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The map label for this gene is coxB [H]

Identifier: 17230006

GI number: 17230006

Start: 3021198

End: 3022181

Strand: Direct

Name: coxB [H]

Synonym: alr2514

Alternate gene names: 17230006

Gene position: 3021198-3022181 (Clockwise)

Preceding gene: 17230005

Following gene: 17230007

Centisome position: 47.1

GC content: 44.41

Gene sequence:

>984_bases
ATGCAGCAAATTCCTGTTTCACTCTGGACTCTAATTGCTGGAATAGTAGTTGGAGTAATCAGTCTTTGGATTGGTCAAAA
TCACAACCTACTACCTATTCAAGCATCAGAACAAGCGCCTTTGGTAGACGGATTTTTTAATATTATGTTTACCATTGCTG
TGGCGCTGTTTTTGGTAGTAGAAGGCACGATTCTGATTTTCTTATTTAAGTATCGTCGTCGTCGGGGTGATAATACCGAT
GGCGTACCAGTGGAAGGGAACGTTCCCTTAGAGATTTTCTGGACGGCAATTCCATCAATAATTGTGATTTGCTTAGGTAT
CTATAGTGTAGATGTCTTTAACCAAATGGGAGGATTAGAACCTGGGACTCATCCCCATGCTTCCGCTCATGTGGCGCACT
CTTCAGGTACGGCATTAGCAGCAACACTAAACGATACCTCGACATCTGCAATTAATCCAGGGATTGGTATTGGTGCAAGT
CCGACAACTGCCGGTAAAACCGCAGACTTAGTTGTCAATGTGACTGGGATGCAGTTTGCTTGGTTATTCGATTATCCTGA
TAACGGTGTTTCCGCCGGAGAACTACACGTTCCGGTAGGTGCTGATGTACAACTTAATCTTTCAGCACAGGATGTGATTC
ACTCATTCTGGGTTCCCCAATTCCGACTGAAGCAAGACGCAATTCCTGGGGTTCCTACCGAATTAAGATTCGTAGCTACC
AAACCAGGGACATATCCGGTAGTGTGCGCTGAACTTTGTGGTGGTTATCATGGTTCAATGCGGACACAGGTTATTGTCCA
CACACCAGAGGAGTTTGATAGCTGGCTTGCAGAAAATCAGGTTGCTCAACAACAAAATCTACATCAGGCTGTTGCAGTTA
ACCCAGCTAATTTATCAACATCCGAGTTTCTCGCACCCCACACCCAAGATTTGGGAATTAGTGCAGCCACTTTAGAGACA
TTGCATACAACGTCTGTAAATTAG

Upstream 100 bases:

>100_bases
CCCTTCGGGTTCGCCAGTTCCTTACGGAGGGAAACCCTCCTACAGGACTGGACTCACCAATTACCAATTCCCAATTTCGA
TAAGTAAATGAGTAGGTGGT

Downstream 100 bases:

>100_bases
TGGATTCTTCAAAAATTCTGGCACAATAGCTTATGACACGAGTTGAATTTCCACCACACATTCCGCCAGATGACAATCAG
CCGAAAAATTTGGCGGTTGG

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MQQIPVSLWTLIAGIVVGVISLWIGQNHNLLPIQASEQAPLVDGFFNIMFTIAVALFLVVEGTILIFLFKYRRRRGDNTD
GVPVEGNVPLEIFWTAIPSIIVICLGIYSVDVFNQMGGLEPGTHPHASAHVAHSSGTALAATLNDTSTSAINPGIGIGAS
PTTAGKTADLVVNVTGMQFAWLFDYPDNGVSAGELHVPVGADVQLNLSAQDVIHSFWVPQFRLKQDAIPGVPTELRFVAT
KPGTYPVVCAELCGGYHGSMRTQVIVHTPEEFDSWLAENQVAQQQNLHQAVAVNPANLSTSEFLAPHTQDLGISAATLET
LHTTSVN

Sequences:

>Translated_327_residues
MQQIPVSLWTLIAGIVVGVISLWIGQNHNLLPIQASEQAPLVDGFFNIMFTIAVALFLVVEGTILIFLFKYRRRRGDNTD
GVPVEGNVPLEIFWTAIPSIIVICLGIYSVDVFNQMGGLEPGTHPHASAHVAHSSGTALAATLNDTSTSAINPGIGIGAS
PTTAGKTADLVVNVTGMQFAWLFDYPDNGVSAGELHVPVGADVQLNLSAQDVIHSFWVPQFRLKQDAIPGVPTELRFVAT
KPGTYPVVCAELCGGYHGSMRTQVIVHTPEEFDSWLAENQVAQQQNLHQAVAVNPANLSTSEFLAPHTQDLGISAATLET
LHTTSVN
>Mature_327_residues
MQQIPVSLWTLIAGIVVGVISLWIGQNHNLLPIQASEQAPLVDGFFNIMFTIAVALFLVVEGTILIFLFKYRRRRGDNTD
GVPVEGNVPLEIFWTAIPSIIVICLGIYSVDVFNQMGGLEPGTHPHASAHVAHSSGTALAATLNDTSTSAINPGIGIGAS
PTTAGKTADLVVNVTGMQFAWLFDYPDNGVSAGELHVPVGADVQLNLSAQDVIHSFWVPQFRLKQDAIPGVPTELRFVAT
KPGTYPVVCAELCGGYHGSMRTQVIVHTPEEFDSWLAENQVAQQQNLHQAVAVNPANLSTSEFLAPHTQDLGISAATLET
LHTTSVN

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=113, Percent_Identity=32.7433628318584, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786635, Length=248, Percent_Identity=23.7903225806452, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 35006; Mature: 35006

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQIPVSLWTLIAGIVVGVISLWIGQNHNLLPIQASEQAPLVDGFFNIMFTIAVALFLVV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
EGTILIFLFKYRRRRGDNTDGVPVEGNVPLEIFWTAIPSIIVICLGIYSVDVFNQMGGLE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PGTHPHASAHVAHSSGTALAATLNDTSTSAINPGIGIGASPTTAGKTADLVVNVTGMQFA
CCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEE
WLFDYPDNGVSAGELHVPVGADVQLNLSAQDVIHSFWVPQFRLKQDAIPGVPTELRFVAT
EEEECCCCCCCCCEEEECCCCCEEEECCHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEE
KPGTYPVVCAELCGGYHGSMRTQVIVHTPEEFDSWLAENQVAQQQNLHQAVAVNPANLST
CCCCCHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
SEFLAPHTQDLGISAATLETLHTTSVN
HHHCCCCCHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MQQIPVSLWTLIAGIVVGVISLWIGQNHNLLPIQASEQAPLVDGFFNIMFTIAVALFLVV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
EGTILIFLFKYRRRRGDNTDGVPVEGNVPLEIFWTAIPSIIVICLGIYSVDVFNQMGGLE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PGTHPHASAHVAHSSGTALAATLNDTSTSAINPGIGIGASPTTAGKTADLVVNVTGMQFA
CCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEE
WLFDYPDNGVSAGELHVPVGADVQLNLSAQDVIHSFWVPQFRLKQDAIPGVPTELRFVAT
EEEECCCCCCCCCEEEECCCCCEEEECCHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEE
KPGTYPVVCAELCGGYHGSMRTQVIVHTPEEFDSWLAENQVAQQQNLHQAVAVNPANLST
CCCCCHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
SEFLAPHTQDLGISAATLETLHTTSVN
HHHCCCCCHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1659815; 8399373 [H]