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The map label for this gene is prlC [H]

Identifier: 17228375

GI number: 17228375

Start: 1014604

End: 1016712

Strand: Direct

Name: prlC [H]

Synonym: alr0880

Alternate gene names: 17228375

Gene position: 1014604-1016712 (Clockwise)

Preceding gene: 17228372

Following gene: 17228377

Centisome position: 15.82

GC content: 47.27

Gene sequence:

>2109_bases
ATGAGTGCGAATACTACCATCACTGATAATCCCTTACTTAAAGGTTCTGGCTTGCCTCCATTTACGGAAATTCAACCAGA
ACAAGTACAACCAGCCTTTCAACAACTATTGGCGGAACTGGAACAAGAACTGACTACCTTAGAGGCAAATGTACAGCCTA
CTTGGGATGGCTTGGTCGAACCTTTAGAAAAGTTAAGCGATCGCCTGACCTGGAGTTGGGGTATAGTAAATCATCTAGTG
GGTGTGAAAAATAGCCCAAAACTACGTGTAGCCCATGAAGCTGTACAACCACAAGTAGTACAATTTATCAACAAGTTGGG
ACAAAGCCAACCCATCTACAACGCTTTTAAAGAACTCCGCGCCAGCGATAGTTGGAAAACGCTCGACTCAGCCCAACAAA
GAATTGTGGAAGCAGCTATTCGGGATGCTGAACTATCCGGTGTGGGCTTGCAAGGAGAAGCGCGGGAACGTTTCAATGCC
ATTCAAATGGAATTAGCAGAACTGGCTACCAAGTTCTCTAACCACGTCCTCGATGCAACTACAGCCTTTAGTCTCACCCT
CACCACTAAAGCGGAAGTTGACGGTTTACCCCAAAGTTTACTTAGTTTAGCAGCACAAGCAGCACGGGCAGCTGGTGCAG
AAAACGCCACACCAGAAAATGGCCCTTGGCGCATTACTTTAGATATTCCCAGTTATAGCCCCTTCATGCAGCACAGCACC
AGACGTGATTTGCGCGAAAAGCTTTACAAAACTTATATTACCCGCGCCTCATCTGATGAATTAGATAACAACCCCATCAT
TGAACGGACTTTAGAGTTACGCCAAGAACTGGCAAACTTATTGGGTTTCCAAAATTATGCCGAGTTGAGCCTAGCCAGTA
AAATGGCTCCCAACGTGGAAGCGGTTGAAGCACTATTAGAAGAATTACGCAGCGCTAGTTACGATGCAGCCGTTAAAGAC
TTAGAAGCCTTGAAAGCCTTTGCAGCCTCCAAGGGAGCGCCAGAAGCCGCAGACTTACGACACTGGGATATTAGTTTTTG
GGCTGAACGCCAACGAGAAGAAAAATTTGCCTTCACCGCCGAAGAACTACGTCCTTACTTTCCCCTACCCCAAGTCCTCG
ATGGCTTATTTGCACTGGTGCATCGGTTGTTTGGCATCACTGTTACCCCGGCAGATGGCCAAGCCCCAGTTTGGCACAAA
GATATCCGTTATTTCCAAATAGCTGATGAAACGGGTAGCCCCATCGCCTATTTCTACCTAGACCCCTACAGTCGTCCCGC
CGAAAAGCGTGGCGGTGCATGGATGGATACCTGCATCAATCGCGCCATCATCACAGAAAATGGTGTAACAACTGTGCGTT
TACCTGTGGCTTATTTGGTATGTAACCAAACTCCGCCAGTGGACGGTAAACCTAGTTTGATGACATTCTATGAAGTAGAA
ACCCTGTTCCATGAATTTGGTCATGGGCTACATCATATGCTCACCAAGGTTAACTACACTGGAGCCGCAGGCATCAACAA
TGTAGAGTGGGATGCGGTAGAACTACCAAGTCAATTTATGGAAAACTGGTGTTATGAACGCACCACGTTATTTAGCTTGG
CTAAACATTACCAAACTGGGGAAACTCTACCAGAACATTATTATCAAAAACTCCTAGCCGCCCGCAATTATATGAGTGGT
AGCGGTATCTTGCGCCAACTCCACTTTAGCAGCGTTGATTTGGAATTACACTCCCGCTATCGCCCAGGTGGTCAGGAAAC
CGCCGCCGATGTGCGTCATCGAGTTGCCCAAAAGACTACTGTCTTACCACCACTACCAGAAGACGCTTTTCTCTGCGCTT
TTGGACATATCTTTGCAGGTGGTTATGCTGCTGGCTATTACAGTTACAAGTGGGCAGAGGTACTAAGTGCTGATGCTTTC
GCAGCTTTTGAAGATGCTGGGCTGGAAGATGAAGCCGCCATTAAAGCTACAGGTAGGCGTTATCGGGATACGGTGTTAGC
TCTTGGTGGTAGCAAGCATCCGATGGAGGTATTTGCAGCGTTCCGAGGACGGGAACCGAGTACAACTTCTTTGCTCAAGC
ATAATGGATTGCTGCCAAATGCTGCTTAA

Upstream 100 bases:

>100_bases
ACAAGATTGGCGATTTTGGCATTATGGCAGGGCGAAATGGAGCAGCGATCGCTACATTAGTAGAATATAGTTACCCATAA
TCTGCGGCTCACATCAAACC

Downstream 100 bases:

>100_bases
GAAGTGAGGCAAGGAATTTAAACGCAGAGTGACGCAAAGGGTTAAACCGAGGAACGCGGAGAACTTGATACTTCTCTGCG
CCTCTGCCTGAGATGATTTT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 701

Protein sequence:

>702_residues
MSANTTITDNPLLKGSGLPPFTEIQPEQVQPAFQQLLAELEQELTTLEANVQPTWDGLVEPLEKLSDRLTWSWGIVNHLV
GVKNSPKLRVAHEAVQPQVVQFINKLGQSQPIYNAFKELRASDSWKTLDSAQQRIVEAAIRDAELSGVGLQGEARERFNA
IQMELAELATKFSNHVLDATTAFSLTLTTKAEVDGLPQSLLSLAAQAARAAGAENATPENGPWRITLDIPSYSPFMQHST
RRDLREKLYKTYITRASSDELDNNPIIERTLELRQELANLLGFQNYAELSLASKMAPNVEAVEALLEELRSASYDAAVKD
LEALKAFAASKGAPEAADLRHWDISFWAERQREEKFAFTAEELRPYFPLPQVLDGLFALVHRLFGITVTPADGQAPVWHK
DIRYFQIADETGSPIAYFYLDPYSRPAEKRGGAWMDTCINRAIITENGVTTVRLPVAYLVCNQTPPVDGKPSLMTFYEVE
TLFHEFGHGLHHMLTKVNYTGAAGINNVEWDAVELPSQFMENWCYERTTLFSLAKHYQTGETLPEHYYQKLLAARNYMSG
SGILRQLHFSSVDLELHSRYRPGGQETAADVRHRVAQKTTVLPPLPEDAFLCAFGHIFAGGYAAGYYSYKWAEVLSADAF
AAFEDAGLEDEAAIKATGRRYRDTVLALGGSKHPMEVFAAFRGREPSTTSLLKHNGLLPNAA

Sequences:

>Translated_702_residues
MSANTTITDNPLLKGSGLPPFTEIQPEQVQPAFQQLLAELEQELTTLEANVQPTWDGLVEPLEKLSDRLTWSWGIVNHLV
GVKNSPKLRVAHEAVQPQVVQFINKLGQSQPIYNAFKELRASDSWKTLDSAQQRIVEAAIRDAELSGVGLQGEARERFNA
IQMELAELATKFSNHVLDATTAFSLTLTTKAEVDGLPQSLLSLAAQAARAAGAENATPENGPWRITLDIPSYSPFMQHST
RRDLREKLYKTYITRASSDELDNNPIIERTLELRQELANLLGFQNYAELSLASKMAPNVEAVEALLEELRSASYDAAVKD
LEALKAFAASKGAPEAADLRHWDISFWAERQREEKFAFTAEELRPYFPLPQVLDGLFALVHRLFGITVTPADGQAPVWHK
DIRYFQIADETGSPIAYFYLDPYSRPAEKRGGAWMDTCINRAIITENGVTTVRLPVAYLVCNQTPPVDGKPSLMTFYEVE
TLFHEFGHGLHHMLTKVNYTGAAGINNVEWDAVELPSQFMENWCYERTTLFSLAKHYQTGETLPEHYYQKLLAARNYMSG
SGILRQLHFSSVDLELHSRYRPGGQETAADVRHRVAQKTTVLPPLPEDAFLCAFGHIFAGGYAAGYYSYKWAEVLSADAF
AAFEDAGLEDEAAIKATGRRYRDTVLALGGSKHPMEVFAAFRGREPSTTSLLKHNGLLPNAA
>Mature_701_residues
SANTTITDNPLLKGSGLPPFTEIQPEQVQPAFQQLLAELEQELTTLEANVQPTWDGLVEPLEKLSDRLTWSWGIVNHLVG
VKNSPKLRVAHEAVQPQVVQFINKLGQSQPIYNAFKELRASDSWKTLDSAQQRIVEAAIRDAELSGVGLQGEARERFNAI
QMELAELATKFSNHVLDATTAFSLTLTTKAEVDGLPQSLLSLAAQAARAAGAENATPENGPWRITLDIPSYSPFMQHSTR
RDLREKLYKTYITRASSDELDNNPIIERTLELRQELANLLGFQNYAELSLASKMAPNVEAVEALLEELRSASYDAAVKDL
EALKAFAASKGAPEAADLRHWDISFWAERQREEKFAFTAEELRPYFPLPQVLDGLFALVHRLFGITVTPADGQAPVWHKD
IRYFQIADETGSPIAYFYLDPYSRPAEKRGGAWMDTCINRAIITENGVTTVRLPVAYLVCNQTPPVDGKPSLMTFYEVET
LFHEFGHGLHHMLTKVNYTGAAGINNVEWDAVELPSQFMENWCYERTTLFSLAKHYQTGETLPEHYYQKLLAARNYMSGS
GILRQLHFSSVDLELHSRYRPGGQETAADVRHRVAQKTTVLPPLPEDAFLCAFGHIFAGGYAAGYYSYKWAEVLSADAFA
AFEDAGLEDEAAIKATGRRYRDTVLALGGSKHPMEVFAAFRGREPSTTSLLKHNGLLPNAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=622, Percent_Identity=28.4565916398714, Blast_Score=255, Evalue=1e-67,
Organism=Homo sapiens, GI14149738, Length=688, Percent_Identity=25.8720930232558, Blast_Score=226, Evalue=8e-59,
Organism=Homo sapiens, GI156105687, Length=657, Percent_Identity=24.5053272450533, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1789913, Length=698, Percent_Identity=43.9828080229226, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1787819, Length=699, Percent_Identity=30.1859799713877, Blast_Score=279, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71999758, Length=578, Percent_Identity=22.8373702422145, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=679, Percent_Identity=22.2385861561119, Blast_Score=124, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319793, Length=697, Percent_Identity=26.5423242467719, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322715, Length=706, Percent_Identity=23.7960339943343, Blast_Score=160, Evalue=8e-40,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=28.9586305278174, Blast_Score=303, Evalue=4e-82,
Organism=Drosophila melanogaster, GI20129717, Length=653, Percent_Identity=24.0428790199081, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 78182; Mature: 78051

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANTTITDNPLLKGSGLPPFTEIQPEQVQPAFQQLLAELEQELTTLEANVQPTWDGLVE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLEKLSDRLTWSWGIVNHLVGVKNSPKLRVAHEAVQPQVVQFINKLGQSQPIYNAFKELR
HHHHHHHHCEEHHHHHHHHHCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
ASDSWKTLDSAQQRIVEAAIRDAELSGVGLQGEARERFNAIQMELAELATKFSNHVLDAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TAFSLTLTTKAEVDGLPQSLLSLAAQAARAAGAENATPENGPWRITLDIPSYSPFMQHST
CEEEEEEEECHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
RRDLREKLYKTYITRASSDELDNNPIIERTLELRQELANLLGFQNYAELSLASKMAPNVE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
AVEALLEELRSASYDAAVKDLEALKAFAASKGAPEAADLRHWDISFWAERQREEKFAFTA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EELRPYFPLPQVLDGLFALVHRLFGITVTPADGQAPVWHKDIRYFQIADETGSPIAYFYL
HHCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHCCEEEEEECCCCCCEEEEEE
DPYSRPAEKRGGAWMDTCINRAIITENGVTTVRLPVAYLVCNQTPPVDGKPSLMTFYEVE
CCCCCCHHHCCCCHHHHHHCCEEEECCCCEEEEEHEEEEEECCCCCCCCCCCEEHHHHHH
TLFHEFGHGLHHMLTKVNYTGAAGINNVEWDAVELPSQFMENWCYERTTLFSLAKHYQTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETLPEHYYQKLLAARNYMSGSGILRQLHFSSVDLELHSRYRPGGQETAADVRHRVAQKTT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCC
VLPPLPEDAFLCAFGHIFAGGYAAGYYSYKWAEVLSADAFAAFEDAGLEDEAAIKATGRR
CCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHH
YRDTVLALGGSKHPMEVFAAFRGREPSTTSLLKHNGLLPNAA
HHHHHEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SANTTITDNPLLKGSGLPPFTEIQPEQVQPAFQQLLAELEQELTTLEANVQPTWDGLVE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLEKLSDRLTWSWGIVNHLVGVKNSPKLRVAHEAVQPQVVQFINKLGQSQPIYNAFKELR
HHHHHHHHCEEHHHHHHHHHCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
ASDSWKTLDSAQQRIVEAAIRDAELSGVGLQGEARERFNAIQMELAELATKFSNHVLDAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TAFSLTLTTKAEVDGLPQSLLSLAAQAARAAGAENATPENGPWRITLDIPSYSPFMQHST
CEEEEEEEECHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
RRDLREKLYKTYITRASSDELDNNPIIERTLELRQELANLLGFQNYAELSLASKMAPNVE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
AVEALLEELRSASYDAAVKDLEALKAFAASKGAPEAADLRHWDISFWAERQREEKFAFTA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EELRPYFPLPQVLDGLFALVHRLFGITVTPADGQAPVWHKDIRYFQIADETGSPIAYFYL
HHCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHCCEEEEEECCCCCCEEEEEE
DPYSRPAEKRGGAWMDTCINRAIITENGVTTVRLPVAYLVCNQTPPVDGKPSLMTFYEVE
CCCCCCHHHCCCCHHHHHHCCEEEECCCCEEEEEHEEEEEECCCCCCCCCCCEEHHHHHH
TLFHEFGHGLHHMLTKVNYTGAAGINNVEWDAVELPSQFMENWCYERTTLFSLAKHYQTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETLPEHYYQKLLAARNYMSGSGILRQLHFSSVDLELHSRYRPGGQETAADVRHRVAQKTT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCC
VLPPLPEDAFLCAFGHIFAGGYAAGYYSYKWAEVLSADAFAAFEDAGLEDEAAIKATGRR
CCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHH
YRDTVLALGGSKHPMEVFAAFRGREPSTTSLLKHNGLLPNAA
HHHHHEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]