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The map label for this gene is pqqL [C]

Identifier: 17230235

GI number: 17230235

Start: 3341315

End: 3342559

Strand: Direct

Name: pqqL [C]

Synonym: alr2743

Alternate gene names: 17230235

Gene position: 3341315-3342559 (Clockwise)

Preceding gene: 17230234

Following gene: 17230236

Centisome position: 52.1

GC content: 44.26

Gene sequence:

>1245_bases
GTGTTTCCAGCCTCAGTGTTTCGATTAGACAACGGTTTGACATTTATTCATCAAGAAATTCCCACCACGCCTGTAGTTGT
GGCTGATGTCTGGGTGAGGGCTGGAGCAATTCGTGAACCAGAACCTTGGTTTGGGATGGCACACTTTCTAGAACACATGA
TTTTTAAAGGCACAGCCACCTTACCCCCAGGAACGTTTGATCATCAAATTGAGAACAGAGGTGGAGTAAGTAATGCCGCT
ACCAGCTACGATTACGCTAATTACTCTTTGACTACAGCCGCGTCTTACTTGACAGATACTCTACCTTACTTGGCAGATTT
ACTACTTAATGCGGCAATTCCAGATAATGAATTTAGCCGAGAGCGGGATGTAGTACTAGAGGAAATTCGTGCCTGCTATG
ATGATCCTGACTGGGTAGGATTTCAATGTCTGTCGCAGAGCATCTACCAAGACCATCCTTATGGGCGTTCAGTTCTGGGT
ACTGAAGAAGAACTGATGCAGCAATCACCAGAAGCGATGCGCCGTTTTCATCGCGCTCACTACCAACCGGAAAATATGAC
AGTAGTGATTGCTGGAGGTATTGCCCAACAAGCAGCCTGGGAACTGGTAAATCGTTCATTTGAGAATTTTTCTAAGCCTG
TTGAATGTCCGCTAGTTAAACCAGTAAGCAAACCAGTAATCAAGGGTATTCATCGTCAAGAGTTGAGTTTACCACGCATA
GAGCAAGCCCGATTGTTGATGGCATGGGTTGTACCAGGAGTAGAACAACTCCGCACAGCCTACGGTTTAGATTTGTTGTC
AGTGGTATTAGCAGAAGGGCGGACTTCTCGCCTAGTCAGGGATTTGCGAGAAGAACTACAATTAGTCCAAGGGATATGCA
GTAATTTTTCTCTGCAATGTGAATCGAGCTTATTTACAGTTACTGCTTGGTTGGAACCGGAAAACCTAGAACAAGTTGAG
GATTTAATTCTGAGTCATTTAGATGATATCCAAACCAGTGGTGTTAGCGAACAAGAAATAGCCCGTACCCGCAGACTTTT
ATGCAACGAGTACGCCTTCTCTACAGAAACCCCCAACCAGCTAACAGGGCTTTATGGCTACTACAACACCATCGCTCAAG
CAGAATTAGCAGTCACATATCCACACCAAATTCAATCATTTGATACCCAAGAACTGCAACAATTAGCTAAACAGCATCTT
TCTCTCCAGAATTACGCTGTTACCATCCTTAAACCTTATTCATAA

Upstream 100 bases:

>100_bases
ATGCGAATTTGGCGATCGTTCAGAGTTAAGATCACAAACATCAAAGTTAAATTGTGGTTAAAGATACAAAACCTTGTCAA
AACAACAACTTGCCAATCCT

Downstream 100 bases:

>100_bases
TGTCAGTCGTCAGTGGCTAGTAGTCCGAGGCTGCAAAGAAGTCGACAACTGAACAACTGACAACTGATAATTGACAACTG
ACAAATGACCCAAACCGTGA

Product: processing protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MFPASVFRLDNGLTFIHQEIPTTPVVVADVWVRAGAIREPEPWFGMAHFLEHMIFKGTATLPPGTFDHQIENRGGVSNAA
TSYDYANYSLTTAASYLTDTLPYLADLLLNAAIPDNEFSRERDVVLEEIRACYDDPDWVGFQCLSQSIYQDHPYGRSVLG
TEEELMQQSPEAMRRFHRAHYQPENMTVVIAGGIAQQAAWELVNRSFENFSKPVECPLVKPVSKPVIKGIHRQELSLPRI
EQARLLMAWVVPGVEQLRTAYGLDLLSVVLAEGRTSRLVRDLREELQLVQGICSNFSLQCESSLFTVTAWLEPENLEQVE
DLILSHLDDIQTSGVSEQEIARTRRLLCNEYAFSTETPNQLTGLYGYYNTIAQAELAVTYPHQIQSFDTQELQQLAKQHL
SLQNYAVTILKPYS

Sequences:

>Translated_414_residues
MFPASVFRLDNGLTFIHQEIPTTPVVVADVWVRAGAIREPEPWFGMAHFLEHMIFKGTATLPPGTFDHQIENRGGVSNAA
TSYDYANYSLTTAASYLTDTLPYLADLLLNAAIPDNEFSRERDVVLEEIRACYDDPDWVGFQCLSQSIYQDHPYGRSVLG
TEEELMQQSPEAMRRFHRAHYQPENMTVVIAGGIAQQAAWELVNRSFENFSKPVECPLVKPVSKPVIKGIHRQELSLPRI
EQARLLMAWVVPGVEQLRTAYGLDLLSVVLAEGRTSRLVRDLREELQLVQGICSNFSLQCESSLFTVTAWLEPENLEQVE
DLILSHLDDIQTSGVSEQEIARTRRLLCNEYAFSTETPNQLTGLYGYYNTIAQAELAVTYPHQIQSFDTQELQQLAKQHL
SLQNYAVTILKPYS
>Mature_414_residues
MFPASVFRLDNGLTFIHQEIPTTPVVVADVWVRAGAIREPEPWFGMAHFLEHMIFKGTATLPPGTFDHQIENRGGVSNAA
TSYDYANYSLTTAASYLTDTLPYLADLLLNAAIPDNEFSRERDVVLEEIRACYDDPDWVGFQCLSQSIYQDHPYGRSVLG
TEEELMQQSPEAMRRFHRAHYQPENMTVVIAGGIAQQAAWELVNRSFENFSKPVECPLVKPVSKPVIKGIHRQELSLPRI
EQARLLMAWVVPGVEQLRTAYGLDLLSVVLAEGRTSRLVRDLREELQLVQGICSNFSLQCESSLFTVTAWLEPENLEQVE
DLILSHLDDIQTSGVSEQEIARTRRLLCNEYAFSTETPNQLTGLYGYYNTIAQAELAVTYPHQIQSFDTQELQQLAKQHL
SLQNYAVTILKPYS

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=197, Percent_Identity=27.9187817258883, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI94538354, Length=199, Percent_Identity=30.1507537688442, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI155969707, Length=339, Percent_Identity=24.188790560472, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI156071450, Length=358, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI156071452, Length=353, Percent_Identity=21.8130311614731, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787770, Length=218, Percent_Identity=29.8165137614679, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI2367164, Length=350, Percent_Identity=24.2857142857143, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=212, Percent_Identity=26.8867924528302, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17553678, Length=219, Percent_Identity=27.8538812785388, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994338, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146566, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146563, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566665, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72001443, Length=192, Percent_Identity=26.5625, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=221, Percent_Identity=28.9592760180996, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357875, Length=214, Percent_Identity=28.9719626168224, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646943, Length=214, Percent_Identity=28.9719626168224, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24641429, Length=304, Percent_Identity=27.6315789473684, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667786, Length=407, Percent_Identity=21.3759213759214, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46816; Mature: 46816

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPASVFRLDNGLTFIHQEIPTTPVVVADVWVRAGAIREPEPWFGMAHFLEHMIFKGTAT
CCCCHHEEECCCCEEEHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
LPPGTFDHQIENRGGVSNAATSYDYANYSLTTAASYLTDTLPYLADLLLNAAIPDNEFSR
CCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ERDVVLEEIRACYDDPDWVGFQCLSQSIYQDHPYGRSVLGTEEELMQQSPEAMRRFHRAH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHC
YQPENMTVVIAGGIAQQAAWELVNRSFENFSKPVECPLVKPVSKPVIKGIHRQELSLPRI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
EQARLLMAWVVPGVEQLRTAYGLDLLSVVLAEGRTSRLVRDLREELQLVQGICSNFSLQC
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
ESSLFTVTAWLEPENLEQVEDLILSHLDDIQTSGVSEQEIARTRRLLCNEYAFSTETPNQ
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHH
LTGLYGYYNTIAQAELAVTYPHQIQSFDTQELQQLAKQHLSLQNYAVTILKPYS
HHHHHHHHHHHHHHHEEEECCHHHHCCCHHHHHHHHHHHHCHHHEEEEEEECCC
>Mature Secondary Structure
MFPASVFRLDNGLTFIHQEIPTTPVVVADVWVRAGAIREPEPWFGMAHFLEHMIFKGTAT
CCCCHHEEECCCCEEEHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
LPPGTFDHQIENRGGVSNAATSYDYANYSLTTAASYLTDTLPYLADLLLNAAIPDNEFSR
CCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ERDVVLEEIRACYDDPDWVGFQCLSQSIYQDHPYGRSVLGTEEELMQQSPEAMRRFHRAH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHC
YQPENMTVVIAGGIAQQAAWELVNRSFENFSKPVECPLVKPVSKPVIKGIHRQELSLPRI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
EQARLLMAWVVPGVEQLRTAYGLDLLSVVLAEGRTSRLVRDLREELQLVQGICSNFSLQC
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
ESSLFTVTAWLEPENLEQVEDLILSHLDDIQTSGVSEQEIARTRRLLCNEYAFSTETPNQ
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHH
LTGLYGYYNTIAQAELAVTYPHQIQSFDTQELQQLAKQHLSLQNYAVTILKPYS
HHHHHHHHHHHHHHHEEEECCHHHHCCCHHHHHHHHHHHHCHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA