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The map label for this gene is arlS [H]

Identifier: 17228687

GI number: 17228687

Start: 1403811

End: 1405229

Strand: Direct

Name: arlS [H]

Synonym: alr1192

Alternate gene names: 17228687

Gene position: 1403811-1405229 (Clockwise)

Preceding gene: 17228685

Following gene: 17228689

Centisome position: 21.89

GC content: 37.21

Gene sequence:

>1419_bases
GTGAATAACATCAAAAAAAATTGGCTAAATATAGACCCATTTTCACTACAGTTACGCCTAACCGTTGGTATGGCTTCCTT
TTCAGCTTTGGTATTAGGTAGCCTAGCTACCTGGACTAGTTGGAAGATGCAGCAAATTTTAATTGATAGCCATAAAAATG
AGGTAGAACAAATAGCCAAACGACTACCACAAGACGTGCAAATTTATAGCAAGATGATGCAACCTGACACGAGTTTAGAA
AAGGCGATTAATAATTTTGCGAATACTAACACGTTAATATGGTTTAAGAATTCTAACAATAAAATATTATCAAAAACTGA
TAATTTAGATTTATTACCTGACTTTTTGGTAACTAAGTTAATGAACTTGACTCAGATGCCGATTAAAGCACAGGTTTATC
AAGTTAATCAAAACTATTTTGTTTTATGTGGAACTTCTATCAAAATCCAAGGTAAGTTGTTGGGTGAGTTATTTGTAGTC
AAGGATATTACCCGCGAACAAACAATGTTTGTGGTAATGGTGCGTAGTTTATGTATTACTAGTATTCTGGCAATTATTAT
TCTGACTGTAGCGATCGCATTTTATATCAAGCGCTCTTTGCAACCTCTACGCCAACTCAGTCAAATGACTGCTGTGATTT
CCGCCGAAGATTTAGGACAAGCCCAATTATATCTTGATAATGCTCCTAGCGAAGTCAAAGAATTAGCACAAACTTTAACT
ATGCTCTTATCCCGTCTCTCCCAATCTTGGGAACAGGAGCGGGAATTTGTCAGTAATGTTTCTCACGAATTACGTACACC
CTTAACGATTGTACATGGTTATTTACAGAGCGTATTGCGGCGGCAAAATAATTTAACCTCTATTCAACAAGAAGCTTTAG
AAATTGCTGCATCAGAAGCGGAACGGACTATCCGCCTGCTACAAGATTTACTGGATTTAGCAAGAGCCGACAGTGGTTAT
TTATACTTTCAGATGAAAACTTATGTACTGAATGACATAGTTGCAGAAATTGTAGTGATGGCTGAAAAGTATAGCGATCG
CCTAATTACTATCGAGTCAACAATTTTCCCTATTGAAGTGAAAGTAGATTACAGTCGCTTCAAACAAGTATTACTGAATT
TGATTGATAATGCTGTTAAGTATTCTGAAGCTGATACACCCATAATCTTTAACTTAGATCAACTTCAAGACACAGCAATT
ATTCAAGTTTGTGATCAAGGTTACGGTATTCCCTTACAACACCAAGCCCGGATTTTTGAGCGATTTTATCGTATAGATGA
ATCTCGCTCCCAGGCCACTGGCGGCTGTGGTTTGGGTTTATCGATTGTCAAAACGCTGGTAGAGGGTATGGGAGGTAGTG
TCAGCGTGCAATCAAAGTTAGGAGAAGGAAGTATATTTACAATAATTTTACCTAGATAG

Upstream 100 bases:

>100_bases
AATTGTAAATCGGCTATAACTAAAGATGTAGCGGTTAACAGTCAAGTTACATTTAACAGCTTGATTTTATTATTAAAGCC
TTTTTTGCTACTCAAAAACA

Downstream 100 bases:

>100_bases
GCAAAGTATGAATGAATCAATTCAAAATTTAAAATAGCCTACGGCATCTCTTACGTTCGCGGTAGCGTGTCGTAGACAGA
GGCTAACGCCAACAAAATTC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNNIKKNWLNIDPFSLQLRLTVGMASFSALVLGSLATWTSWKMQQILIDSHKNEVEQIAKRLPQDVQIYSKMMQPDTSLE
KAINNFANTNTLIWFKNSNNKILSKTDNLDLLPDFLVTKLMNLTQMPIKAQVYQVNQNYFVLCGTSIKIQGKLLGELFVV
KDITREQTMFVVMVRSLCITSILAIIILTVAIAFYIKRSLQPLRQLSQMTAVISAEDLGQAQLYLDNAPSEVKELAQTLT
MLLSRLSQSWEQEREFVSNVSHELRTPLTIVHGYLQSVLRRQNNLTSIQQEALEIAASEAERTIRLLQDLLDLARADSGY
LYFQMKTYVLNDIVAEIVVMAEKYSDRLITIESTIFPIEVKVDYSRFKQVLLNLIDNAVKYSEADTPIIFNLDQLQDTAI
IQVCDQGYGIPLQHQARIFERFYRIDESRSQATGGCGLGLSIVKTLVEGMGGSVSVQSKLGEGSIFTIILPR

Sequences:

>Translated_472_residues
MNNIKKNWLNIDPFSLQLRLTVGMASFSALVLGSLATWTSWKMQQILIDSHKNEVEQIAKRLPQDVQIYSKMMQPDTSLE
KAINNFANTNTLIWFKNSNNKILSKTDNLDLLPDFLVTKLMNLTQMPIKAQVYQVNQNYFVLCGTSIKIQGKLLGELFVV
KDITREQTMFVVMVRSLCITSILAIIILTVAIAFYIKRSLQPLRQLSQMTAVISAEDLGQAQLYLDNAPSEVKELAQTLT
MLLSRLSQSWEQEREFVSNVSHELRTPLTIVHGYLQSVLRRQNNLTSIQQEALEIAASEAERTIRLLQDLLDLARADSGY
LYFQMKTYVLNDIVAEIVVMAEKYSDRLITIESTIFPIEVKVDYSRFKQVLLNLIDNAVKYSEADTPIIFNLDQLQDTAI
IQVCDQGYGIPLQHQARIFERFYRIDESRSQATGGCGLGLSIVKTLVEGMGGSVSVQSKLGEGSIFTIILPR
>Mature_472_residues
MNNIKKNWLNIDPFSLQLRLTVGMASFSALVLGSLATWTSWKMQQILIDSHKNEVEQIAKRLPQDVQIYSKMMQPDTSLE
KAINNFANTNTLIWFKNSNNKILSKTDNLDLLPDFLVTKLMNLTQMPIKAQVYQVNQNYFVLCGTSIKIQGKLLGELFVV
KDITREQTMFVVMVRSLCITSILAIIILTVAIAFYIKRSLQPLRQLSQMTAVISAEDLGQAQLYLDNAPSEVKELAQTLT
MLLSRLSQSWEQEREFVSNVSHELRTPLTIVHGYLQSVLRRQNNLTSIQQEALEIAASEAERTIRLLQDLLDLARADSGY
LYFQMKTYVLNDIVAEIVVMAEKYSDRLITIESTIFPIEVKVDYSRFKQVLLNLIDNAVKYSEADTPIIFNLDQLQDTAI
IQVCDQGYGIPLQHQARIFERFYRIDESRSQATGGCGLGLSIVKTLVEGMGGSVSVQSKLGEGSIFTIILPR

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=263, Percent_Identity=31.1787072243346, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=32.4444444444444, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786783, Length=494, Percent_Identity=24.0890688259109, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=28.8808664259928, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=28.9036544850498, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=30.3149606299213, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790346, Length=321, Percent_Identity=25.8566978193146, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=28.6919831223629, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=32.2869955156951, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787894, Length=311, Percent_Identity=26.0450160771704, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=28.5067873303167, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=28.3783783783784, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=27.2425249169435, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=222, Percent_Identity=28.3783783783784, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=27.9461279461279, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.5067873303167, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=329, Percent_Identity=25.2279635258359, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=277, Percent_Identity=25.2707581227437, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=25.6666666666667, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53435; Mature: 53435

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIKKNWLNIDPFSLQLRLTVGMASFSALVLGSLATWTSWKMQQILIDSHKNEVEQIAK
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RLPQDVQIYSKMMQPDTSLEKAINNFANTNTLIWFKNSNNKILSKTDNLDLLPDFLVTKL
HCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCHHHHHHHH
MNLTQMPIKAQVYQVNQNYFVLCGTSIKIQGKLLGELFVVKDITREQTMFVVMVRSLCIT
HHHHCCCCEEEEEEECCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILAIIILTVAIAFYIKRSLQPLRQLSQMTAVISAEDLGQAQLYLDNAPSEVKELAQTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
MLLSRLSQSWEQEREFVSNVSHELRTPLTIVHGYLQSVLRRQNNLTSIQQEALEIAASEA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ERTIRLLQDLLDLARADSGYLYFQMKTYVLNDIVAEIVVMAEKYSDRLITIESTIFPIEV
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEEEEE
KVDYSRFKQVLLNLIDNAVKYSEADTPIIFNLDQLQDTAIIQVCDQGYGIPLQHQARIFE
EECHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RFYRIDESRSQATGGCGLGLSIVKTLVEGMGGSVSVQSKLGEGSIFTIILPR
HHHHHCCCHHCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MNNIKKNWLNIDPFSLQLRLTVGMASFSALVLGSLATWTSWKMQQILIDSHKNEVEQIAK
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RLPQDVQIYSKMMQPDTSLEKAINNFANTNTLIWFKNSNNKILSKTDNLDLLPDFLVTKL
HCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCHHHHHHHH
MNLTQMPIKAQVYQVNQNYFVLCGTSIKIQGKLLGELFVVKDITREQTMFVVMVRSLCIT
HHHHCCCCEEEEEEECCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILAIIILTVAIAFYIKRSLQPLRQLSQMTAVISAEDLGQAQLYLDNAPSEVKELAQTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
MLLSRLSQSWEQEREFVSNVSHELRTPLTIVHGYLQSVLRRQNNLTSIQQEALEIAASEA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ERTIRLLQDLLDLARADSGYLYFQMKTYVLNDIVAEIVVMAEKYSDRLITIESTIFPIEV
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEEEEE
KVDYSRFKQVLLNLIDNAVKYSEADTPIIFNLDQLQDTAIIQVCDQGYGIPLQHQARIFE
EECHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RFYRIDESRSQATGGCGLGLSIVKTLVEGMGGSVSVQSKLGEGSIFTIILPR
HHHHHCCCHHCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA