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The map label for this gene is clpP [H]

Identifier: 17228733

GI number: 17228733

Start: 1470240

End: 1470854

Strand: Direct

Name: clpP [H]

Synonym: alr1238

Alternate gene names: 17228733

Gene position: 1470240-1470854 (Clockwise)

Preceding gene: 17228731

Following gene: 17228735

Centisome position: 22.92

GC content: 45.85

Gene sequence:

>615_bases
ATGACTATTCCTATCGTTATTGAACAATCAGGTCGAGGCGAACGCGCCTTTGATATTTACTCACGGCTATTACGTGAGCG
GATTGTCTTTTTGGGTCAACAGGTTGACAGCAACTTGGCTAACTTAATTGTTGCTCAGTTACTGTTTCTAGATGCGGAAG
ACCCAGAGAAAGATATTTATTTGTATATAAATTCTCCTGGTGGTTCGGTAACTGCTGGTATGGGAATTTTTGACACCATG
AAGCACATCCGCCCTGATGTTTGTACCATCTGTACAGGATTGGCGGCAAGTATGGGTGCTTTTCTCCTTAGTGCTGGGGC
TAAAGGTAAGCGCATGAGTCTACCCCATTCGCGGATTATGATTCACCAACCTCTAGGCGGCGCTCAAGGTCAAGCAACTG
ATATTGAAATTCAGGCGCGAGAAATCCTTTACCACAAGCGGCGGTTAAATGATTACTTAGCCGAACACACTGGTCAACCC
ATTGAGCGCATTGCCGAAGATACTGAACGTGACTTTTTCATGTCACCAGATGAAGCCAAAGATTACGGCTTAATTGACCA
AGTAATTGACCGTCACGCTGCTGGTAGTCGTCCAGTGGCGATGGTTGGTCAGTAG

Upstream 100 bases:

>100_bases
GAAACAGGGAGTAAATGTCATTCCCAATACCCAATACCCAATACCCAATACCCAATACCCAATTGATAAGATGGATGTAA
ATTAGCTACAAGCACGCTGC

Downstream 100 bases:

>100_bases
TCAATAGTCAGTTGTGTTTCATGTGGTTTAACGTGAGTTAGACGGAACCTAACCCCAACCCCTTCCCTACAAGGGAAGGC
TGCTCAAAACCCATAACTGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MTIPIVIEQSGRGERAFDIYSRLLRERIVFLGQQVDSNLANLIVAQLLFLDAEDPEKDIYLYINSPGGSVTAGMGIFDTM
KHIRPDVCTICTGLAASMGAFLLSAGAKGKRMSLPHSRIMIHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQP
IERIAEDTERDFFMSPDEAKDYGLIDQVIDRHAAGSRPVAMVGQ

Sequences:

>Translated_204_residues
MTIPIVIEQSGRGERAFDIYSRLLRERIVFLGQQVDSNLANLIVAQLLFLDAEDPEKDIYLYINSPGGSVTAGMGIFDTM
KHIRPDVCTICTGLAASMGAFLLSAGAKGKRMSLPHSRIMIHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQP
IERIAEDTERDFFMSPDEAKDYGLIDQVIDRHAAGSRPVAMVGQ
>Mature_203_residues
TIPIVIEQSGRGERAFDIYSRLLRERIVFLGQQVDSNLANLIVAQLLFLDAEDPEKDIYLYINSPGGSVTAGMGIFDTMK
HIRPDVCTICTGLAASMGAFLLSAGAKGKRMSLPHSRIMIHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQPI
ERIAEDTERDFFMSPDEAKDYGLIDQVIDRHAAGSRPVAMVGQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=58.8235294117647, Blast_Score=232, Evalue=2e-61,
Organism=Escherichia coli, GI1786641, Length=187, Percent_Identity=69.5187165775401, Blast_Score=279, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=196, Percent_Identity=54.5918367346939, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=55.3191489361702, Blast_Score=223, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22570; Mature: 22439

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPIVIEQSGRGERAFDIYSRLLRERIVFLGQQVDSNLANLIVAQLLFLDAEDPEKDIY
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LYINSPGGSVTAGMGIFDTMKHIRPDVCTICTGLAASMGAFLLSAGAKGKRMSLPHSRIM
EEEECCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQPIERIAEDTERDFFMSPDEAK
EECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
DYGLIDQVIDRHAAGSRPVAMVGQ
CCHHHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure 
TIPIVIEQSGRGERAFDIYSRLLRERIVFLGQQVDSNLANLIVAQLLFLDAEDPEKDIY
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LYINSPGGSVTAGMGIFDTMKHIRPDVCTICTGLAASMGAFLLSAGAKGKRMSLPHSRIM
EEEECCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQPIERIAEDTERDFFMSPDEAK
EECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
DYGLIDQVIDRHAAGSRPVAMVGQ
CCHHHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA