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The map label for this gene is zam [H]

Identifier: 17228735

GI number: 17228735

Start: 1473004

End: 1475355

Strand: Direct

Name: zam [H]

Synonym: alr1240

Alternate gene names: 17228735

Gene position: 1473004-1475355 (Clockwise)

Preceding gene: 17228733

Following gene: 17228736

Centisome position: 22.97

GC content: 44.81

Gene sequence:

>2352_bases
ATGGAATTTTCAATCGCTACACTCCTTGCCAATTTCACCGATGATAAATTGGTGGCTCGCAAAGTTTTGGAAAAGAAACT
GGGATGCGAGGACGAAGACAGTTTAGAAAAACTCCACATCGCCTTGGAAGTGCTGGAGAGAATTGGGGTTTTGGCAAAAG
AACGCGGGAAGTATCGCCGCATTTCCGAAGAAGGGATGATCGAAGCAAAGCTACGTTGTTCTAGTAAAGGCTTTTGCTTT
GCCATTCAAGATGTGGAAGGGGCTGAGGATATTTATATTCGTGAAAGTCATCTGAGTAATACTTGGAATGGCGATCGCGT
GTTGGTACGTGTTCTCAAAGAAGGCAGTCGTCGCCGTTCTCCTGAAGGAGAAGTTAAGCTGATTTTGGAACGTTCCAATC
ACACTTTACTGGCACGGATTAAACAAGTAGAAGGCGGTTTTCGTGCTGTCCCTCTGGATGACCGACTGCTGTTTGAGTTG
AAAATTCAAGCCAACAAACTCAAGCTAGAAGAGGCAATTGATCACCTCGCCCACGTCGAAGTCCTGCGTTATCCTCTAGC
CCAATATCCGCCAGTGGGTCGTGTAGTCCAAATTCTGGGCAGCGATGCGGAGGCGGCGGCTGATATAGATTTAGTTACCT
GTAAACATGATTTATCACGTAATTTCCCTGAGTCAATATTAGATGCAGCCGCTAAGTTACCCAAAAGGCTACTCAAAGCA
GACCTAAAAAATAAACTAGATTTACGCAATCTATTTACCTTTACTATTACTGGCATCAATAGCGACACTAAGGTAATAGA
AAATGCCATTAGTTTAGAAAAAACAATAGCTGGCAATTGGCAATTAGGTTTTCATATTGCTGATGTATCTCACTACGTCC
AACCAGATGAACCTTTAGATAGGGAAGCAATCAAACGGGGTCGGTCGGTGTATTTGGGAGACTTGGTATTATCCATGCTA
CCCGATACTGTAGCCGATCGCGCTTCGTTTGTGACTGGGAGCGATCGCCTGGCACTGTCTTTTTTAATTACGATTTCTTC
CCAATTAGGAGAAGTTTTGGAATGGGAAATTCAACCCAGTGTCATTAACGTAGATAACAACGTCAGTAAACAGCAAGCAG
AAGCAATTCTCCAAGGTGCAGCTACTAAAAAAGACTCGCCACAGATTATAGAACGGCTACAAAACTTAACCACTATTGGG
CAAGCCATCAAGGAATCGCGTCTGGCTCGCGGTAGCTTACAGTTAAATCTGCCGTCGAATCAAAACCCTTATTATGATGA
GGGCAGTTTAGGGGCTGTACTAGTGAATGATTCCCCAGTGCGATCGCTGTTGATGGAATTAGTGTTACTAGTTAATGAAT
TAATTGCTACCCATTTGAGTGCTTTAGGTATCCCCGCTATCTGGCGCACTCAAGGCACACCAGATTCGGAAGATGTCCAA
GAAATGCTGAAACTGGCGATTAATTTAGGGGTAGAACTAGCACTAGAACCAGAAGTAGATATCGAACCCTTAGATTATCA
ACAGTTAACCAGGGCTTTTGCTGAGTCTCCCTCAGAGCAGGTGTTAACTTATCTCCTGCAAGATACCCTCAAGCCTGCGG
TGTACAGTACTACCAAAGCCTCTCACTTTGGTTTGGCACTACTACAATACACCCACTTTACAGCCCCTCTACGCCGTTAC
CCAGACTTGCTGATGCAGAGGGTGTATTATCAGCTACTAGAACATGGGCGTGATCGCCGTAACACCAGAGTCAAAGAACG
AGTCAACCTGCGCCACTCCTCCAGCCACTCCGAGATTAACTGGAACGTGTTAGCCCCAGAGTTGCAGCAGGAAATGCAAA
GCGACTTAACTAGGGTGATTATCCAAATCAACGACAGGGAAAAAGAAGTCCAAGAAGCCGAAGCCGATTTAGCTGGACTG
CAAAAAGCCCAACTGATGAAACAGCGCATTGGTCAAGTCTTCCAAGGTGTGATTACTGGCGTACAATCCTACGGTTTCTT
TGTAGAAATCGAAGTTCCAGCCGCCGAAGCTGCAACTAATCCGGGTGTACCTTTGCGGGTGGAAGGGTTAGTACACGTCA
GTTCTCTCAAAGATGACTGGTATGAATACCGCGCCAGACAACAGGCACTATTTGGCAGAAAAAATCGCGCTTCTTATAGA
TTAGGCGATCGGGTTTCCGTACAAGTCAAGAGCGTCGATTACTATCGCCAGCAAATCGATTTAGTCACTGTTGGTAGTGA
TGGCTTAGTTAAAAATTTAGGTGTCGGTAATGTCAATGGTGATATTTCCGATATTTACCTACCAAACGACATGGAATCAG
ATGATTTAGACTCTTATGCAGATGAAGAATAA

Upstream 100 bases:

>100_bases
GGTAATTCGTGTCCAGCTAGTATCCGTAAGCCGTGAGGGTATACGGCAAAGAACCAAATTCAAGCAAAAATGATGTTTTG
ACCAAAGGTCGGTTCACTGC

Downstream 100 bases:

>100_bases
ATTTTGTTAAGTATCTGGTGTCACAACATAACAAACCTCTGATTATCGGCGTATCAGGAGCATCTGGACTGATTTACGCC
GTCCGCGCCCTTAAATATCT

Product: Zam protein

Products: tetrahydrofolate; N-formylmethionyl-tRNA(fMet)

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRRISEEGMIEAKLRCSSKGFCF
AIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRSPEGEVKLILERSNHTLLARIKQVEGGFRAVPLDDRLLFEL
KIQANKLKLEEAIDHLAHVEVLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESILDAAAKLPKRLLKA
DLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLDREAIKRGRSVYLGDLVLSML
PDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPSVINVDNNVSKQQAEAILQGAATKKDSPQIIERLQNLTTIG
QAIKESRLARGSLQLNLPSNQNPYYDEGSLGAVLVNDSPVRSLLMELVLLVNELIATHLSALGIPAIWRTQGTPDSEDVQ
EMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLLQDTLKPAVYSTTKASHFGLALLQYTHFTAPLRRY
PDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEINWNVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGL
QKAQLMKQRIGQVFQGVITGVQSYGFFVEIEVPAAEAATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYR
LGDRVSVQVKSVDYYRQQIDLVTVGSDGLVKNLGVGNVNGDISDIYLPNDMESDDLDSYADEE

Sequences:

>Translated_783_residues
MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRRISEEGMIEAKLRCSSKGFCF
AIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRSPEGEVKLILERSNHTLLARIKQVEGGFRAVPLDDRLLFEL
KIQANKLKLEEAIDHLAHVEVLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESILDAAAKLPKRLLKA
DLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLDREAIKRGRSVYLGDLVLSML
PDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPSVINVDNNVSKQQAEAILQGAATKKDSPQIIERLQNLTTIG
QAIKESRLARGSLQLNLPSNQNPYYDEGSLGAVLVNDSPVRSLLMELVLLVNELIATHLSALGIPAIWRTQGTPDSEDVQ
EMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLLQDTLKPAVYSTTKASHFGLALLQYTHFTAPLRRY
PDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEINWNVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGL
QKAQLMKQRIGQVFQGVITGVQSYGFFVEIEVPAAEAATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYR
LGDRVSVQVKSVDYYRQQIDLVTVGSDGLVKNLGVGNVNGDISDIYLPNDMESDDLDSYADEE
>Mature_783_residues
MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRRISEEGMIEAKLRCSSKGFCF
AIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRSPEGEVKLILERSNHTLLARIKQVEGGFRAVPLDDRLLFEL
KIQANKLKLEEAIDHLAHVEVLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESILDAAAKLPKRLLKA
DLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLDREAIKRGRSVYLGDLVLSML
PDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPSVINVDNNVSKQQAEAILQGAATKKDSPQIIERLQNLTTIG
QAIKESRLARGSLQLNLPSNQNPYYDEGSLGAVLVNDSPVRSLLMELVLLVNELIATHLSALGIPAIWRTQGTPDSEDVQ
EMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLLQDTLKPAVYSTTKASHFGLALLQYTHFTAPLRRY
PDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEINWNVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGL
QKAQLMKQRIGQVFQGVITGVQSYGFFVEIEVPAAEAATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYR
LGDRVSVQVKSVDYYRQQIDLVTVGSDGLVKNLGVGNVNGDISDIYLPNDMESDDLDSYADEE

Specific function: Not known; control resistance to the carbonic anhydrase inhibitor acetazolamide [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=400, Percent_Identity=27.25, Blast_Score=139, Evalue=2e-32,
Organism=Homo sapiens, GI190014625, Length=400, Percent_Identity=27.25, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI134288890, Length=414, Percent_Identity=23.6714975845411, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI19115966, Length=425, Percent_Identity=23.7647058823529, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI219521928, Length=425, Percent_Identity=23.7647058823529, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI87082383, Length=747, Percent_Identity=27.3092369477912, Blast_Score=274, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI212645896, Length=523, Percent_Identity=23.7093690248566, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17553506, Length=513, Percent_Identity=24.3664717348928, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324552, Length=532, Percent_Identity=25.9398496240602, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320499, Length=423, Percent_Identity=22.9314420803783, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24649634, Length=439, Percent_Identity=26.1958997722096, Blast_Score=139, Evalue=9e-33,
Organism=Drosophila melanogaster, GI19922976, Length=391, Percent_Identity=26.8542199488491, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24654597, Length=391, Percent_Identity=26.8542199488491, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24654592, Length=393, Percent_Identity=26.972010178117, Blast_Score=127, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 2.1.2.9

Molecular weight: Translated: 87859; Mature: 87859

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRR
CCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHC
ISEEGMIEAKLRCSSKGFCFAIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRS
CCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCC
PEGEVKLILERSNHTLLARIKQVEGGFRAVPLDDRLLFELKIQANKLKLEEAIDHLAHVE
CCCCEEEEEECCCCHHHHHHHHHCCCCEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHH
VLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESILDAAAKLPKRLLKA
HHHHHHHHCCCHHHHHHHHCCCCHHHCCCEEEECCHHHCCCCHHHHHHHHHHHHHHHHHH
DLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLD
HHHCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCCCCCCCC
REAIKRGRSVYLGDLVLSMLPDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPS
HHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECCCC
VINVDNNVSKQQAEAILQGAATKKDSPQIIERLQNLTTIGQAIKESRLARGSLQLNLPSN
EEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
QNPYYDEGSLGAVLVNDSPVRSLLMELVLLVNELIATHLSALGIPAIWRTQGTPDSEDVQ
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
EMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLLQDTLKPAVYSTTKA
HHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCC
SHFGLALLQYTHFTAPLRRYPDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEE
WNVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGLQKAQLMKQRIGQVFQGVITG
EEEECHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQSYGFFVEIEVPAAEAATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYR
HHHCCEEEEEECCHHHCCCCCCCCEEEECEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEE
LGDRVSVQVKSVDYYRQQIDLVTVGSDGLVKNLGVGNVNGDISDIYLPNDMESDDLDSYA
CCCEEEEEEEHHHHHHHHEEEEEECCCCCHHCCCCCCCCCCCCEEECCCCCCCCCCCCCC
DEE
CCC
>Mature Secondary Structure
MEFSIATLLANFTDDKLVARKVLEKKLGCEDEDSLEKLHIALEVLERIGVLAKERGKYRR
CCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHC
ISEEGMIEAKLRCSSKGFCFAIQDVEGAEDIYIRESHLSNTWNGDRVLVRVLKEGSRRRS
CCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCC
PEGEVKLILERSNHTLLARIKQVEGGFRAVPLDDRLLFELKIQANKLKLEEAIDHLAHVE
CCCCEEEEEECCCCHHHHHHHHHCCCCEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHH
VLRYPLAQYPPVGRVVQILGSDAEAAADIDLVTCKHDLSRNFPESILDAAAKLPKRLLKA
HHHHHHHHCCCHHHHHHHHCCCCHHHCCCEEEECCHHHCCCCHHHHHHHHHHHHHHHHHH
DLKNKLDLRNLFTFTITGINSDTKVIENAISLEKTIAGNWQLGFHIADVSHYVQPDEPLD
HHHCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCCCCCCCC
REAIKRGRSVYLGDLVLSMLPDTVADRASFVTGSDRLALSFLITISSQLGEVLEWEIQPS
HHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECCCC
VINVDNNVSKQQAEAILQGAATKKDSPQIIERLQNLTTIGQAIKESRLARGSLQLNLPSN
EEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
QNPYYDEGSLGAVLVNDSPVRSLLMELVLLVNELIATHLSALGIPAIWRTQGTPDSEDVQ
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
EMLKLAINLGVELALEPEVDIEPLDYQQLTRAFAESPSEQVLTYLLQDTLKPAVYSTTKA
HHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCC
SHFGLALLQYTHFTAPLRRYPDLLMQRVYYQLLEHGRDRRNTRVKERVNLRHSSSHSEIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEE
WNVLAPELQQEMQSDLTRVIIQINDREKEVQEAEADLAGLQKAQLMKQRIGQVFQGVITG
EEEECHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQSYGFFVEIEVPAAEAATNPGVPLRVEGLVHVSSLKDDWYEYRARQQALFGRKNRASYR
HHHCCEEEEEECCHHHCCCCCCCCEEEECEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEE
LGDRVSVQVKSVDYYRQQIDLVTVGSDGLVKNLGVGNVNGDISDIYLPNDMESDDLDSYA
CCCEEEEEEEHHHHHHHHEEEEEECCCCCHHCCCCCCCCCCCCEEECCCCCCCCCCCCCC
DEE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 10-formyltetrahydrofolate; L-methionyl-tRNA(fMet); H2O

Specific reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7727754; 8905231 [H]