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The map label for this gene is pyrD

Identifier: 17546338

GI number: 17546338

Start: 1737914

End: 1738948

Strand: Direct

Name: pyrD

Synonym: RSc1619

Alternate gene names: 17546338

Gene position: 1737914-1738948 (Clockwise)

Preceding gene: 17546334

Following gene: 17546340

Centisome position: 46.76

GC content: 69.95

Gene sequence:

>1035_bases
GTGCTCAACGCCCTGTATCCGCTTGCTCGCCCGCTGCTGTTTTCGATGGACCCCGAAGACGCGCACCACTTCACGCTGAA
CCAGCTCAAGCGCGCGCATGCGCTGGGGCTGTCGGGCTGCATCGGCGCGCGCGTGGCGCCGCAGCCCCGCACGGTGATGG
GCATCGCGTTCCCGAACCCGGTCGGGCTGGCGGCGGGCCTGGACAAGGACGGCGCCTACATCGATGCGCTGGGCGCGCTC
GGCTTCGGCTTCATCGAAGTGGGCACCGTGACGCCGCGCGCGCAGCCGGGCAATCCGCGGCCGCGCATGTTCCGGCTGCC
GGCGGCGAGTGCGCTGATCAATCGCATGGGCTTCAACAACGGCGGCGTCGATGCGTTCATCCGCAATGTGCAGGCGTCGA
AGTGGCGCGAGGCGGGCGGCGTGCTGGGCCTGAACATCGGCAAGAACGCCGACACGCCGATCGAGCGCGCCGTCGACGAC
TACCTGCACTGTCTGGAGCGTGTCTACCCGTACGCCAGCTATGTGACGGTCAATATCTCGTCGCCGAACACCAAGAACCT
GCGCCAGCTGCAAGGCGCGAGCGAACTGGATAGCCTGCTCGGCACGCTGCGCGGGGCGCAGCAGCGCTTGGCCGACCAGC
ACAAGCGCTACGTGCCGGTGGTGCTGAAGATCGCGCCGGACCTGGACGATGACCAGATCGCCAACATTGGCGACGCATTG
CTGCGCCATCGGATGGACGGCGTGATCGCCACCAACACCACGATCCGCCGCGAAGCCGTGGCCGGCCTGCCGCATGCGGA
GGAGGCGGGCGGGCTGTCGGGGCAGCCCGTGCGGGAGGGCTCGACGCGCGTCATCCGCGCGCTGTGCGGCCTGCTGGGCG
ATGCGGTGCCCATTATCGGCGTGGGCGGCATCCTGGCCGGGGAGCATGCCCGGGAGAAGATCGACGCCGGCGCGCAGCTG
GTGCAGCTCTACACGGGGCTGATCTACCGCGGCCCGGGCCTGGTGGCCGAGTGCGCGCGCGCCCTGGCACGCTGA

Upstream 100 bases:

>100_bases
TGCGTCCGCGATGTTCGGGTGCGCTGTCAGATGCGTGCGCTCGTCCGGCGACGCCGTCCGTTTACAATGCGGCCTTTCGC
CTTCCTACGTTTTCACGATC

Downstream 100 bases:

>100_bases
GCCGATGCGCTATCGGCGCCGGAGCAGATAGATGACGACCGCGCTGACCGCCACCACGGCGGCGGCGAAGTCGTATGGGC
CGGCATAGTCGGCCCACAGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHALGLSGCIGARVAPQPRTVMGIAFPNPVGLAAGLDKDGAYIDALGAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPAASALINRMGFNNGGVDAFIRNVQASKWREAGGVLGLNIGKNADTPIERAVDD
YLHCLERVYPYASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVPVVLKIAPDLDDDQIANIGDAL
LRHRMDGVIATNTTIRREAVAGLPHAEEAGGLSGQPVREGSTRVIRALCGLLGDAVPIIGVGGILAGEHAREKIDAGAQL
VQLYTGLIYRGPGLVAECARALAR

Sequences:

>Translated_344_residues
MLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHALGLSGCIGARVAPQPRTVMGIAFPNPVGLAAGLDKDGAYIDALGAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPAASALINRMGFNNGGVDAFIRNVQASKWREAGGVLGLNIGKNADTPIERAVDD
YLHCLERVYPYASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVPVVLKIAPDLDDDQIANIGDAL
LRHRMDGVIATNTTIRREAVAGLPHAEEAGGLSGQPVREGSTRVIRALCGLLGDAVPIIGVGGILAGEHAREKIDAGAQL
VQLYTGLIYRGPGLVAECARALAR
>Mature_344_residues
MLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHALGLSGCIGARVAPQPRTVMGIAFPNPVGLAAGLDKDGAYIDALGAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPAASALINRMGFNNGGVDAFIRNVQASKWREAGGVLGLNIGKNADTPIERAVDD
YLHCLERVYPYASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVPVVLKIAPDLDDDQIANIGDAL
LRHRMDGVIATNTTIRREAVAGLPHAEEAGGLSGQPVREGSTRVIRALCGLLGDAVPIIGVGGILAGEHAREKIDAGAQL
VQLYTGLIYRGPGLVAECARALAR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=343, Percent_Identity=44.3148688046647, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=53.3132530120482, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17509475, Length=338, Percent_Identity=40.5325443786982, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=43.9189189189189, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=43.9189189189189, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_RALSO (Q8XYY7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519740.1
- ProteinModelPortal:   Q8XYY7
- SMR:   Q8XYY7
- GeneID:   1220454
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1619
- NMPDR:   fig|267608.1.peg.1619
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   RSOL267608:RSC1619-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36636; Mature: 36636

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHALGLSGCIGARVAPQPRTVMGIAFPNP
CCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCC
VGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNPRPRMFRLPAASALINRMGFNN
CCHHCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCC
GGVDAFIRNVQASKWREAGGVLGLNIGKNADTPIERAVDDYLHCLERVYPYASYVTVNIS
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
SPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVPVVLKIAPDLDDDQIANIGDAL
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
LRHRMDGVIATNTTIRREAVAGLPHAEEAGGLSGQPVREGSTRVIRALCGLLGDAVPIIG
HHHHHCCEEECCCHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHC
VGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECARALAR
CCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHALGLSGCIGARVAPQPRTVMGIAFPNP
CCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCC
VGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNPRPRMFRLPAASALINRMGFNN
CCHHCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCC
GGVDAFIRNVQASKWREAGGVLGLNIGKNADTPIERAVDDYLHCLERVYPYASYVTVNIS
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
SPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVPVVLKIAPDLDDDQIANIGDAL
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
LRHRMDGVIATNTTIRREAVAGLPHAEEAGGLSGQPVREGSTRVIRALCGLLGDAVPIIG
HHHHHCCEEECCCHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHC
VGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECARALAR
CCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852