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The map label for this gene is coxA [H]

Identifier: 17230007

GI number: 17230007

Start: 3022214

End: 3023893

Strand: Direct

Name: coxA [H]

Synonym: alr2515

Alternate gene names: 17230007

Gene position: 3022214-3023893 (Clockwise)

Preceding gene: 17230006

Following gene: 17230008

Centisome position: 47.12

GC content: 46.49

Gene sequence:

>1680_bases
ATGACACGAGTTGAATTTCCACCACACATTCCGCCAGATGACAATCAGCCGAAAAATTTGGCGGTTGGACATGGCTTAAC
TCTGCCAGCTTGGAAATGGCGAGATTACTTTACTTTTAATGTAGACCATAAGGTTATTGGTATCCAATACCTGGTGACAG
CGTTTTTGTTCTATCTAATCGGTGGGTTGATGGCGATCGCTATCCGTACCGAGTTAGCAACACCTGATGCAGACTTCATT
GATCCGAATCTGTACAACGCATTCATGACCAATCACGGAACAATCATGATTTTCCTCTGGATTGTTCCTAGTGCTATTGG
GGGTTTTGGTAATTATCTCATACCCTTGATGATTGGGGCGCGGGATATGGCGTTTCCCAAACTGAATGCGATCGCCTTTT
GGTTAAACCCACCAGCCGGCTTACTCTTGTTACTCAGCTTTATTTTTGGTGGTTCTCAGTCTGGTTGGACTGCTTACCCA
CCTTTGAGTTTAGTCACAGCGCCAACTGCTCAAACTTTGTGGATTTTGGCGATTGTATTAGTAGGGACTTCTTCCATTCT
GGGTTCTGTGAACTTCGTTGTCACCATCTTGATGATGAAGGTTCCGAGCATGAAATGGGATCAACTACCTTTGTTCTGCT
GGGCAATTTTGGCAACATCCGTACTAGCACTACTCTCTACACCAGTGTTAGCTGCGGGTTTAGTTCTGCTATTATTTGAC
CTCAACTTTGGTACTTCCTTCTTCAAACCAGATGCTGGCGGTAACGTCGTTATCTATCAACATTTGTTCTGGTTCTACTC
TCACCCAGCAGTATATTTGATGATTCTGCCCATCTTCGGCATTATGTCGGAGGTGATTCCCGTTCATGCGCGGAAACCAA
TTTTTGGTTATAAGGCGATCGCCTATTCTAGTGTCGCCATCTGTGTGGTCGGTTTGTTCGTCTGGGTTCACCATATGTTT
ACCAGTGGTACACCCGGTTGGATGCGGATGTTCTTTACCATCTCTACCTTGATTGTTGCTGTTCCGACGGGTGTGAAAAT
TTTCGGTTGGGTGGCGACCTTGTGGGGTGGAAAGATTCGCTTTACCAGCGCCATGCTGTTTGCTATTGGCTTGTTATCCA
TGTTTGTCATGGGCGGCTTAAGCGGCGTAACGATGGGTACAGCGCCTTTTGACGTTCACGTCCACGATACCTATTATGTA
GTGGCACACTTCCACTACGTTCTGTTTGGTGGTTCTGTGTTTGGGATTTACGCCGGGATTTATCACTGGTTCCCCAAAAT
GACAGGGCGGAAGTTGGGTGAAGGTTGGGGTCGGATTCACTTTGCCCTGACCTTGGTTGGAACTAACTTAACTTTCTTAC
CCATGCACAAATTGGGCTTGCAAGGTATGCCCCGACGGGTGGCGATGTATGATCCTCAATTTGTGGATTTGAATGTGCTT
TGTACTATCGGTGCATTCATCTTAGGCTTATCGGTGATTCCTTTTGCCATCAATGTTATCTGGAGTTGGAGCAAGGGCGA
ATTGGCTGGGGATAATCCTTGGGAAGCTTTGAGCCTGGAATGGACTACTAGTTCTCCTCCTTTGGTGGAGAATTGGGAAG
TTCTGCCTGTGGTGACTCATGGGCCTTATGACTATGGTCATAGTTTGGAAGCCGCACCGGAAGTAAGTGTATCAACCTAA

Upstream 100 bases:

>100_bases
CCCACACCCAAGATTTGGGAATTAGTGCAGCCACTTTAGAGACATTGCATACAACGTCTGTAAATTAGTGGATTCTTCAA
AAATTCTGGCACAATAGCTT

Downstream 100 bases:

>100_bases
CCCCCTAACCCCCTTCCCTACGAGGGAAGGGGGAATAAGAAAGGTTCTCCTCTCTGACCTTCGGCACGCTCCGCGAACGA
AGAAAATTTAGGAGAGGGGT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MTRVEFPPHIPPDDNQPKNLAVGHGLTLPAWKWRDYFTFNVDHKVIGIQYLVTAFLFYLIGGLMAIAIRTELATPDADFI
DPNLYNAFMTNHGTIMIFLWIVPSAIGGFGNYLIPLMIGARDMAFPKLNAIAFWLNPPAGLLLLLSFIFGGSQSGWTAYP
PLSLVTAPTAQTLWILAIVLVGTSSILGSVNFVVTILMMKVPSMKWDQLPLFCWAILATSVLALLSTPVLAAGLVLLLFD
LNFGTSFFKPDAGGNVVIYQHLFWFYSHPAVYLMILPIFGIMSEVIPVHARKPIFGYKAIAYSSVAICVVGLFVWVHHMF
TSGTPGWMRMFFTISTLIVAVPTGVKIFGWVATLWGGKIRFTSAMLFAIGLLSMFVMGGLSGVTMGTAPFDVHVHDTYYV
VAHFHYVLFGGSVFGIYAGIYHWFPKMTGRKLGEGWGRIHFALTLVGTNLTFLPMHKLGLQGMPRRVAMYDPQFVDLNVL
CTIGAFILGLSVIPFAINVIWSWSKGELAGDNPWEALSLEWTTSSPPLVENWEVLPVVTHGPYDYGHSLEAAPEVSVST

Sequences:

>Translated_559_residues
MTRVEFPPHIPPDDNQPKNLAVGHGLTLPAWKWRDYFTFNVDHKVIGIQYLVTAFLFYLIGGLMAIAIRTELATPDADFI
DPNLYNAFMTNHGTIMIFLWIVPSAIGGFGNYLIPLMIGARDMAFPKLNAIAFWLNPPAGLLLLLSFIFGGSQSGWTAYP
PLSLVTAPTAQTLWILAIVLVGTSSILGSVNFVVTILMMKVPSMKWDQLPLFCWAILATSVLALLSTPVLAAGLVLLLFD
LNFGTSFFKPDAGGNVVIYQHLFWFYSHPAVYLMILPIFGIMSEVIPVHARKPIFGYKAIAYSSVAICVVGLFVWVHHMF
TSGTPGWMRMFFTISTLIVAVPTGVKIFGWVATLWGGKIRFTSAMLFAIGLLSMFVMGGLSGVTMGTAPFDVHVHDTYYV
VAHFHYVLFGGSVFGIYAGIYHWFPKMTGRKLGEGWGRIHFALTLVGTNLTFLPMHKLGLQGMPRRVAMYDPQFVDLNVL
CTIGAFILGLSVIPFAINVIWSWSKGELAGDNPWEALSLEWTTSSPPLVENWEVLPVVTHGPYDYGHSLEAAPEVSVST
>Mature_558_residues
TRVEFPPHIPPDDNQPKNLAVGHGLTLPAWKWRDYFTFNVDHKVIGIQYLVTAFLFYLIGGLMAIAIRTELATPDADFID
PNLYNAFMTNHGTIMIFLWIVPSAIGGFGNYLIPLMIGARDMAFPKLNAIAFWLNPPAGLLLLLSFIFGGSQSGWTAYPP
LSLVTAPTAQTLWILAIVLVGTSSILGSVNFVVTILMMKVPSMKWDQLPLFCWAILATSVLALLSTPVLAAGLVLLLFDL
NFGTSFFKPDAGGNVVIYQHLFWFYSHPAVYLMILPIFGIMSEVIPVHARKPIFGYKAIAYSSVAICVVGLFVWVHHMFT
SGTPGWMRMFFTISTLIVAVPTGVKIFGWVATLWGGKIRFTSAMLFAIGLLSMFVMGGLSGVTMGTAPFDVHVHDTYYVV
AHFHYVLFGGSVFGIYAGIYHWFPKMTGRKLGEGWGRIHFALTLVGTNLTFLPMHKLGLQGMPRRVAMYDPQFVDLNVLC
TIGAFILGLSVIPFAINVIWSWSKGELAGDNPWEALSLEWTTSSPPLVENWEVLPVVTHGPYDYGHSLEAAPEVSVST

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=506, Percent_Identity=44.4664031620553, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1786634, Length=516, Percent_Identity=40.1162790697674, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6226519, Length=463, Percent_Identity=45.5723542116631, Blast_Score=403, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6226524, Length=319, Percent_Identity=44.5141065830721, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=41.3654618473896, Blast_Score=173, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61655; Mature: 61524

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVEFPPHIPPDDNQPKNLAVGHGLTLPAWKWRDYFTFNVDHKVIGIQYLVTAFLFYLI
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCEEEEECCCEEHHHHHHHHHHHHHHH
GGLMAIAIRTELATPDADFIDPNLYNAFMTNHGTIMIFLWIVPSAIGGFGNYLIPLMIGA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHCCC
RDMAFPKLNAIAFWLNPPAGLLLLLSFIFGGSQSGWTAYPPLSLVTAPTAQTLWILAIVL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCEEECCCHHHHHHHHHHH
VGTSSILGSVNFVVTILMMKVPSMKWDQLPLFCWAILATSVLALLSTPVLAAGLVLLLFD
HCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
LNFGTSFFKPDAGGNVVIYQHLFWFYSHPAVYLMILPIFGIMSEVIPVHARKPIFGYKAI
CCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AYSSVAICVVGLFVWVHHMFTSGTPGWMRMFFTISTLIVAVPTGVKIFGWVATLWGGKIR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
FTSAMLFAIGLLSMFVMGGLSGVTMGTAPFDVHVHDTYYVVAHFHYVLFGGSVFGIYAGI
HHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCEEEEHHHHHHHHCCHHHHHHHHH
YHWFPKMTGRKLGEGWGRIHFALTLVGTNLTFLPMHKLGLQGMPRRVAMYDPQFVDLNVL
HHHHHHHCCCHHCCCCCEEEEEEEEEECCEEEEEHHHHCCCCCCCEEEECCCCEECHHHH
CTIGAFILGLSVIPFAINVIWSWSKGELAGDNPWEALSLEWTTSSPPLVENWEVLPVVTH
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEC
GPYDYGHSLEAAPEVSVST
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRVEFPPHIPPDDNQPKNLAVGHGLTLPAWKWRDYFTFNVDHKVIGIQYLVTAFLFYLI
CCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCEEEEECCCEEHHHHHHHHHHHHHHH
GGLMAIAIRTELATPDADFIDPNLYNAFMTNHGTIMIFLWIVPSAIGGFGNYLIPLMIGA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHCCC
RDMAFPKLNAIAFWLNPPAGLLLLLSFIFGGSQSGWTAYPPLSLVTAPTAQTLWILAIVL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCEEECCCHHHHHHHHHHH
VGTSSILGSVNFVVTILMMKVPSMKWDQLPLFCWAILATSVLALLSTPVLAAGLVLLLFD
HCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
LNFGTSFFKPDAGGNVVIYQHLFWFYSHPAVYLMILPIFGIMSEVIPVHARKPIFGYKAI
CCCCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AYSSVAICVVGLFVWVHHMFTSGTPGWMRMFFTISTLIVAVPTGVKIFGWVATLWGGKIR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
FTSAMLFAIGLLSMFVMGGLSGVTMGTAPFDVHVHDTYYVVAHFHYVLFGGSVFGIYAGI
HHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCEEEEHHHHHHHHCCHHHHHHHHH
YHWFPKMTGRKLGEGWGRIHFALTLVGTNLTFLPMHKLGLQGMPRRVAMYDPQFVDLNVL
HHHHHHHCCCHHCCCCCEEEEEEEEEECCEEEEEHHHHCCCCCCCEEEECCCCEECHHHH
CTIGAFILGLSVIPFAINVIWSWSKGELAGDNPWEALSLEWTTSSPPLVENWEVLPVVTH
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEC
GPYDYGHSLEAAPEVSVST
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]