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The map label for this gene is era [H]

Identifier: 17228407

GI number: 17228407

Start: 1055744

End: 1056757

Strand: Direct

Name: era [H]

Synonym: alr0912

Alternate gene names: 17228407

Gene position: 1055744-1056757 (Clockwise)

Preceding gene: 17228400

Following gene: 17228408

Centisome position: 16.46

GC content: 44.87

Gene sequence:

>1014_bases
GTGTCTAAAGAAAAAACTAAGTTATCCCAGCTAGAAAATATGACGGCGGAACTAAAAGTGGCTAGTATTGATAATCACAT
CTCCTCCTTATCAGGCGAAGTATCAATCCCCCAAGCTCCACCTGAATTTAAATCAGGCTTTATCGGCATTATCGGCCGTC
CTAATGTCGGTAAATCTACTTTGATGAATCAATTAGTAGGGCAAAAAATTGCCATTACCTCACCAGTAGCGCAAACAACA
CGCAATCGTTTGAGAGGAATTGTCACTACACCAGAGGCGCAGTTAATCTTTGTTGATACGCCAGGAATTCACAAACCCCA
TCATCAATTAGGTGAAGTACTGGTGAAAAATGCCAAACTCGCTATTGAATCAGTGGATGTAGTACTGTTTGTTGTCGATG
GTGCAGTGGCTTGTGGTGCAGGCGATCGCTTTATTGCCGATTTACTAATTCATAGCAAAACCCCGGTGATTTTGGGCATC
AATAAAGTAGACCAACAACCCCCCGATTCCCAAAAGATTGATGAGAGCTACCAGCAGTTAGCAAGTGCTTATCAATGGCC
GACGGTAAAATTTTCGGCTAAGACCGGTGCAGAGTTGCCCCAACTACAAGAATTATTAGTAGAGCATTTAGAGCATGGGC
CGTACTATTATCCCCCAGACTTGGTAACAGACCAGCCAGAACGGTTTATTATGGGGGAATTAATCCGAGAGCAGATTTTG
CTGTTGACTCGTGAAGAAGTACCTCATTCAGTAGCGATCGCCATTGATTTAGTCGAAGAAACACCAACTATTACCCGCGT
CCTCGCAACCATCCACGTTGAGCGCGATTCCCAAAAAGGTATTCTCATCGGGAAAGGTGGTTCAATGCTCAAATCCATCG
GTAGCGCAGCCCGCGAGCAAATTCAAAAGCTCATTGCTGGTAAAGTCTATCTAGAGCTATTCGTCAAAGTCCAACCCAAA
TGGCGACACTCCCGCGTCAGACTAGCAGAGTTAGGCTATCGCGTGGAAGAATAG

Upstream 100 bases:

>100_bases
ATCTCATTTTTCGAGATTCAAGCTAAATATATTTACTAGTAGATTAAACTAAAGCAAGGCAGTTCCCCCGAAAATCCCAG
GGTGAATTTATGCGGGTTAT

Downstream 100 bases:

>100_bases
AAAGTTAGTCATTGGTCATCTCTTACAAAGTTCTGTTCGGAGGAAACCTCCGCTCAGACTTTGCGCTTAGTCAACATTCA
AAACAGTTTTGGACTCTGAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSKEKTKLSQLENMTAELKVASIDNHISSLSGEVSIPQAPPEFKSGFIGIIGRPNVGKSTLMNQLVGQKIAITSPVAQTT
RNRLRGIVTTPEAQLIFVDTPGIHKPHHQLGEVLVKNAKLAIESVDVVLFVVDGAVACGAGDRFIADLLIHSKTPVILGI
NKVDQQPPDSQKIDESYQQLASAYQWPTVKFSAKTGAELPQLQELLVEHLEHGPYYYPPDLVTDQPERFIMGELIREQIL
LLTREEVPHSVAIAIDLVEETPTITRVLATIHVERDSQKGILIGKGGSMLKSIGSAAREQIQKLIAGKVYLELFVKVQPK
WRHSRVRLAELGYRVEE

Sequences:

>Translated_337_residues
MSKEKTKLSQLENMTAELKVASIDNHISSLSGEVSIPQAPPEFKSGFIGIIGRPNVGKSTLMNQLVGQKIAITSPVAQTT
RNRLRGIVTTPEAQLIFVDTPGIHKPHHQLGEVLVKNAKLAIESVDVVLFVVDGAVACGAGDRFIADLLIHSKTPVILGI
NKVDQQPPDSQKIDESYQQLASAYQWPTVKFSAKTGAELPQLQELLVEHLEHGPYYYPPDLVTDQPERFIMGELIREQIL
LLTREEVPHSVAIAIDLVEETPTITRVLATIHVERDSQKGILIGKGGSMLKSIGSAAREQIQKLIAGKVYLELFVKVQPK
WRHSRVRLAELGYRVEE
>Mature_336_residues
SKEKTKLSQLENMTAELKVASIDNHISSLSGEVSIPQAPPEFKSGFIGIIGRPNVGKSTLMNQLVGQKIAITSPVAQTTR
NRLRGIVTTPEAQLIFVDTPGIHKPHHQLGEVLVKNAKLAIESVDVVLFVVDGAVACGAGDRFIADLLIHSKTPVILGIN
KVDQQPPDSQKIDESYQQLASAYQWPTVKFSAKTGAELPQLQELLVEHLEHGPYYYPPDLVTDQPERFIMGELIREQILL
LTREEVPHSVAIAIDLVEETPTITRVLATIHVERDSQKGILIGKGGSMLKSIGSAAREQIQKLIAGKVYLELFVKVQPKW
RHSRVRLAELGYRVEE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=331, Percent_Identity=26.2839879154079, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=39.4557823129252, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI87082120, Length=137, Percent_Identity=34.3065693430657, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367268, Length=121, Percent_Identity=37.1900826446281, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646434, Length=312, Percent_Identity=26.2820512820513, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 37188; Mature: 37056

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEKTKLSQLENMTAELKVASIDNHISSLSGEVSIPQAPPEFKSGFIGIIGRPNVGKST
CCCHHHHHHHHHCCHHHEEEEHHHHHHHHCCCCEECCCCCHHHHCCEEEEEECCCCCHHH
LMNQLVGQKIAITSPVAQTTRNRLRGIVTTPEAQLIFVDTPGIHKPHHQLGEVLVKNAKL
HHHHHHCCEEEECCHHHHHHHHHHCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
AIESVDVVLFVVDGAVACGAGDRFIADLLIHSKTPVILGINKVDQQPPDSQKIDESYQQL
EEEHHEEEEEEECCCEEECCCHHHHHHHHHCCCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASAYQWPTVKFSAKTGAELPQLQELLVEHLEHGPYYYPPDLVTDQPERFIMGELIREQIL
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLTREEVPHSVAIAIDLVEETPTITRVLATIHVERDSQKGILIGKGGSMLKSIGSAAREQ
HHHHHCCCCEEEEEEEEHHCCHHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHHHH
IQKLIAGKVYLELFVKVQPKWRHSRVRLAELGYRVEE
HHHHHHHHHEEHHHEEECCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKEKTKLSQLENMTAELKVASIDNHISSLSGEVSIPQAPPEFKSGFIGIIGRPNVGKST
CCHHHHHHHHHCCHHHEEEEHHHHHHHHCCCCEECCCCCHHHHCCEEEEEECCCCCHHH
LMNQLVGQKIAITSPVAQTTRNRLRGIVTTPEAQLIFVDTPGIHKPHHQLGEVLVKNAKL
HHHHHHCCEEEECCHHHHHHHHHHCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
AIESVDVVLFVVDGAVACGAGDRFIADLLIHSKTPVILGINKVDQQPPDSQKIDESYQQL
EEEHHEEEEEEECCCEEECCCHHHHHHHHHCCCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASAYQWPTVKFSAKTGAELPQLQELLVEHLEHGPYYYPPDLVTDQPERFIMGELIREQIL
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLTREEVPHSVAIAIDLVEETPTITRVLATIHVERDSQKGILIGKGGSMLKSIGSAAREQ
HHHHHCCCCEEEEEEEEHHCCHHHHHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHHHH
IQKLIAGKVYLELFVKVQPKWRHSRVRLAELGYRVEE
HHHHHHHHHEEHHHEEECCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]