATGCGGTTCAAGCCGCT
CAACCTCGCGCGCTGGCTGA

Product: amino acid transmembrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MEFLVINLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYVVSGYLGFWAALIVAPLLVGALGALVERF
GLRTVHRYGHVAELLFTFGLAYLIEEGVKLVWGLPAVPYRVPEALDGPLFTLFTSSFPKYRAFMMLVSLLMLVGIFLLLT
RTRIGLVIQAALTHPDMVEALGHNVPRVFMLVFGGGCALAGLAGVIGGNAFVTEPSMAAAVGSIVFVVAVVGGMGSLVGA
FIASLLIGCIQTFAVTLDVSVTSLLGKLGVALNPDVPLISVWNLTIAQVAPVLPYLLLVLMLIFRPRGLMGTREG

Sequences:

>Translated_315_residues
MEFLVINLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYVVSGYLGFWAALIVAPLLVGALGALVERF
GLRTVHRYGHVAELLFTFGLAYLIEEGVKLVWGLPAVPYRVPEALDGPLFTLFTSSFPKYRAFMMLVSLLMLVGIFLLLT
RTRIGLVIQAALTHPDMVEALGHNVPRVFMLVFGGGCALAGLAGVIGGNAFVTEPSMAAAVGSIVFVVAVVGGMGSLVGA
FIASLLIGCIQTFAVTLDVSVTSLLGKLGVALNPDVPLISVWNLTIAQVAPVLPYLLLVLMLIFRPRGLMGTREG
>Mature_315_residues
MEFLVINLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYVVSGYLGFWAALIVAPLLVGALGALVERF
GLRTVHRYGHVAELLFTFGLAYLIEEGVKLVWGLPAVPYRVPEALDGPLFTLFTSSFPKYRAFMMLVSLLMLVGIFLLLT
RTRIGLVIQAALTHPDMVEALGHNVPRVFMLVFGGGCALAGLAGVIGGNAFVTEPSMAAAVGSIVFVVAVVGGMGSLVGA
FIASLLIGCIQTFAVTLDVSVTSLLGKLGVALNPDVPLISVWNLTIAQVAPVLPYLLLVLMLIFRPRGLMGTREG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=267, Percent_Identity=26.2172284644195, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 33537; Mature: 33537

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLVINLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYVVSGYLGFW
CCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALIVAPLLVGALGALVERFGLRTVHRYGHVAELLFTFGLAYLIEEGVKLVWGLPAVPYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VPEALDGPLFTLFTSSFPKYRAFMMLVSLLMLVGIFLLLTRTRIGLVIQAALTHPDMVEA
CCHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LGHNVPRVFMLVFGGGCALAGLAGVIGGNAFVTEPSMAAAVGSIVFVVAVVGGMGSLVGA
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FIASLLIGCIQTFAVTLDVSVTSLLGKLGVALNPDVPLISVWNLTIAQVAPVLPYLLLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
MLIFRPRGLMGTREG
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MEFLVINLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYVVSGYLGFW
CCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALIVAPLLVGALGALVERFGLRTVHRYGHVAELLFTFGLAYLIEEGVKLVWGLPAVPYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VPEALDGPLFTLFTSSFPKYRAFMMLVSLLMLVGIFLLLTRTRIGLVIQAALTHPDMVEA
CCHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LGHNVPRVFMLVFGGGCALAGLAGVIGGNAFVTEPSMAAAVGSIVFVVAVVGGMGSLVGA
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FIASLLIGCIQTFAVTLDVSVTSLLGKLGVALNPDVPLISVWNLTIAQVAPVLPYLLLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
MLIFRPRGLMGTREG
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]