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The map label for this gene is glpK [H]

Identifier: 16767065

GI number: 16767065

Start: 3980753

End: 3982237

Strand: Reverse

Name: glpK [H]

Synonym: STM3781

Alternate gene names: 16767065

Gene position: 3982237-3980753 (Counterclockwise)

Preceding gene: 16767066

Following gene: 16767064

Centisome position: 81.98

GC content: 49.02

Gene sequence:

>1485_bases
ATGCCTGATTACCACGCAGCGCTTGTCATTGACATTGGCACAACTAACTGCAAAGTCAGCTGTTATTCCTGTCATGACGT
GTCAGTTCTGGAAGTCCGCAAGTTTCCGACGCCAACAATATCGTCGGACAAAGGCGAGGTAGATTTCGATATCGAAGCGC
TGTGGCAGGCACTGCGACTGGTAATGGCTGAACTGGTGGCTTCAGTACCGTTTCCGGTAAAAAATATCAGTATTGCGAGT
TTCGGTGAGTCTGGCGTCTTTGTGGATAAGGAGGGCGTCATTCTTACCCCGATGCTGGCCTGGTATGATCGACGTGGTGA
ATCTTATCTCTCGTCATTAAGCAAGGCAGAGGCTGAAGAACTGTATTCTATAACGGGATTGCCACCTCACAGTAATTACT
CAGCATTTAAAATGAGATGGTTGCTTGATAACTATTCCTTGCATGAAAGAAAAGATATCTGCTGGTTACATGCACCAGAA
GTGTTGTTGTGGAGAATGACAGGTGCGAAAAAGACGGAAATATCCCTGGCCAGTAGAACGTTGTGTCTGGACATTGCTCG
CCGTACCTGGTCTCGTAATGCTGCCGGGATTCTCGGCATACCGTTCGGTGTACTGGCTCCGTTGATAAAGCCAGGTGAAG
TGGCCGGATGGATGACGGCAACGCTTAGAGAGGAATTGGGCTTCTCTCATGAGGTAAAAGTCACCCTCGCTGGACACGAT
CATATGGTCGGTGCCCGCGCATTACAGATGCAACCGGGCGATGTGCTGAATTCTACCGGCACGACAGAGGGTATTTTACT
GCTGAATACACAGCCAACGCTTGATGTGCAGGCTCGCAGGAATAAGCTGGCAAATGGTTGTTACTCCGATGGTGAATTTT
TCACGCTTTTCGCTTCTCTGCCTGTCGGCGGTTATGCGCTTGAATGGGTGAAAAAAACCTTTCGTTTAACTGATAAGGAA
ATAAGCACAGGCCTGGAAAAAGTCATGGAGCAGTACCTCAAACCTTCCTGGTCTGTCGAGCATGTGCCGGTATTTATTCC
TCATTTGCGGGGCTCGGGTTCGCCAAATAAAAATCGGCACACTCGTGGCCTGCTTTTTGGTCTGACGGATTCACTTCCTC
CGGAGTCTCTGCTTGAGAGTGTCTTTATTGGCCTGGCGATGGAGTTTGCACACTGTCACGGGTGCTTTAATATCCCGGCG
GGCAGGACAGTAAAAGTCATTGGCCCTGCGGTGAAAAACCCATACTGGCTCCAGTTGAAGGCTGACATCCTCCAGTGTCC
AATTGAGGCCATTGCTTTTGATGAAACCGTCTCCCTTGGAGCATTGTTGATAGCCTGTCCGAATGTTGTCCCCCCGACTG
TTCCTGTGGCTGAGCGATATTTTCCTGACGCGGTTCGTTCTGCAAAGTTGAAAATATATCAGCAGCAATGGCTGTCATTT
TACCAATTTAAACTGCGGCAAGAAGGGGCGCTTATTGGTGAATAA

Upstream 100 bases:

>100_bases
CTGCTTGAAATATTCAACGGAAATATTATTGCTATCGGGCTGATTCCTGTGCTTGCGCTGATTATTTATGGTGTTTTTCG
CCTGACAAAAGGAACGGTCT

Downstream 100 bases:

>100_bases
CTGTGATAACTCAATAGTTCGATAATTTACTTACACTGCTCACATAAATATCTGGAGTTAATATGCCTTTAGTCAATGGT
AGGATCCTGCTCAATTGTAT

Product: sugar kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDFDIEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWMTATLREELGFSHEVKVTLAGHD
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRNKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGALIGE

Sequences:

>Translated_494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDFDIEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWMTATLREELGFSHEVKVTLAGHD
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRNKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGALIGE
>Mature_493_residues
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDFDIEALWQALRLVMAELVASVPFPVKNISIASF
GESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEV
LLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWMTATLREELGFSHEVKVTLAGHDH
MVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRNKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKEI
STGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAG
RTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSFY
QFKLRQEGALIGE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=384, Percent_Identity=25.5208333333333, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI42794763, Length=387, Percent_Identity=25.0645994832041, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4504007, Length=384, Percent_Identity=25.5208333333333, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI41393575, Length=376, Percent_Identity=23.936170212766, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1789168, Length=458, Percent_Identity=23.7991266375546, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=23.780487804878, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790361, Length=464, Percent_Identity=21.7672413793103, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=371, Percent_Identity=25.0673854447439, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17864214, Length=394, Percent_Identity=25.1269035532995, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24654573, Length=394, Percent_Identity=25.3807106598985, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24655555, Length=466, Percent_Identity=21.4592274678112, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655560, Length=466, Percent_Identity=21.4592274678112, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655570, Length=466, Percent_Identity=21.4592274678112, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655574, Length=466, Percent_Identity=21.4592274678112, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655565, Length=466, Percent_Identity=21.4592274678112, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54766; Mature: 54635

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDFDIEALWQALRL
CCCCEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEECHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWMTATLREELGFSHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRNKLANGCYSDGEFFTLFASL
CCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGALIGE
HHHHHHHCCCCCCC
>Mature Secondary Structure 
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDFDIEALWQALRL
CCCEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEECHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWMTATLREELGFSHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRNKLANGCYSDGEFFTLFASL
CCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGALIGE
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]