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The map label for this gene is lrp [H]

Identifier: 17545646

GI number: 17545646

Start: 979581

End: 980078

Strand: Direct

Name: lrp [H]

Synonym: RSc0927

Alternate gene names: 17545646

Gene position: 979581-980078 (Clockwise)

Preceding gene: 17545644

Following gene: 17545647

Centisome position: 26.36

GC content: 64.46

Gene sequence:

>498_bases
ATGCGAACCCAGCGAAAACCCGTGCGCGCCCTCGACAAGCTCGACCGGCGCATCCTCGACCTGCTGCAGAAGGACGGCCG
GCTGTCCATGAAGGAGCTGTCCGACGCGGTCGGTCTGACCATCACGCCCTGCATCGAGCGGGTCAAGCGGCTGGAGCGGG
AGCGCTTCATCCTCGGCTACTACGCGCGGCTGAATCCGGCCATGCTCGGCGCATCGCTGCTCGTGTTCGTGGAGATCAGC
CTGGGTAGCAAGTCCGGCAACATGTTCGAGCAGTTCCGGCGCGAGGTCCTGCGCATTTCCGAGGTGCTGGAGTGCCACCT
CGTCTCCGGCGATTTCGACTACCTCATCAAGGCGCGCATCCGCGAGATGAGCGAGTACCGGCGCCTGCTCGGCGACATCC
TGCTGCAGCTGCCGGGCGCGGTGCAGTCCAAGAGCTACATCGTGATGGAAGAGATCAAGGAGACGCTTGCCATCGACGCG
ATCGGCGAAGACGCGTAG

Upstream 100 bases:

>100_bases
CGGAGATGCTATCGCGATAGATGGCGCTATCGTATTCCCACCTTTGTGCAAATTGTTTCTGTATATTCCTGAAAAACAGG
AATAAATTCGATTTTCGGCG

Downstream 100 bases:

>100_bases
CGGTAGTGCCCGCTGCCGCAAGGCGGTGGATGTGGCGGCGCGTCGCCGCGGCATGCATGGGGTGGTGGCCACGTCAAACC
GGCCGCCCGTCGAACTGACT

Product: leucine-responsive regulatory DNA-binding transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MRTQRKPVRALDKLDRRILDLLQKDGRLSMKELSDAVGLTITPCIERVKRLERERFILGYYARLNPAMLGASLLVFVEIS
LGSKSGNMFEQFRREVLRISEVLECHLVSGDFDYLIKARIREMSEYRRLLGDILLQLPGAVQSKSYIVMEEIKETLAIDA
IGEDA

Sequences:

>Translated_165_residues
MRTQRKPVRALDKLDRRILDLLQKDGRLSMKELSDAVGLTITPCIERVKRLERERFILGYYARLNPAMLGASLLVFVEIS
LGSKSGNMFEQFRREVLRISEVLECHLVSGDFDYLIKARIREMSEYRRLLGDILLQLPGAVQSKSYIVMEEIKETLAIDA
IGEDA
>Mature_165_residues
MRTQRKPVRALDKLDRRILDLLQKDGRLSMKELSDAVGLTITPCIERVKRLERERFILGYYARLNPAMLGASLLVFVEIS
LGSKSGNMFEQFRREVLRISEVLECHLVSGDFDYLIKARIREMSEYRRLLGDILLQLPGAVQSKSYIVMEEIKETLAIDA
IGEDA

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=56.8627450980392, Blast_Score=186, Evalue=9e-49,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=36.4864864864865, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18946; Mature: 18946

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQRKPVRALDKLDRRILDLLQKDGRLSMKELSDAVGLTITPCIERVKRLERERFILGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YARLNPAMLGASLLVFVEISLGSKSGNMFEQFRREVLRISEVLECHLVSGDFDYLIKARI
HHHHCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
REMSEYRRLLGDILLQLPGAVQSKSYIVMEEIKETLAIDAIGEDA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTQRKPVRALDKLDRRILDLLQKDGRLSMKELSDAVGLTITPCIERVKRLERERFILGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YARLNPAMLGASLLVFVEISLGSKSGNMFEQFRREVLRISEVLECHLVSGDFDYLIKARI
HHHHCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
REMSEYRRLLGDILLQLPGAVQSKSYIVMEEIKETLAIDAIGEDA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]