Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 17230234

GI number: 17230234

Start: 3339505

End: 3340647

Strand: Direct

Name: purK [H]

Synonym: alr2742

Alternate gene names: 17230234

Gene position: 3339505-3340647 (Clockwise)

Preceding gene: 17230233

Following gene: 17230235

Centisome position: 52.07

GC content: 43.22

Gene sequence:

>1143_bases
ATGAAGCGTGTAGGTGTAATTGGTGGTGGACAGCTGGCCTGGATGATGGGAGGCGCAGCGAATAAATTAGGGCTTGATTT
GATAGTGCAGACTCCTAGCAGTAATGATCCTGCCGTATCTATTGCCCAGGATATTGTTTTGGCAAATATTGATGATGCTC
ATGCCACAGAGATTTTAGCGAAAAAGAGTGACGTTATCACATTTGAAAACGAATTTGTCAATCTAGAGGCTTTATCGCTG
TTAGCAAATCAAGGTGTTTGTTTCCGTCCCAAGTTAGACGCTTTATCACCTCTATTAGATAAATATCATCAACGTTGCTA
TTTAAAAAATTTAGGTTTACCTGTTCCGCAATTTTTTGCCCTGGAAAACCAAGAGAATCTGATATCCAAAATAGATGATT
TGGGTTTTCCTTTAGTGTTGAAATCTCGCCGCCACGGTTATGACGGACAAGGTACTTTTATCATCCATGATTTAGCAACC
TTACAAGAGAAAATAGACTTAAATCACAATACAAACACCACATATTTAATAGAAGAATTTATTCCCTTTGAACGGGAGCT
AGCAGTAATCGCAGCTCGTTCTGTAGATGGAGAAGTTGTCATCTATCCTGTGGTAGAAACACAGCAAGAACAGCAAGTCT
GTAGGCGAGTTATAGCACCCGCCCATATTACACCCGATCAAGCCGCAGCAGCAGAAGCGATCGCCTCTACACTATTAAAT
AGTCTAGAAGTGGTTGGTGTGTTTGGAATTGAGTTATTTCTCACCGCCGATGGTCAAGTATTAGTCAATGAAATCGCTCC
CCGTACCCACAACTCTGGGCATTTTTCTCTAGATGCGTGCGAAACATCGCAATTTGAACAACACCTGAGAGCCATTTGTG
GACTACCGTTAGGAAACCCAGCATTGCAATGTGCTGGTACTGTTATGGTCAACCTACTAGGCTATGAAAACTCCCAAAGT
GATTACCAAAACCAGCGCCAACAACTAGCCGCCATCCCCCAAGCTCACGTTCATTGGTACGGCAAAACAGAATCTCGCCC
AGGGCGTAAACTCGGACACGTCACAGTTTTGTTAAATAATCATGACCAAACCACCGCCCAGGCGATTGCTCAAACCGTAG
AATCCATCTGGTATCCCACTTAG

Upstream 100 bases:

>100_bases
ATGCAATTTTGGATAAAGCACAAATTAAAGAACTTTGTACCAAAGCTAGCGGAGTAAATACAAAAACTGGTGTAGAAACT
CGTGATTCTTTGGGATGTCG

Downstream 100 bases:

>100_bases
GAAAGCAGAGAGAGAAATTTTTGCATTTTGAATTGGTAGAACCTGTTTTTGAAAGCTATAATGAGTGAGTTGCACTGCGA
CGTTGGTGACTGCCATCAAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKRVGVIGGGQLAWMMGGAANKLGLDLIVQTPSSNDPAVSIAQDIVLANIDDAHATEILAKKSDVITFENEFVNLEALSL
LANQGVCFRPKLDALSPLLDKYHQRCYLKNLGLPVPQFFALENQENLISKIDDLGFPLVLKSRRHGYDGQGTFIIHDLAT
LQEKIDLNHNTNTTYLIEEFIPFERELAVIAARSVDGEVVIYPVVETQQEQQVCRRVIAPAHITPDQAAAAEAIASTLLN
SLEVVGVFGIELFLTADGQVLVNEIAPRTHNSGHFSLDACETSQFEQHLRAICGLPLGNPALQCAGTVMVNLLGYENSQS
DYQNQRQQLAAIPQAHVHWYGKTESRPGRKLGHVTVLLNNHDQTTAQAIAQTVESIWYPT

Sequences:

>Translated_380_residues
MKRVGVIGGGQLAWMMGGAANKLGLDLIVQTPSSNDPAVSIAQDIVLANIDDAHATEILAKKSDVITFENEFVNLEALSL
LANQGVCFRPKLDALSPLLDKYHQRCYLKNLGLPVPQFFALENQENLISKIDDLGFPLVLKSRRHGYDGQGTFIIHDLAT
LQEKIDLNHNTNTTYLIEEFIPFERELAVIAARSVDGEVVIYPVVETQQEQQVCRRVIAPAHITPDQAAAAEAIASTLLN
SLEVVGVFGIELFLTADGQVLVNEIAPRTHNSGHFSLDACETSQFEQHLRAICGLPLGNPALQCAGTVMVNLLGYENSQS
DYQNQRQQLAAIPQAHVHWYGKTESRPGRKLGHVTVLLNNHDQTTAQAIAQTVESIWYPT
>Mature_380_residues
MKRVGVIGGGQLAWMMGGAANKLGLDLIVQTPSSNDPAVSIAQDIVLANIDDAHATEILAKKSDVITFENEFVNLEALSL
LANQGVCFRPKLDALSPLLDKYHQRCYLKNLGLPVPQFFALENQENLISKIDDLGFPLVLKSRRHGYDGQGTFIIHDLAT
LQEKIDLNHNTNTTYLIEEFIPFERELAVIAARSVDGEVVIYPVVETQQEQQVCRRVIAPAHITPDQAAAAEAIASTLLN
SLEVVGVFGIELFLTADGQVLVNEIAPRTHNSGHFSLDACETSQFEQHLRAICGLPLGNPALQCAGTVMVNLLGYENSQS
DYQNQRQQLAAIPQAHVHWYGKTESRPGRKLGHVTVLLNNHDQTTAQAIAQTVESIWYPT

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=366, Percent_Identity=31.1475409836066, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788155, Length=362, Percent_Identity=24.8618784530387, Blast_Score=95, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=35.792349726776, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41703; Mature: 41703

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVGVIGGGQLAWMMGGAANKLGLDLIVQTPSSNDPAVSIAQDIVLANIDDAHATEILA
CCCEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHEEEECCCCHHHHHHHH
KKSDVITFENEFVNLEALSLLANQGVCFRPKLDALSPLLDKYHQRCYLKNLGLPVPQFFA
CCCCEEEECCCEECHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEE
LENQENLISKIDDLGFPLVLKSRRHGYDGQGTFIIHDLATLQEKIDLNHNTNTTYLIEEF
ECCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEHHH
IPFERELAVIAARSVDGEVVIYPVVETQQEQQVCRRVIAPAHITPDQAAAAEAIASTLLN
CCCCHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SLEVVGVFGIELFLTADGQVLVNEIAPRTHNSGHFSLDACETSQFEQHLRAICGLPLGNP
HHHEEEEEEEEEEEECCCCEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCH
ALQCAGTVMVNLLGYENSQSDYQNQRQQLAAIPQAHVHWYGKTESRPGRKLGHVTVLLNN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEECEEEEEEEC
HDQTTAQAIAQTVESIWYPT
CCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRVGVIGGGQLAWMMGGAANKLGLDLIVQTPSSNDPAVSIAQDIVLANIDDAHATEILA
CCCEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHEEEECCCCHHHHHHHH
KKSDVITFENEFVNLEALSLLANQGVCFRPKLDALSPLLDKYHQRCYLKNLGLPVPQFFA
CCCCEEEECCCEECHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEE
LENQENLISKIDDLGFPLVLKSRRHGYDGQGTFIIHDLATLQEKIDLNHNTNTTYLIEEF
ECCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEHHH
IPFERELAVIAARSVDGEVVIYPVVETQQEQQVCRRVIAPAHITPDQAAAAEAIASTLLN
CCCCHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SLEVVGVFGIELFLTADGQVLVNEIAPRTHNSGHFSLDACETSQFEQHLRAICGLPLGNP
HHHEEEEEEEEEEEECCCCEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCH
ALQCAGTVMVNLLGYENSQSDYQNQRQQLAAIPQAHVHWYGKTESRPGRKLGHVTVLLNN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEECEEEEEEEC
HDQTTAQAIAQTVESIWYPT
CCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]