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The map label for this gene is exuT2 [H]

Identifier: 17545799

GI number: 17545799

Start: 1136244

End: 1137542

Strand: Direct

Name: exuT2 [H]

Synonym: RSc1080

Alternate gene names: 17545799

Gene position: 1136244-1137542 (Clockwise)

Preceding gene: 17545798

Following gene: 17545800

Centisome position: 30.57

GC content: 68.13

Gene sequence:

>1299_bases
GTGAAGACCATCAAGGGCCTGCGCTGGTGGATCATCGCACTGGTGTGCCTGGGCACCATTACGAACTACCTGGCGCGCAA
TTCGCTCGGCGTGCTGGCGCCGCAGCTCAAGACCGAGCTGGGCATGAGCACACAGCAGTATTCCTACGTGGTCGGTGCGT
TCCAGATCGGCTACACGATCATGCAGCCGGTGTGCGGGTTCATCGTCGACCTGATCGGCCTGCGCATCGGCTTTGCGCTG
TTCGCGGTGCTGTGGTCGATTGCCGGCTGCCTGCATGCGGGCGCGTCGGGCTGGCTGTCGCTGGCGAGCTTCCGGGGGCT
GATGGGGCTGACCGAGGCCGCGGCCATCCCGTCGGGCATGAAGGCGGTGGCGGAGTGGTTTCCGGACAAGGAGAAATCCG
TCGCGGTGGGCTACTTCAATGCGGGCACGTCGCTGGGGGCCCTGCTGGCGCCGCCGCTGGTGGTGTTCCTGTCGCTGCGC
TACGGCTGGCAGTCGGCGTTCGTGGTGACGGGGGCGCTGGGTTTTGTGTGGGCCGCGCTGTGGTACGGCTTCTACCGCTC
GCCGCGCGAGCATGCCAAGCTGTCGGCCACCGAGCACGACCGGATCATCGGCGGGCAGATCCGCTCGGCGGGCGCCGCGC
GCGGCAAGCGGCCGGTGCGCGAGGTGGTGACGTCGCGGCGCTTCTGGGCGATCGCGCTGCCGCGCTTCTTTGCCGAGCCG
GCGTGGCAGACGTTCAGCTTCTGGATTCCGCTGTACCTGTCGAGCGCGCGGCACATGGACCTGAAGGAGATTGCGCTGTT
CGCCTGGCTGCCGTTTCTGGCGGCGGACCTGGGCGGGCTGCTGGGCGGCTATCTGTCGCCGTTCTTCATGAAGTTTTTCC
GCGTGCCGCTGATCTGGTCGCGCGTGTGCGGCGTGGTGCTGGGCGCGTTCCTGATGATCGGGCCGGCGTGCATCGGGCTG
GTGGCGTCGCCGTATCAGGCCATCGCGCTGTTCTGCGTGGGCGGCTTCGCGCACCAGATGATCTCGACCCTGGTCAACAC
GCTCAGCGCCGACGTCTTCGATCCGGAAGAGGTGGGCACCGCCAGCGGCTTTGCCGGCATGGCTGCGTGGATCGGCGGCC
TCGGCTTCTCGCTGATGGTCGGCGCGCTGGCCGACACCGTCGGCTACGGCCCGCTGTTCGGCCTGCTGGGCGCGTTCGAT
CTGATCGGCGCGACGCTGCTGATCCTGTTGATCCGCGGGCAGTCGCAGGAGGAGCGCGCGGCGCGCCAGATGCAGCACCA
CCTCTCCGCTTCCCATTGA

Upstream 100 bases:

>100_bases
CGGCCGTGCCTGGTGCGCTGAGGCGCGGCTAGGCCATCCGGGGGGCGCTGCGCCGCTCCCCTCGGTTTCAACCCATAAAA
AAGACATCCGGAGACAACGC

Downstream 100 bases:

>100_bases
GTTGATACCGATGTCCATGCTGCATCCTCCCCGCTTCGCGCTCCAGGCGCGTGAAGGCAATCACCTCCGCCTGGTCAGCG
CCACGGGTGCCGCGATCGAA

Product: hexuronate transporter transmembrane protein

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKTIKGLRWWIIALVCLGTITNYLARNSLGVLAPQLKTELGMSTQQYSYVVGAFQIGYTIMQPVCGFIVDLIGLRIGFAL
FAVLWSIAGCLHAGASGWLSLASFRGLMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGYFNAGTSLGALLAPPLVVFLSLR
YGWQSAFVVTGALGFVWAALWYGFYRSPREHAKLSATEHDRIIGGQIRSAGAARGKRPVREVVTSRRFWAIALPRFFAEP
AWQTFSFWIPLYLSSARHMDLKEIALFAWLPFLAADLGGLLGGYLSPFFMKFFRVPLIWSRVCGVVLGAFLMIGPACIGL
VASPYQAIALFCVGGFAHQMISTLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLMVGALADTVGYGPLFGLLGAFD
LIGATLLILLIRGQSQEERAARQMQHHLSASH

Sequences:

>Translated_432_residues
MKTIKGLRWWIIALVCLGTITNYLARNSLGVLAPQLKTELGMSTQQYSYVVGAFQIGYTIMQPVCGFIVDLIGLRIGFAL
FAVLWSIAGCLHAGASGWLSLASFRGLMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGYFNAGTSLGALLAPPLVVFLSLR
YGWQSAFVVTGALGFVWAALWYGFYRSPREHAKLSATEHDRIIGGQIRSAGAARGKRPVREVVTSRRFWAIALPRFFAEP
AWQTFSFWIPLYLSSARHMDLKEIALFAWLPFLAADLGGLLGGYLSPFFMKFFRVPLIWSRVCGVVLGAFLMIGPACIGL
VASPYQAIALFCVGGFAHQMISTLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLMVGALADTVGYGPLFGLLGAFD
LIGATLLILLIRGQSQEERAARQMQHHLSASH
>Mature_432_residues
MKTIKGLRWWIIALVCLGTITNYLARNSLGVLAPQLKTELGMSTQQYSYVVGAFQIGYTIMQPVCGFIVDLIGLRIGFAL
FAVLWSIAGCLHAGASGWLSLASFRGLMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGYFNAGTSLGALLAPPLVVFLSLR
YGWQSAFVVTGALGFVWAALWYGFYRSPREHAKLSATEHDRIIGGQIRSAGAARGKRPVREVVTSRRFWAIALPRFFAEP
AWQTFSFWIPLYLSSARHMDLKEIALFAWLPFLAADLGGLLGGYLSPFFMKFFRVPLIWSRVCGVVLGAFLMIGPACIGL
VASPYQAIALFCVGGFAHQMISTLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLMVGALADTVGYGPLFGLLGAFD
LIGATLLILLIRGQSQEERAARQMQHHLSASH

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI148743791, Length=398, Percent_Identity=26.3819095477387, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI148728191, Length=350, Percent_Identity=28.2857142857143, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI6912666, Length=438, Percent_Identity=23.7442922374429, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI154800443, Length=341, Percent_Identity=23.7536656891496, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI154350196, Length=409, Percent_Identity=24.9388753056235, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI5031955, Length=198, Percent_Identity=24.7474747474747, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367193, Length=433, Percent_Identity=50.8083140877598, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI87082320, Length=418, Percent_Identity=26.555023923445, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI2367379, Length=337, Percent_Identity=29.3768545994065, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789515, Length=320, Percent_Identity=27.1875, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789152, Length=398, Percent_Identity=25.1256281407035, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082310, Length=427, Percent_Identity=21.7798594847775, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788573, Length=437, Percent_Identity=21.2814645308924, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17560030, Length=360, Percent_Identity=26.1111111111111, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25141318, Length=278, Percent_Identity=26.6187050359712, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI86561091, Length=277, Percent_Identity=26.7148014440433, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25141316, Length=277, Percent_Identity=26.7148014440433, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554148, Length=365, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552542, Length=265, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25141341, Length=212, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193205400, Length=202, Percent_Identity=24.2574257425743, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20129235, Length=353, Percent_Identity=28.0453257790368, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648416, Length=289, Percent_Identity=28.0276816608997, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356189, Length=289, Percent_Identity=28.0276816608997, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24658658, Length=404, Percent_Identity=25.7425742574257, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641682, Length=386, Percent_Identity=24.8704663212435, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573708, Length=445, Percent_Identity=23.3707865168539, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573707, Length=445, Percent_Identity=23.3707865168539, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550460, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24655255, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639764, Length=295, Percent_Identity=21.0169491525424, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24580790, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922400, Length=247, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550364, Length=293, Percent_Identity=25.2559726962457, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24654215, Length=247, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20130135, Length=256, Percent_Identity=25.390625, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24658674, Length=281, Percent_Identity=24.5551601423488, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24655271, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573299, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46666; Mature: 46666

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]