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The map label for this gene is pdhA [H]

Identifier: 17230200

GI number: 17230200

Start: 3303708

End: 3304742

Strand: Direct

Name: pdhA [H]

Synonym: alr2708

Alternate gene names: 17230200

Gene position: 3303708-3304742 (Clockwise)

Preceding gene: 17230190

Following gene: 17230201

Centisome position: 51.51

GC content: 47.83

Gene sequence:

>1035_bases
ATGGTTCAAGAACGCACAATACCTAAATTTAATACTGCCAACGCCAAAATCACCAAAGAAGAAGGGCTTCTTTTATACGA
AGACATGACTTTGGGGCGTTTTTTTGAAGATAAATGTGCCGAAATGTACTACAGAGGCAAAATGTTTGGTTTTGTCCACT
TGTACAACGGACAAGAAGCAGTTTCTACTGGCGTAATTCAAGCGATGCGACCAGGGGAAGATTTTGTTAGCAGTACCTAC
CGCGACCACGTTCATGCTTTGAGTGCTGGAGTCCCAGCTAGAGAAGTCATGGCGGAGTTATTTGGCAAAGCCACAGGTTG
CAGCAAAGGGCGCGGCGGTTCCATGCATATGTTTTCCGCCGAACATGGCTTATTAGGCGGCTATGCTTTCGTTGCGGAAG
GAATTCCTGTAGCAGCTGGTGCAGCTTTTCAAAGTAAATACCGCCGGGAAGTTTTGGGAGACCCCAACGCCGACCAGGTA
ACAGCTTGCTTCTTCGGTGATGGTGCAGCTAATAACGGGCAGTTCTTTGAAACTCTCAATATGGCTGCTCTTTGGAAACT
GCCAATTATTTTCGTGGTAGAAAATAATAAGTGGGCCATTGGTATGGCTCACGACCGAGCAACTTCTGACCCAGAGATTT
ACAAAAAAGCCAGCGTCTTTAACATGGTTGGCGTAGAAGTAGATGGTATGGATGTGCTGGCGGTGCGTGCAGTCGCGCAA
GAAGCCGTAGCCCGTGCGCGTGCTGGTGAAGGCCCGACCTTAATAGAAGCTCTAACCTACCGTTTCCGTGGTCACTCTTT
GGCAGACCCGGATGAAATGCGTAGCAAAGCTGAGAAAGAATTTTGGTTTTCCCGTGACCCAATTAAGAAGCTAGCAGCTT
ATCTAATAGAGCAGAACTTGGCAGATGAGGCAGAACTCAAAGCCATCGAGCGCAAGATTCAGGACGTGATTGATGATGCG
GTGAAGTTCGCAGAAAGTAGCCCTGAACCAGACCCCAGCGAATTGTATCGCTTTGTCTTCGCAGAAGACGAATAA

Upstream 100 bases:

>100_bases
TGTTCACTCTAGTAAACCCTGCTGGGGAAAATAAAATTGCTCAGAAAACAACCTATTTAAAATGGTAAATTTCGATTTTA
GACAGGAATACTAAAAAATA

Downstream 100 bases:

>100_bases
ATTGAGGACTGGGGATTAGGGATTGGGGATTAGGGATTATATATTTAGCTCTGAACCCCAATGCTTCTAGCCCCTAATCT
CTCGCCTCCAGCCCCTAGCC

Product: pyruvate dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVQERTIPKFNTANAKITKEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGVIQAMRPGEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSAEHGLLGGYAFVAEGIPVAAGAAFQSKYRREVLGDPNADQV
TACFFGDGAANNGQFFETLNMAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYKKASVFNMVGVEVDGMDVLAVRAVAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDEMRSKAEKEFWFSRDPIKKLAAYLIEQNLADEAELKAIERKIQDVIDDA
VKFAESSPEPDPSELYRFVFAEDE

Sequences:

>Translated_344_residues
MVQERTIPKFNTANAKITKEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGVIQAMRPGEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSAEHGLLGGYAFVAEGIPVAAGAAFQSKYRREVLGDPNADQV
TACFFGDGAANNGQFFETLNMAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYKKASVFNMVGVEVDGMDVLAVRAVAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDEMRSKAEKEFWFSRDPIKKLAAYLIEQNLADEAELKAIERKIQDVIDDA
VKFAESSPEPDPSELYRFVFAEDE
>Mature_344_residues
MVQERTIPKFNTANAKITKEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGVIQAMRPGEDFVSSTY
RDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSAEHGLLGGYAFVAEGIPVAAGAAFQSKYRREVLGDPNADQV
TACFFGDGAANNGQFFETLNMAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYKKASVFNMVGVEVDGMDVLAVRAVAQ
EAVARARAGEGPTLIEALTYRFRGHSLADPDEMRSKAEKEFWFSRDPIKKLAAYLIEQNLADEAELKAIERKIQDVIDDA
VKFAESSPEPDPSELYRFVFAEDE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=39.5136778115502, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=39.5136778115502, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=39.5136778115502, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=38.6904761904762, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=35.8662613981763, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI11386135, Length=333, Percent_Identity=31.5315315315315, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI258645172, Length=338, Percent_Identity=31.6568047337278, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=334, Percent_Identity=38.622754491018, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17536047, Length=334, Percent_Identity=38.622754491018, Blast_Score=226, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI86563355, Length=326, Percent_Identity=26.3803680981595, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI86563357, Length=326, Percent_Identity=26.3803680981595, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=37.0253164556962, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24639748, Length=339, Percent_Identity=40.117994100295, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24639744, Length=330, Percent_Identity=38.4848484848485, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28571106, Length=330, Percent_Identity=38.4848484848485, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24639740, Length=330, Percent_Identity=38.4848484848485, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=38.6581469648562, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21355903, Length=334, Percent_Identity=25.748502994012, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38046; Mature: 38046

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQERTIPKFNTANAKITKEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
VSTGVIQAMRPGEDFVSSTYRDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEC
EHGLLGGYAFVAEGIPVAAGAAFQSKYRREVLGDPNADQVTACFFGDGAANNGQFFETLN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHH
MAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYKKASVFNMVGVEVDGMDVLAVRAVAQ
HHHHCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHEECEEECCCHHHHHHHHHH
EAVARARAGEGPTLIEALTYRFRGHSLADPDEMRSKAEKEFWFSRDPIKKLAAYLIEQNL
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
ADEAELKAIERKIQDVIDDAVKFAESSPEPDPSELYRFVFAEDE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCC
>Mature Secondary Structure
MVQERTIPKFNTANAKITKEEGLLLYEDMTLGRFFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
VSTGVIQAMRPGEDFVSSTYRDHVHALSAGVPAREVMAELFGKATGCSKGRGGSMHMFSA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEC
EHGLLGGYAFVAEGIPVAAGAAFQSKYRREVLGDPNADQVTACFFGDGAANNGQFFETLN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHH
MAALWKLPIIFVVENNKWAIGMAHDRATSDPEIYKKASVFNMVGVEVDGMDVLAVRAVAQ
HHHHCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHEECEEECCCHHHHHHHHHH
EAVARARAGEGPTLIEALTYRFRGHSLADPDEMRSKAEKEFWFSRDPIKKLAAYLIEQNL
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
ADEAELKAIERKIQDVIDDAVKFAESSPEPDPSELYRFVFAEDE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]