Click here to switch to the map view.

The map label for this gene is accC

Identifier: 17228434

GI number: 17228434

Start: 1092759

End: 1094102

Strand: Direct

Name: accC

Synonym: alr0939

Alternate gene names: 17228434

Gene position: 1092759-1094102 (Clockwise)

Preceding gene: 17228428

Following gene: 17228436

Centisome position: 17.04

GC content: 47.47

Gene sequence:

>1344_bases
ATGAAGTTTGACAAAATATTAATTGCCAATCGGGGAGAAATAGCGCTGCGCATTCTCCGCGCCTGTGAGGAAATGGGGAT
TGCGACGATCGCAGTTCATTCGACTGTTGACCGGAATGCTCTTCATGTCCAACTTGCTGACGAAGCGGTTTGTATTGGCG
AACCTGCTAGCGCTAAAAGTTATTTGAATATTCCCAATATTATTGCTGCGGCTTTAACGCGCAATGCCAGTGCTATTCAT
CCTGGGTATGGCTTTTTATCTGAAAATGCCAAATTTGCGGAAATCTGTGCTGACCATCACATTGCATTCATTGGCCCCAC
CCCAGAAGCTATCCGCCTCATGGGGGACAAATCCACTGCCAAGGAAACCATGCAAAAAGCTGGTGTACCGACAGTACCGG
GTAGTGAAGGTTTGGTAGAGACAGAGCAAGAAGGATTAGAACTGGCGAAAGATATTGGCTACCCAGTGATGATCAAAGCC
ACGGCTGGTGGTGGCGGCCGGGGTATGCGACTGGTGCGATCGCCAGATGAATTTGTCAAACTGTTCTTAGCCGCCCAAGG
TGAAGCTGGTGCAGCCTTTGGTAATGCTGGCGTTTATATAGAAAAATTTATTGAACGTCCGCGCCACATTGAATTTCAAA
TTTTGGCTGATAATTACGGCAATGTGATTCACTTGGGTGAGAGGGATTGCTCAATTCAGCGTCGTAACCAAAAGTTACTA
GAAGAAGCCCCCAGCCCAGCCTTGGACTCAGACCTAAGGGAAAAAATGGGACAAGCGGCGGTGAAAGCGGCTCAGTTTAT
CAATTACACCGGGGCAGGTACTATCGAGTTTTTGCTAGATAGATCCGGTCAGTTTTACTTTATGGAGATGAACACCCGGA
TTCAAGTAGAACATCCCGTAACTGAGATGGTTACTGGAGTGGATTTATTGGTTGAGCAAATCAGAATTGCCCAAGGGGAA
AGACTTAGACTAACTCAAGACCAAGTAGTTTTACGCGGTCATGCGATCGAATGTCGCATCAATGCCGAAGACCCAGACCA
CGATTTCCGCCCAGCACCCGGACGCATTAGCGGTTATCTTCCCCCTGGCGGCCCTGGCGTGCGGATTGACTCCCACGTTT
ACACGGATTACCAAATTCCGCCCTACTACGATTCCTTAATTGGTAAATTGATCGTTTGGGGCCCTGATCGCGCTACTGCT
ATTAACCGCATGAAACGCGCCCTCAGGGAATGCGCCATCACTGGATTACCTACAACCATTGGGTTTCATCAAAGAATTAT
GGAAAATCCCCAATTTTTACAAGGTAATGTGTCTACTAGTTTTGTGCAGGAGATGAATAAATAG

Upstream 100 bases:

>100_bases
AAGCGATGCCTAAGGCGGGCTACGCCTACGCGCTAAAAGCAACTTGGATGGGAGACAATTTCTATCTGCTGGTACTGATA
CTGATATCGAAAACTAGAAA

Downstream 100 bases:

>100_bases
GGTAATGGGTAATGGGTAATGGGTAATAGAGTTTCAATCACCAATTACCAATTCCCTAACTCATCCGTGCCAACATCGTC
AGTAATCCTTGCTGGCCTAG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKSYLNIPNIIAAALTRNASAIH
PGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTAKETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKA
TAGGGGRGMRLVRSPDEFVKLFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLL
EEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPVTEMVTGVDLLVEQIRIAQGE
RLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYLPPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATA
INRMKRALRECAITGLPTTIGFHQRIMENPQFLQGNVSTSFVQEMNK

Sequences:

>Translated_447_residues
MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKSYLNIPNIIAAALTRNASAIH
PGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTAKETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKA
TAGGGGRGMRLVRSPDEFVKLFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLL
EEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPVTEMVTGVDLLVEQIRIAQGE
RLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYLPPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATA
INRMKRALRECAITGLPTTIGFHQRIMENPQFLQGNVSTSFVQEMNK
>Mature_447_residues
MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKSYLNIPNIIAAALTRNASAIH
PGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTAKETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKA
TAGGGGRGMRLVRSPDEFVKLFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLL
EEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPVTEMVTGVDLLVEQIRIAQGE
RLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYLPPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATA
INRMKRALRECAITGLPTTIGFHQRIMENPQFLQGNVSTSFVQEMNK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=50.2252252252252, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=49.8876404494382, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=49.8876404494382, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=49.8876404494382, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=48.5393258426966, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=48.5393258426966, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=48.5393258426966, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=32.0866141732283, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=32.0866141732283, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=32.0866141732283, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=32.0866141732283, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=32.0866141732283, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=31.6205533596838, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=57.5620767494357, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=49.3243243243243, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=47.9820627802691, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=45.5555555555556, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=30.4518664047151, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=30.4518664047151, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=30.3092783505155, Blast_Score=219, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=43.4389140271493, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.7589285714286, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.4285714285714, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324343, Length=520, Percent_Identity=31.5384615384615, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=32.5481798715203, Blast_Score=246, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=47.8555304740406, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=49.7747747747748, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=47.6658476658477, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=31.58953722334, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=31.58953722334, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=31.58953722334, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=31.58953722334, Blast_Score=255, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCC_NOSS1 (Q06862)

Other databases:

- EMBL:   L14862
- EMBL:   BA000019
- PIR:   A53311
- PIR:   AH1923
- RefSeq:   NP_484982.1
- ProteinModelPortal:   Q06862
- SMR:   Q06862
- STRING:   Q06862
- GeneID:   1104533
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr0939
- NMPDR:   fig|103690.1.peg.1249
- eggNOG:   COG0439
- HOGENOM:   HBG535236
- OMA:   ESIAMTK
- PhylomeDB:   Q06862
- ProtClustDB:   PRK08591
- BioCyc:   NSP103690:ALR0939-MONOMER
- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- SMART:   SM00878
- TIGRFAMs:   TIGR00514

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.14; =6.4.1.2

Molecular weight: Translated: 49105; Mature: 49105

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00866 CPSASE_1; PS00867 CPSASE_2

Important sites: ACT_SITE 293-293 BINDING 117-117 BINDING 201-201 BINDING 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKS
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEECCCCCCCC
YLNIPNIIAAALTRNASAIHPGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTA
CCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHEEECCCHHH
KETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKATAGGGGRGMRLVRSPDEFVK
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHH
LFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLL
HHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEEECCH
TEMVTGVDLLVEQIRIAQGERLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYL
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCCEECC
PPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATAINRMKRALRECAITGLPTTI
CCCCCCCEECCEEEECCCCCCHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHH
GFHQRIMENPQFLQGNVSTSFVQEMNK
HHHHHHHCCCCEEECCCHHHHHHHHCC
>Mature Secondary Structure
MKFDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKS
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEECCCCCCCC
YLNIPNIIAAALTRNASAIHPGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTA
CCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHEEECCCHHH
KETMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKATAGGGGRGMRLVRSPDEFVK
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHH
LFLAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLL
HHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSGQFYFMEMNTRIQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEEECCH
TEMVTGVDLLVEQIRIAQGERLRLTQDQVVLRGHAIECRINAEDPDHDFRPAPGRISGYL
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCCEECC
PPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATAINRMKRALRECAITGLPTTI
CCCCCCCEECCEEEECCCCCCHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHH
GFHQRIMENPQFLQGNVSTSFVQEMNK
HHHHHHHCCCCEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840