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The map label for this gene is cysM [H]

Identifier: 17545636

GI number: 17545636

Start: 968491

End: 969393

Strand: Direct

Name: cysM [H]

Synonym: RSc0917

Alternate gene names: 17545636

Gene position: 968491-969393 (Clockwise)

Preceding gene: 17545635

Following gene: 17545638

Centisome position: 26.06

GC content: 65.67

Gene sequence:

>903_bases
ATGGCTTATCCCACCATCGAAGACACCATCGGCAATACGCCGCTGGTCAGGCTCCAGCGCATTCCCGGCGAGGACAACGC
GCGACGCGGCAACGTGATCCTCGGCAAGCTCGAGGGCAACAATCCGGCCGGCTCGGTCAAGGATCGTCCGGCGCTTTCGA
TGATCAAGCATGCCGAGACGCGCGGCCGCATCAAGCCGGGCGACACGCTGATCGAAGCCACCTCGGGCAATACCGGTATC
GCGCTGGCGATGGCTGCTGCCATCCGCGGTTACAAGATGGTACTGATCATGCCGGAGGACTTGTCGGTCGAGCGCCGCCA
GAGCATGGCGGCGTACGGCGCGGAGATCGTCCTGACGCCGGTCAAGGGCGGCATGGAGTACGCCCGCGATCTGGCCGACG
CGATGGAGCGGGACGGCAAGGGCGTCATCCTCGACCAGTTCGCCAATCCTGACAATCCGCTGGCGCACTATGAAGGCACC
GGCCCGGAAATCTGGCGCGACACCGAAGGGCGCATTACCCATTTCGTCTCGGCGATGGGCACGACCGGCACCATCACCGG
CGTCTCGCGGTTCCTGAAGGAGAAGAATCCCGCCATCCAGATCGTCGGCGCGCAGCCGGCGGAAGGCTCGCGCATTCCCG
GCATCCGCAAGTGGCCGGAGGCGTATATGCCGAAGATCTACGATCCCAAGCACATCGATCGTACCGAGTCGGTCTCGCAG
TCCGATGCCGAGCACATGGCGCGTCGCATGGCGCGCGAGGAAGGGATCTTCTGCGGCATCTCGGCGGCGGGCGCGCTGTG
CGTGGCGCTGCGGGTGGCGGAGGCGGTCGAGAACGCGACCATCGTCTTTGTCGTTTGCGACCGGGGCGACCGCTACCTGT
CCACCGGCGTGTTTCCGGCCTGA

Upstream 100 bases:

>100_bases
GTCCGCCGATGCCCCGCCCGCGCGGGGCGGCGCGATGAGCCTGTCGCCAGCAGGGTTGCCGCGCTGCATTACAATGCCCC
GATTCCATCCGATACGCACC

Downstream 100 bases:

>100_bases
GCGGCACCACGCATCGGCATGAAAAAAGCGCAGCCAGGGCTGCGCTTTTTGTTTGCGGTGCGCCGGTGCGCGACCCGGCT
TCAGCCCCGCATGGCCTGGC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYPTIEDTIGNTPLVRLQRIPGEDNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAETRGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIVLTPVKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYEGT
GPEIWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIVGAQPAEGSRIPGIRKWPEAYMPKIYDPKHIDRTESVSQ
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEAVENATIVFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYPTIEDTIGNTPLVRLQRIPGEDNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAETRGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIVLTPVKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYEGT
GPEIWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIVGAQPAEGSRIPGIRKWPEAYMPKIYDPKHIDRTESVSQ
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEAVENATIVFVVCDRGDRYLSTGVFPA
>Mature_299_residues
AYPTIEDTIGNTPLVRLQRIPGEDNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAETRGRIKPGDTLIEATSGNTGIA
LAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIVLTPVKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYEGTG
PEIWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIVGAQPAEGSRIPGIRKWPEAYMPKIYDPKHIDRTESVSQS
DAEHMARRMAREEGIFCGISAAGALCVALRVAEAVENATIVFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=37.5404530744337, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=37.5404530744337, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=37.5404530744337, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=63.265306122449, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=43.6893203883495, Blast_Score=201, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=45.2459016393443, Blast_Score=233, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=42.7152317880795, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.4343434343434, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=41, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=40.5228758169935, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=36.5079365079365, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=38.3386581469649, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.2641509433962, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=37.0716510903427, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=37.9421221864952, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=37.9421221864952, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32450; Mature: 32318

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPTIEDTIGNTPLVRLQRIPGEDNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAET
CCCCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIVLTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYEGTGPEIWRDTEGRITHFVSAMG
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHC
TTGTITGVSRFLKEKNPAIQIVGAQPAEGSRIPGIRKWPEAYMPKIYDPKHIDRTESVSQ
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHCH
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEAVENATIVFVVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYPTIEDTIGNTPLVRLQRIPGEDNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAET
CCCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIVLTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYEGTGPEIWRDTEGRITHFVSAMG
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHC
TTGTITGVSRFLKEKNPAIQIVGAQPAEGSRIPGIRKWPEAYMPKIYDPKHIDRTESVSQ
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHCH
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEAVENATIVFVVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]