Click here to switch to the map view.

The map label for this gene is hofD [H]

Identifier: 17228810

GI number: 17228810

Start: 1559149

End: 1559958

Strand: Direct

Name: hofD [H]

Synonym: alr1315

Alternate gene names: 17228810

Gene position: 1559149-1559958 (Clockwise)

Preceding gene: 17228809

Following gene: 17228815

Centisome position: 24.31

GC content: 43.7

Gene sequence:

>810_bases
ATGGAAACTTTGATAGTAACCCTGGCGAGTGTGTTCGTTTTCGCCTTGGGTGCATCTATTGGCAGCTTTATTAATGTTGT
AGTTTATCGGTTACCGGCGGGATTATCAATTCTGTGGCCGCCCTCTCGTTGTCCTCATTGTCTAAACCAGCTCAAAGCTT
ATGATAATGTGCCTGTGCTGGGCTGGATTTGGTTAAAAGGGCGTTGTCGTTTTTGTAAAAATCCGATTTCCATAAGATAC
CCTGTAGTGGAAGCAGTGACAGGGATAATTTTTCTTTGCGTATTTTTGATATTTAAAGTTTCAATTCTGACCTTAGGATA
CTGGACATTTTGCGGCTGGCTATTAGCATTGTCCCTAATTGATTTAGATACTATGACCCTACCTAATCCCCTCACTAAAT
CAGGATTGGTCTTGGGTTTGGTGTTTCAAATGATTGTTGGCTATGCTGCTGACCCTACTTTGTCAGGATTAATTAGACAC
TTAATGATGGGTATCGTTGGCGCTGTTTTGGGTTTATGGTTATTTGAGGCGATCGCTCTTTTAGGGGTTGTCTTCCAAAA
AGAAGCAATGGGTGCAGGAGATGCCAAGCTTGCTGCCATGATGGGTGCTTGGTTGGGTTGGCGATACTTACTTCTGGCTG
GATTGATTGCCTGTACCTTAGGCGCATTGGTAGGTGTTGGGGCTATCCTGCTCTCAAAACGCAAATGGGGGCAAAAAATC
CCCTTTGGCCCTTTTCTCGCCTCAGGAGCTTTGATCACCCTCTTTGGTGGACAACCAATCTTGTCTGCTTATTTACAGTT
GTTTTTTTAA

Upstream 100 bases:

>100_bases
AGTCAATTGTCAGTTGTCAGTTGTTAGTTGTTAGTTGTAGCGCTCGACAATCAGCGAAAAATCAACGACAAATGACACAG
GACTCAAGACAATTGACTAT

Downstream 100 bases:

>100_bases
GATCAGAACCCCGACTTCTTCAAGAAATCGGGGTTCTAAATAAAGTCTGTCAACAGTCACCCGTCAACCGTCAACAGCTA
TAATCTCAAACAATCTACCC

Product: type 4 prepilin peptidase

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
METLIVTLASVFVFALGASIGSFINVVVYRLPAGLSILWPPSRCPHCLNQLKAYDNVPVLGWIWLKGRCRFCKNPISIRY
PVVEAVTGIIFLCVFLIFKVSILTLGYWTFCGWLLALSLIDLDTMTLPNPLTKSGLVLGLVFQMIVGYAADPTLSGLIRH
LMMGIVGAVLGLWLFEAIALLGVVFQKEAMGAGDAKLAAMMGAWLGWRYLLLAGLIACTLGALVGVGAILLSKRKWGQKI
PFGPFLASGALITLFGGQPILSAYLQLFF

Sequences:

>Translated_269_residues
METLIVTLASVFVFALGASIGSFINVVVYRLPAGLSILWPPSRCPHCLNQLKAYDNVPVLGWIWLKGRCRFCKNPISIRY
PVVEAVTGIIFLCVFLIFKVSILTLGYWTFCGWLLALSLIDLDTMTLPNPLTKSGLVLGLVFQMIVGYAADPTLSGLIRH
LMMGIVGAVLGLWLFEAIALLGVVFQKEAMGAGDAKLAAMMGAWLGWRYLLLAGLIACTLGALVGVGAILLSKRKWGQKI
PFGPFLASGALITLFGGQPILSAYLQLFF
>Mature_269_residues
METLIVTLASVFVFALGASIGSFINVVVYRLPAGLSILWPPSRCPHCLNQLKAYDNVPVLGWIWLKGRCRFCKNPISIRY
PVVEAVTGIIFLCVFLIFKVSILTLGYWTFCGWLLALSLIDLDTMTLPNPLTKSGLVLGLVFQMIVGYAADPTLSGLIRH
LMMGIVGAVLGLWLFEAIALLGVVFQKEAMGAGDAKLAAMMGAWLGWRYLLLAGLIACTLGALVGVGAILLSKRKWGQKI
PFGPFLASGALITLFGGQPILSAYLQLFF

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=258, Percent_Identity=35.2713178294574, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 29127; Mature: 29127

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLIVTLASVFVFALGASIGSFINVVVYRLPAGLSILWPPSRCPHCLNQLKAYDNVPVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCEE
GWIWLKGRCRFCKNPISIRYPVVEAVTGIIFLCVFLIFKVSILTLGYWTFCGWLLALSLI
EEEEECCCHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDTMTLPNPLTKSGLVLGLVFQMIVGYAADPTLSGLIRHLMMGIVGAVLGLWLFEAIAL
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVVFQKEAMGAGDAKLAAMMGAWLGWRYLLLAGLIACTLGALVGVGAILLSKRKWGQKI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PFGPFLASGALITLFGGQPILSAYLQLFF
CCCHHHHCCCEEEEECCCHHHHHHHHHHC
>Mature Secondary Structure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CCCHHHHCCCEEEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]